Pregnancy following kidney transplantation: Risk for offsprings

Kozłowska-Boszko, B; Korczak, G.; Wierzbicki, Piotr; Lis, Karol; Gaciong, Zbigniew; M, Lao; Sicińska, Justyna; Górski, Andrzej

doi:10.1016/s0041-1345(96)00088-7

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…Other studies with children exposed to immunosuppressive drugs in utero did not report differences in white cell counts or total lymphocytes (8,31). However, it is known that azathioprine may cause Ono et al leukopenia and even myelosuppression (32).…”

Section: Discussionmentioning

confidence: 97%

“…A detailed analysis of the literature shows that mothers from different groups have used varied immunosuppressive schemes (3,(7)(8)(9)31,(34)(35)(36). Currently, three drugs are used-one calcineurin inhibitor, one corticosteroid and one antiproliferative agent, usually azathioprine or mycophenolic acid (37).…”

Section: Discussionmentioning

confidence: 99%

“…Different studies have observed immune recovery in the first month of life (31) or at 3 months (8). However, immunologic alterations have been observed up to 1 year of age among children born to mothers on immunosuppressive drugs (8,42).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Ono

Santos

Viana

et al. 2015

American Journal of Transplantation

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Ono

Santos

Viana

et al. 2015

American Journal of Transplantation

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“…Even if the lymphocytes count is normal, the CD4+/CD8+ ratio of the offspring is usually higher when the mother is immunosuppressed. Koslowska-Boszko et al [37] report a high incidence of newborns exposed to prednisone, AZA or CsA in utero presenting with a diminished proportion of CD4+ (11/13) and CD8+ T cells (7/13) on the 1st day of life. In only 2/6 and 1/5 cases, the levels of CD4+ and CD8+, respectively, were normal on the 30th day, suggesting a slow recovery.…”

Section: Aza 6-mpmentioning

confidence: 99%

“…In only 2/6 and 1/5 cases, the levels of CD4+ and CD8+, respectively, were normal on the 30th day, suggesting a slow recovery. These neonates were clinically asymptomatic in 12/13 cases, but the immunomonitoring of children exposed to AZA is recommended [37]. Other reported adverse effects are decreased thymic shadow, anemia, reduced immunoglobulin levels, infections and septicemia, chromosomal abnormalities that may persist for up to 1 year, as well as sequelae from preterm delivery and IUGR [4,36].…”

Section: Aza 6-mpmentioning

confidence: 99%

In utero Exposure to Immunosuppressive Drugs

Prévot

Martini

Guignard³

2002

Neonatology

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The number of pregnant women receiving immunosuppressants for anti-rejection therapy or autoimmune diseases is increasing. All immunosuppressive drugs cross the placenta, raising questions about the long-term outcome of the children exposed in utero. There is no higher risk of congenital anomalies. However, an increased incidence of prematurity, intrauterine growth retardation (IUGR) and generally low birth weight has been reported, as well as maternal hypertension and preeclampsia. The most frequent neonatal complications are those associated with prematurity and IUGR, as well as adrenal insufficiency with corticosteroids, immunological disturbances with azathioprine and cyclosporine, and hyperkalemia with tacrolimus. The long-term follow-up of infants exposed to immunosuppressants in utero is still limited and experimental studies raise the question whether there could be an increased incidence at adult age of some pathologies including renal insufficiency, hypertension and diabetes.

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Pregnancy outcome post renal transplantation

et al. 2002

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Background:The success in performing organ transplantations and prevention of rejection has resulted not only in a substantial increase in life expectancy, but also improvement in the patients' quality of life. Thus, women who underwent organ transplantation are now reaching puberty and the age of reproduction. This has presented new challenges regarding the teratogenicity and the long-term effect of immunosuppressive medications used by these patients. Previous studies have shown that pregnancies after renal transplantation are associated with an increased risk for both the mother and the fetus. There is, however, very little information available on neonatal and long-term pediatric follow-up of babies born to mothers who have undergone renal transplantation and have been exposed to immunosuppressive medications, compared to controls. We report the experience of our center, the largest in Canada, regarding the prenatal and long-term postnatal outcome of pregnancies after renal transplantation.

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Pregnancy following kidney transplantation: Risk for offsprings

Cited by 15 publications

References 18 publications

Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients

In utero Exposure to Immunosuppressive Drugs

Pregnancy outcome post renal transplantation

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