Pregnancy Following Heart Transplantation: A Single Centre Case Series and Review of the Literature

Boyle, Siobhán; Mew, T.; Lust, Karin; McKenzie, S.; Javorsky, G.; Parsonage, William

doi:10.1016/j.hlc.2020.10.007

Cited by 14 publications

(9 citation statements)

References 27 publications

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“…The first successful delivery of a healthy child from a mother with previous heart transplantation was reported in the late 1980s [12]. There is a paucity of data on pregnant women with prior medical history of HT and limited to observational studies, small cohorts or registry reports [1 ▪▪ ,12,13]. The ISHLT released a comprehensive consensus guideline document on reproductive health after thoracic transplantation in 2022 [11 ▪▪ ].…”

Section: Heart Transplantationmentioning

confidence: 99%

Management of pregnancy in left ventricular assist device and heart transplant recipients: a concise review

Marek-Iannucci

Uber

Rajapreyar

2023

Current Opinion in Cardiology

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Purpose of reviewWomen of reproductive age are increasingly undergoing heart transplantation (HT) or left ventricular assist device (LVAD) implantation for advanced heart failure. This review is intended to give an overview of the current state of the art management of pregnancy in patients with LVAD or HT recipients.Recent findingsHeart transplant recipients are at increased risk for graft rejection, renal dysfunction, preeclampsia and worsening of comorbidities (hypertension and diabetes). Patients with LVAD are at higher risk of thromboembolic events, infections, right ventricular failure and require close surveillance during pregnancy. Preconception counseling must be offered to all women of reproductive age group with HT or LVAD to avoid unplanned pregnancies.SummaryA multidisciplinary approach with close antepartum and postpartum surveillance is recommended.

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Section: Heart Transplantationmentioning

confidence: 99%

Management of pregnancy in left ventricular assist device and heart transplant recipients: a concise review

Marek-Iannucci

Uber

Rajapreyar

2023

Current Opinion in Cardiology

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“…No adverse event was reported in 12 breastfed infants exposed to MMF. 113,114 Breastfeeding is contraindicated, according to the label.…”

Section: Mycophenolate Mofetil (Mmf)mentioning

confidence: 99%

Pregnancy and multiple sclerosis: 2022 recommendations from the French multiple sclerosis society

Vukusic

Ciron²,

Maillart

et al. 2022

Mult Scler

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Objective: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). Background: MS typically affects young women in their childbearing years. Increasing evidence is available to inform questions raised by MS patients and health professionals about pregnancy issues. Methods: The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed PubMed and university databases (January 1975 through June 2021). The RAND/UCLA appropriateness method was developed to synthesise the scientific literature and expert opinions on healthcare topics; it was used to reach a formal agreement. Fifty-six MS experts worked on the full-text review and initial wording of recommendations. A group of 62 multidisciplinary healthcare specialists validated the final proposal of summarised evidence. Results: A strong agreement was reached for all 104 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and postpartum, delivery routes, locoregional analgesia or anaesthesia, prevention of postpartum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses and disease-modifying treatments. Conclusion: The 2022 recommendations of the French MS society should be helpful to harmonise counselling and treatment practice for pregnancy in persons with MS, allowing for better and individualised choices.

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“…No adverse event was reported in 12 breastfed infants exposed to MMF. 33,34 Breastfeeding is contraindicated, according to the label.…”

Section: Mycophenolate Mofetil (Mmf)mentioning

confidence: 99%

Pregnancy and neuromyelitis optica spectrum disorders: 2022 recommendations from the French Multiple Sclerosis Society

et al. 2022

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Background: In 2020, the French Multiple Sclerosis (MS) Society (SFSEP) decided to develop a national evidence-based consensus on pregnancy in MS. As neuromyelitis optica spectrum disorders (NMOSD) shares a series of commonalities with MS, but also some significant differences, specific recommendations had to be developed. Objectives: To establish recommendations on pregnancy in women with NMOSD. Methods: The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed PubMed and universities databases (January 1975 through June 2021). The RAND/UCLA appropriateness method, which was developed to synthesise the scientific literature and expert opinions on health care topics, was used to reach a formal agreement. Fifty-six MS experts worked on the full-text review and initial wording of recommendations. A sub-group of nine NMOSD experts was dedicated to analysing available data on NMOSD. A group of 62 multidisciplinary healthcare specialists validated the final proposal of summarised evidence. Results: A strong agreement was reached for all 66 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and postpartum, delivery routes, loco-regional analgesia or anaesthesia, prevention of postpartum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses, and disease-modifying treatments. Conclusion: Physicians and patients should be aware of the new and specific evidence-based recommendations of the French MS Society for pregnancy in women with NMOSD. They should help harmonise counselling and treatment practise, allowing for better individualised choices.

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Pregnancy Following Heart Transplantation: A Single Centre Case Series and Review of the Literature

Cited by 14 publications

References 27 publications

Management of pregnancy in left ventricular assist device and heart transplant recipients: a concise review

Management of pregnancy in left ventricular assist device and heart transplant recipients: a concise review

Pregnancy and multiple sclerosis: 2022 recommendations from the French multiple sclerosis society

Pregnancy and neuromyelitis optica spectrum disorders: 2022 recommendations from the French Multiple Sclerosis Society

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