Pregnancy favors the expansion of circulating functional follicular helper T Cells

Monteiro, Clarice; Kasahara, Taissa M.; Castro, José Roberto; Sacramento, Priscila M.; Hygino, Joana; Centurião, Newton; Cassano, Tatiane; Lopes, Lana M; Leite, Simone; Silva, Vander Guimarães; Gupta, Sudhir; Bento, Cleonice A.M.

doi:10.1016/j.jri.2017.04.007

Cited by 23 publications

(39 citation statements)

References 44 publications

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“…29,30 This maternal immunomodulation not only avoids maternal fetus rejection but also enhances antibody production by pregnant women following vaccination, which promotes passive immunity via IgG transfer through the placenta and breastfeeding. 32 This phenomenon was directly associated with estrogen levels and anti-HBs IgG titers. 32 This phenomenon was directly associated with estrogen levels and anti-HBs IgG titers.…”

Section: Introductionmentioning

confidence: 96%

“…32 This phenomenon was directly associated with estrogen levels and anti-HBs IgG titers. 32 Nevertheless, the impact of HIV-1 infection on the homeostasis of cT FH cells in pregnant women (PW) has not been evaluated. Therefore, the objective of the present study was to investigate the frequency of different T FH -like cells in HIV-infected PW prior to and following ARV therapy.…”

Section: Introductionmentioning

confidence: 96%

“…31 In this context, a recent study published by our group demonstrated that pregnancy favors an expansion of functional cT FH cells. 32 Nevertheless, the impact of HIV-1 infection on the homeostasis of cT FH cells in pregnant women (PW) has not been evaluated. 32 Nevertheless, the impact of HIV-1 infection on the homeostasis of cT FH cells in pregnant women (PW) has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…This phenomenon can be linked to the ability of IL-10 to reduce both IL-6 production 38 and HIV-1 replication 39. Interestingly, a higher frequency of CXCR3 + CXCR5 + CD4 + T cells able to produce IL-21 and IFN-γ has been observed in healthy HIV-1-negative PW during the third trimester of gestation, as compared with nPW ones 32. Although HIV-1 treatment had increased the frequency of IFN-γ + T FH -like cells in both HIV-1-infected groups of patients, ARV was more efficient in elevating the proportion of IL-21-secreting T FH -like cells in PW.…”

mentioning

confidence: 98%

“…The mean values were compared and the P values presented in the figures and T FH cells 30,32. In (A) representative Dot-Plots and histograms of CXCR5 + CD4 + T-cell subsets in PW infected by HIV-1 before (Naïve) and after ARV therapy.…”

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confidence: 99%

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Pregnancy favors circulating IL‐21–secreting T_FH‐like cell recovery in ARV‐treated HIV‐1–infected women

Kasahara

Monteiro

Hygino

et al. 2019

American J Rep Immunol

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Problem: Pregnancy appears to favor maternal antibody production. In contrast, by damaging follicular helper T cells (T FH ), HIV-1 infection compromises protective humoural immune response. Therefore, we aimed to investigate the frequency of different T FH -like cells in HIV-infected pregnant women (PW) before and after antiretroviral (ARV) therapy. Method of study:Peripheral blood mononuclear cells, CD4 + T and B cells, were obtained from asymptomatic HIV-1-infected non-PW and PW just before and after ARV therapy. In some experiments, healthy HIV-1-negative PW were also tested.The frequency of different T FH -like cell subsets was determined by flow cytometry.The plasma titers of IgG anti-tetanus toxoid (TT), anti-HBsAg, and anti-gp41 were determined by ELISA. The in vitro production of total IgG, IL-21, and hormones (estrogen and progesterone) was quantified also by ELISA. Results:Our results demonstrate that antiretroviral (ARV) therapy was more efficient in elevating the percentage of circulating IL-21-secreting T FH cells in HIV-1-infected pregnant women (PW) than in non-pregnant patients (nPW). Moreover, in co-culture systems, CD4 + T cells from ART-treated PW were more efficient in assisting B cells to produce IgG production. The in vivo anti-HBsAg IgG titers after ARV therapy were also significantly higher in PW, and their levels were directly associated with both IL-21 + T FH frequency and plasma concentration of estrogen. Conclusion:In summary, our results suggest that pregnancy favors the recovery of T FHlike cells after ARV therapy in HIV-1-infected women, which could help these mothers to protect their newborns from infectious diseases by transferring IgG across the placenta. K E Y W O R D Santiretroviral therapy, estrogen, HIV-1, IgG, TFH cells

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 99%

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Pregnancy favors circulating IL‐21–secreting T_FH‐like cell recovery in ARV‐treated HIV‐1–infected women

Kasahara

Monteiro

Hygino

et al. 2019

American J Rep Immunol

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Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating T_FH/B cell axis

et al. 2020

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Circulating TFH (cTFH) cells express CXCR5, PD‐1, and, when activated, ICOS, and release IL‐21. According to the production of IFN‐γ, IL‐4, and IL‐17 and expression of FoxP3, these cells are also classified as cTFH1, cTFH2, cTFH17, and cTFR cells, respectively. This CD4+T‐cell subset is pivotal to efficient humoral immunity, and pregnancy appears to favor IgG production. Here, not only pregnancy amplified the in vivo production of anti‐HBsAg IgG in HBV immunized women, but the frequency of cTFH cells was directly correlated with estradiol levels. In vitro, pregnancy‐related dose of 17‐β‐estradiol (E2) directly increased the percentage of different cTFH subsets. While E2 and progesterone (P4) increased the proportion of differentiated TFH cells derived from naïve CD4+T‐cells, only E2 amplified the release of IL‐21 in those cell cultures. In addition, E2 and P4 increased the proportion of memory B cells and plasma cells, respectively. In SEB‐activated B/TFH cell co‐cultures, E2, in the presence of P4, increased the production of total IgG. Finally, among the hormones, P4 was stronger in upregulating the percentage of IL‐10+TFR cells. Collectively, our findings suggested that E2 and P4 cooperate in the humoral immune response by favoring the expansion of different cTFH and B cell subsets.

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T helper cell pathology and recurrent pregnancy losses; Th1/Th2, Treg/Th17, and other T cell responses

Park

Han

Lee

2022

Immunology of Recurrent Pregnancy Loss and Implantation Failure

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Pregnancy favors the expansion of circulating functional follicular helper T Cells

Cited by 23 publications

References 44 publications

Pregnancy favors circulating IL‐21–secreting T_FH‐like cell recovery in ARV‐treated HIV‐1–infected women

Pregnancy favors circulating IL‐21–secreting T_FH‐like cell recovery in ARV‐treated HIV‐1–infected women

Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating T_FH/B cell axis

T helper cell pathology and recurrent pregnancy losses; Th1/Th2, Treg/Th17, and other T cell responses

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Pregnancy favors the expansion of circulating functional follicular helper T Cells

Cited by 23 publications

References 44 publications

Pregnancy favors circulating IL‐21–secreting TFH‐like cell recovery in ARV‐treated HIV‐1–infected women

Pregnancy favors circulating IL‐21–secreting TFH‐like cell recovery in ARV‐treated HIV‐1–infected women

Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating TFH/B cell axis

T helper cell pathology and recurrent pregnancy losses; Th1/Th2, Treg/Th17, and other T cell responses

Contact Info

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Resources

About

Pregnancy favors circulating IL‐21–secreting T_FH‐like cell recovery in ARV‐treated HIV‐1–infected women

Pregnancy favors circulating IL‐21–secreting T_FH‐like cell recovery in ARV‐treated HIV‐1–infected women

Human pregnancy levels of estrogen and progesterone contribute to humoral immunity by activating T_FH/B cell axis