Pregnancy complications and delivery outcomes of pregnant women with influenza

Ács, Nándor; Bánhidy, Ferenc; Puhó, Erzsébet; Czeizel, Andr̀ew E.

doi:10.1080/14767050500381180

Cited by 41 publications

(9 citation statements)

References 6 publications

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“…The limited numbers of studies that report neonatal outcomes from maternal 2009 H1N1 infection do seem to differ from outcomes reported from investigations during seasonal flu outbreaks. In a study conducted in 1,838 pregnant women with seasonal influenza between 1980 and 1996, the authors found no increase in the prevalence of pregnancy complications when compared to the general obstetrical population 17 . Using patients enrolled in the Tennessee Medicaid program, Hartert et al studied 294 women with seasonal influenza.…”

Section: Discussionmentioning

confidence: 94%

Neonatal characteristics and outcomes of pregnancies complicated by influenza infection during the 2009 pandemic

Mendez‐Figueroa

Raker

Anderson

2011

American Journal of Obstetrics and Gynecology

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Objective To describe the neonatal characteristics and outcomes of infants born during the 2009 H1N1 influenza pandemic. Study Design A prospective cohort of pregnant women with ILI was enrolled between the months of June, 2009 and March, 2010. Neonatal characteristics, complication and outcomes were recorded. Results 45 women were included; birth outcomes were available in 41 cases. 16 women had 2009 H1N1 infection and the remaining 25 that tested negative were included in the ILI group. Live births were similar in both groups. Average gestational age at delivery was over 39 weeks; with similar Apgar scores and cord gas pH values. Birth weights in the 2009 H1N1 group were on average 285 grams lower, 3186 vs. 3471 grams (p = 0.04). Three infants were admitted to the NICU. Conclusions In this cohort, 2009 H1N1 infection during pregnancy was associated with a lower birth weight when compared with ILI in pregnancy.

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Section: Discussionmentioning

confidence: 94%

Neonatal characteristics and outcomes of pregnancies complicated by influenza infection during the 2009 pandemic

Mendez‐Figueroa

Raker

Anderson

2011

American Journal of Obstetrics and Gynecology

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“…In the included trials, the diagnosis of influenza had to be defined either by typical clinical symptoms assessed by experienced physicians, serological tests (a fourfold rise of antibodies titers) or real-time polymerase chain reaction (RT-PCR). Cases with influenza A virus infection were targets of this study, so cases with other types of influenza virus infection were excluded [14-17]. …”

Section: Methodsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Influenza A Virus Infection During Pregnancy Associated with an Increased Risk for Stillbirth and Low Birth Weight

Liu

et al. 2017

Kidney Blood Press Res

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Background/Aims: Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. Methods: Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis. Data of included studies was extracted and analyzed by the RevMan software. Results: Pregnant women with anemia (P=0.004, RR=1.46, 95% CI: 1.13-1.88), obesity (P<0.00001, RR=1.35, 95% CI: 1.25-1.46) and asthma (P<0.00001, RR=1.99, 95% CI: 1.67-2.37) had higher rates of influenza virus infection. Regarding birth outcomes, influenza A virus infection did not affect the likelihood for cesarean section. Mothers with influenza had a higher rate of stillbirth (P=0.04, RR=2.36, 95% CI: 1.05-5.31), and their offspring had low 5-minute APGR Scores (P=0.009, RR=1.39, 95% CI: 1.08-1.79). Furthermore, the rate for birth weight < 2500g (P=0.04, RR=1.71, 95% CI: 1.03-2.84) was increased. Conclusion: Results of this study showed that anemia, asthma and obesity during pregnancy are risk factors influenza A virus infection during pregnancy. Moreover, gestational influenza A infection impairs pregnancy outcomes and increases the risk for low birth weight, a known risk factor for later life disease susceptibility.

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“…Less is known about the effects of maternal influenza infection on the fetus. Maternal infections may increase the risk of pre-eclampsia [ 3 ], a major cause of intrauterine growth restriction and preterm birth (PTB), but there are few studies on influenza and risk of pre-eclampsia [ 4 – 7 ]. High rates of PTB were observed among pregnant women hospitalized with influenza during the 2009 pandemic [ 8 – 10 ], but these studies did not include a comparison group of pregnant women without influenza.…”

Section: Introductionmentioning

confidence: 99%

Risk of pregnancy complications and adverse birth outcomes after maternal A(H1N1)pdm09 influenza: a Norwegian population-based cohort study

et al. 2018

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BackgroundThe effects of maternal influenza infection on the fetus remain unclear. We studied mild influenza and influenza antibodies in relation to birth weight and risks of pre-eclampsia, preterm birth (PTB), and small for gestational age (SGA) birth among the unvaccinated participants in the Norwegian Influenza Pregnancy Cohort.MethodsPregnant women attending a routine ultrasound were recruited from four hospitals in Norway shortly after the 2009 A(H1N1) pandemic. The present study was restricted to unvaccinated participants who were pregnant during the pandemic. Information on the participants was obtained through questionnaires and linkage with national registries. Maternal blood samples were collected at delivery. Women with laboratory-confirmed A(H1N1)pdm09 influenza, a clinical diagnosis of influenza, or self-reported influenza during the pandemic were classified as having had influenza. A(H1N1)pdm09-specific antibodies in serum were detected with the hemagglutination-inhibition assay. Detection of antibodies was considered an indicator of infection during the pandemic in the unvaccinated participants. Odds ratios were estimated with logistic regression. Quantile regression was used to estimate differences in the distribution of birth weight.ResultsAmong the 1258 women included in this study, there were 37 cases of pre-eclampsia, 41 births were PTB, and 103 births were SGA. 226 women (18.0%) had influenza during the pandemic. The majority of cases did not receive medical care, and only a small proportion (1.3%) of the cases were hospitalized. Thus, the cases consisted primarily of women with mild illness. No significant associations between influenza and risk of pre-eclampsia, PTB, or SGA birth were observed. Detection of A(H1N1)pdm09-specific antibodies was associated with a lower 10th percentile of birth weight, β = − 159 g (95% CI − 309, − 9).ConclusionsMild influenza illness during pregnancy was not associated with increased risk of pre-eclampsia, PTB or SGA birth. However, influenza infection during pregnancy may reduce the birth weight of the smallest children.

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Pregnancy complications and delivery outcomes of pregnant women with influenza

Abstract: Maternal influenza during pregnancy does not increase the prevalence of pregnancy complications and unsuccessful delivery outcomes.

Cited by 41 publications

References 6 publications

Neonatal characteristics and outcomes of pregnancies complicated by influenza infection during the 2009 pandemic

Neonatal characteristics and outcomes of pregnancies complicated by influenza infection during the 2009 pandemic

A Systematic Review and Meta-Analysis of Influenza A Virus Infection During Pregnancy Associated with an Increased Risk for Stillbirth and Low Birth Weight

Risk of pregnancy complications and adverse birth outcomes after maternal A(H1N1)pdm09 influenza: a Norwegian population-based cohort study

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