Pregnancy complicated by severe Chlamydia psittaci infection acquired from a goat flock: a case report

Villemonteix, P.; Agius, G.; Ducroz, B; Plocoste, V.; Castets, M; Magnin, G

doi:10.1016/0028-2243(90)90101-6

Cited by 15 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Importantly, the test should also be suitable for use in the diagnosis of human infection resulting from exposure to infected animals. Such infections have repeatedly been reported and are of major concern to pregnant women, in whom they can cause abortion or stillbirth and severe or even fatal illness for the woman (4,6,18,39,41).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serological Diagnosis of Ovine Enzootic Abortion by Enzyme-Linked Immunosorbent Assay with a Recombinant Protein Fragment of the Polymorphic Outer Membrane Protein POMP90 ofChlamydophila abortus

et al. 2002

View full text Add to dashboard Cite

Ovine enzootic abortion (OEA) resulting from infection of sheep and goats with Chlamydophila abortus is of major economic importance worldwide. Over the last 50 years the serological diagnosis of infection has been based mainly on the complement fixation test (CFT), which lacks both sensitivity and specificity because of cross-reactive antibodies to other gram-negative bacteria, including another common chlamydial pathogen of sheep, Chlamydophila pecorum. In the present study, a series of overlapping recombinant antigens representing the polymorphic outer membrane protein POMP90 of C. abortus was assessed by enzyme-linked immunosorbent assay (ELISA) with a panel of 143 serum samples from sheep experimentally infected with C. abortus, from sheep clinically free of OEA, and from specific-pathogen-free lambs experimentally infected with different subtypes of C. pecorum. The results were compared to those obtained by CFT and another recently described test, an indirect ELISA (iELISA) with the recombinant OMP91B (rOMP91B) fragment (rOMP91B iELISA) (D. Longbottom, E. Psarrou, M. Livingstone, and E. Vretou, FEMS Microbiol. Lett. 195:157-161, 2001). The rOMP90-3 and rOMP90-4 ELISAs were identified as being more sensitive and specific than CFT. Assays with both fragments were evaluated further with a panel of 294 field serum samples from flocks with documented histories of abortion, from flocks with no clinical histories of abortion but which had a high proportion of samples seropositive by CFT, and from animals with no histories of abortion but from which various C. pecorum subtypes had been isolated. ELISAs with both POMP90 fragments outperformed CFT with serum samples from C. pecorum-infected animals, producing no false-positive results. However, the ELISA with the rOMP90-4 fragment appeared to be more sensitive than the one with rOMP90-3, as it identified more of the OEA-positive samples. The ELISA with the rOMP90-4 fragment was also able to identify apparently healthy animals that were infected with an enteric strain of C. abortus in flocks that were probably infected with both enteric C. abortus and C. pecorum strains. The identification of animals infected with enteric C. abortus is extremely important in controlling the spread of OEA. Overall, the new rOMP90-4 ELISA was found to be a more sensitive and specific test than CFT for differentiating animals infected with C. abortus from those infected with C. pecorum.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In the United Kingdom, chlamydial abortion accounts for about 50% of all diagnosed abortions, resulting in losses estimated to be in excess of £20 million (US$28 million) each year. C. abortus can also cause abortion in cattle (15,27) and pigs (42) and represents a significant zoonotic risk to pregnant women (6,39).…”

mentioning

confidence: 99%

Serological Diagnosis of Ovine Enzootic Abortion by Enzyme-Linked Immunosorbent Assay with a Recombinant Protein Fragment of the Polymorphic Outer Membrane Protein POMP90 ofChlamydophila abortus

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Prevention and control of chlamydophilosis programs focus on reduction of economic losses due to abortion in small ruminants, as Chlamydophila abortus is considered to be of danger for people associated with small ruminants (e.g., farmers, veterinarians) rather than for the general population. The organism also presents a significant hazard for pregnant women in close contact with infected sheep or goats (Johnson et al, 1985;Berthier et al, 1991;Pospiscill et al, 2002;Villemonteix et al 1990;Walder et al, 2005;Rodolakis, 2014).…”

Section: Chlamydophila Infectionmentioning

confidence: 96%

Zoonotic risks from small ruminants

Ganter

2015

Veterinary Microbiology

View full text Add to dashboard Cite

“…As in small ruminants, C. abortus induces late term abortion in pregnant woman exposed to infected goats or sheep during lambing (Wong et al, 1985;Buxton, 1986;Villemonteix et al, 1990;Jorgensen, 1997;Kampinga et al, 2000;Pospichil et al, 2002;Walder et al, 2005). Sometimes, abortion can be associated with severe complications, e.g., septicaemic shock, acute renal failure, disseminated intravascular coagulation or respiratory distress necessitating mechanical ventilation.…”

Section: Introductionmentioning

confidence: 92%