Pregnancy-Associated Plasma Protein-A: Evaluation of a New Biomarker in Renal Transplant Patients

Coşkun, Abdurrahman; Duran, Sadik; Apaydın, Süheyla; Bulut, İsmet; Sariyar, Muzaffer

doi:10.1016/j.transproceed.2007.08.111

Cited by 17 publications

(11 citation statements)

References 21 publications

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“…2). Also, levels of PAPP‐A have been shown to be elevated in renal transplant patients and correlated with levels of F2‐isoprostanes, markers of in vivo oxidative stress (Coskun et al. , 2007; Lauzurica et al.…”

Section: Papp‐a and Oxidative Stressmentioning

confidence: 99%

PAPP‐A: a new anti‐aging target?

Conover

2010

Aging Cell

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SummaryThis article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.

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Section: Papp‐a and Oxidative Stressmentioning

confidence: 99%

PAPP‐A: a new anti‐aging target?

Conover

2010

Aging Cell

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“…As such, PAPP-A was attractive as a potential means to identify ischaemic stress and increased risk of myocardial cell damage prior to the occurrence of necrosis. It is now recognised that PAPP-A associated with acute coronary syndrome circulates in the free, un-complexed form (fPAPP-A) [17], in contrast to cPAPP-A which predominates in non-acute coronary syndrome populations [13]. …”

Section: Discussionmentioning

confidence: 99%

“…In the HD setting, PAPP-A may be a marker for cumulative exposure to the pro-inflammatory, pro-atherosclerotic uraemic milieu, and this is supported by evidence that PAPP-A levels are high in patients immediately following renal transplant, with serial decline in PAPP-A levels reflective of restoration of renal function and normalisation of biochemical and physiological parameters [17,20]. …”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Free Pregnancy-Associated Plasma Protein-A Independently Predicts Mortality in Haemodialysis Patients but Is Not Associated with Recurrent Haemodialysis-Induced Ischaemic Myocardial Injury

Jefferies¹,

Tertti²,

Wittfooth³

et al. 2015

Nephron

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Background/Aims: Pregnancy-associated plasma protein-A (PAPP-A) is a putative marker of atheroma instability and ischaemic myocardial stress prior to necrosis. Total PAPP-A (tPAPP-A) levels in acute coronary syndromes predict adverse outcomes. However, free PAPP-A (fPAPP-A) predominates in the circulation. Ischaemic haemodialysis (HD)-induced cardiac injury (myocardial stunning) is common and is associated with markers of myocardial necrosis, inflammation, cardiovascular events and mortality. Coronary plaque instability in pathophysiology of HD-induced myocardial stunning has not been studied. We aimed to investigate the relationship of fPAPP-A with stunning and mortality. Methods: 130 prevalent patients from two HD centres (Finland and UK) were studied. Pre-HD free, complexed and total PAPP-A were measured by immunoassay. A subset of 62 patients underwent echocardiography to assess HD-induced myocardial stunning. The mean duration of follow-up was 407 ± 98 days. Results: fPAPP-A was elevated (median: 3.45 mIU/l) and correlated with dialysis vintage (r = 0.391, p < 0.001), cardiac troponin T (cTnT; r = 0.29, p = 0.001) and cardiac troponin I (cTnI; r = 0.22, p = 0.01). PAPP-A was not related to stunning. Dialysis vintage and cTnT independently predicted Ln fPAPP-A (model R = 0.463). fPAPP-A, cTnT and age independently predicted death (Nagelkerke R² = 0.362). Conclusions: fPAPP-A, a novel predictor of HD-related mortality, demonstrates better prognostic power than tPAPP-A. Coronary plaque instability may contribute to sub-lethal myocardial injury, but may not be critical in pathogenesis of HD-induced ischaemic cardiac injury.

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“…During pregnancy, PAPP‐A is produced at a high concentration by the trophoblast, but expression has also been reported in endometrium, testis, kidney, colon, bone, and vascular smooth muscle cells . PAPP‐A is potentially proatherosclerotic, and high levels have been reported in acute coronary syndromes, in asthma, and in renal impairment . In the present study, we evaluated the association between acidosis and serum PAPP‐A levels in hemodialysis patients.…”

Section: Introductionmentioning

confidence: 98%