Pregnancy-associated miRNA-clusters

Morales-Prieto, Diana M.; Ospina‐Prieto, Stephanie; Chaiwangyen, Wittaya; Schoenleben, Michael; Markert, Udo R.

doi:10.1016/j.jri.2012.11.001

Cited by 227 publications

(276 citation statements)

References 83 publications

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“…As a result, although many of the miRNAs found to be differentially expressed in the placenta have different targets, they may be controlled by the same promoters and work in a synergistic manner. 10,108 Three miRNA clusters have recently been assessed as potential biomarkers of placenta-related pregnancy disorders such as pre-term labor, and pre-eclampsia. These clusters include C19MC, miR-371-3 (both located on chromosome 19) and C14 (located on chromosome 14).…”

Section: Microrna Regulation In the Placentamentioning

confidence: 99%

“…These clusters include C19MC, miR-371-3 (both located on chromosome 19) and C14 (located on chromosome 14). 10,108 The C19MC miRNA cluster (the most extensively researched of the three) is expressed in trophoblast and placenta-derived stromal cells. 109 Previously, three miRNAs from the C19MC family, miR517a-3P, miR519a-3P and miR-520c-3P, were found in the choriocarcinoma trophoblast cell lines JEG-3 and BeWo.…”

Section: Microrna Regulation In the Placentamentioning

confidence: 99%

“…10,87,115 The suppressive effects of miR-155 can regulate PTEN in a first trimester human trophoblast cell line (HTR8/SVneo), and can thus aid in the regulation of apoptosis through the AP-1/NF-kB pathway. 115 In a similar study, miR-21 was shown to have a direct regulatory effect on PTEN, since miR-21 overexpression in a third trimester human placental cell line downregulated PTEN mRNA and protein.…”

Section: Microrna Regulation In the Placentamentioning

confidence: 99%

“…Since their discovery, miRNAs have emerged as major bioregulatory molecules of various processes including pregnancy. 6,[9][10][11] Pregnancy is a complex physiological process, and we are just beginning to understand the function of miRNAs during pregnancy. Successful mammalian pregnancy depends upon the establishment and maintenance of an adequate maternalfetal interface, and maternal immune tolerance of the semiallogeneic fetus.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNAs, immune cells and pregnancy

et al. 2014

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MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that are expressed in many cell types, where they regulate the expression of complementary RNAs, thus modulating the stability and translation of mRNAs. miRNAs are predicted to regulate the expression of ,50% of all protein coding genes in mammals. Therefore, they participate in virtually all cellular processes investigated so far. Altered miRNAs expressions are associated with both physiological (pregnancy) and pathological processes (cancer). As the dynamic maternal-fetal interface plays a critical role in the maintenance of successful pregnancy, it is not surprising that the miRNAs that are unique to reproductive tissues are abundantly expressed. Research in this field has demonstrated the presence and dysregulation of a distinct set of pregnancy-associated miRNAs; however, most studies have centered on localizing various miRNAs in reproductive microdomains associated with normal or complicated pregnancies. Although several independent miRNA regulatory mechanisms associated with endometrial receptivity, immune cells, angiogenesis and placental development have been studied, miRNA-mediated regulation of pregnancy remains poorly understood. This review provides a summary of the current data on miRNA regulation as well as functional profiles of miRNAs that are found in the uterus, in immune cells associated with maternal tolerance to the fetus, and those involved in angiogenesis and placental development.

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Section: Microrna Regulation In the Placentamentioning

confidence: 99%

Section: Microrna Regulation In the Placentamentioning

confidence: 99%

Section: Microrna Regulation In the Placentamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MicroRNAs, immune cells and pregnancy

et al. 2014

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“…Le gène codant MiR-9 est même présent dans tous les organismes triploblastiques étudiés à ce jour (protostomiens et deutérostomiens). Les microARNs peuvent aussi être moins conservés ; par exemple il existe trois clusters de ces petites molécules spécifiques du placenta humain sur les chromosome 19 (C19MC et MiR-371) et 14 (C14MC), qui sont apparemment absents chez les rongeurs (Morales-Prieto et al 2013). Dans ce texte, nous évoquerons principalement les petits ARNs (siARN et mimes de miARNs) actuellement considérés comme les vecteurs potentiels les plus prometteurs de thérapies dans le court et moyen terme.…”

Section: Introductionunclassified

ARNs non-codants : potentiel d’utilisation thérapeutique

Vaiman¹

2016

bavf

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Les ARNs non codants constituent une classe d'acides nucléiques de plus en plus étudiée. D'abord pensés comme étant une catégorie anecdotique de produits de la transcription, il apparait clairement, que sous la forme de petites molécules (micro ARNs -ou miARNs-, siARNs et piARNs) ou de molécules beaucoup plus longues (long-non coding RNA ou lncRNAs), ils jouent un rôle crucial dans la régula-tion épigénétique de l'expression des gènes, dans le contexte général de l'interférence à ARN. Des molécules synthétiques mimant leur action peuvent aisément être produites (siARNs ou mimes de miARNs) et vont être capables d'inhiber l'expression des gènes (voire de miARNs naturels). L'intérêt thérapeutique de leur utilisation est donc évident dans quasiment tous les domaines de la médecine. Cette utilisation nécessite tout de même de détruire plusieurs verrous techniques ou technologiques, ce qui est clairement en passe de se produire. Mots-clés : petits ARNs non codants, épigénétique, expression des gènes, cancer. Résumé

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Urinary microRNA profiling in pregnant women identifies placental microRNAs that are candidate biomarkers for monitoring placental health

Inno

Laan

2023

FEBS Letters

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MicroRNAs are among the key modulators of placental transcriptome dynamics. This study aimed at comparative profiling of urinary (sampling at 228-230 gestational days, g.days), serum (217-230 g.days), and placental (279-286 g.days) microRNAs in three healthy pregnant women using miR-Nome sequencing. Placenta showed significant enrichment of microRNAs compared with serum and urine (1174, 341, and 193, respectively; P < 10 À5 ). All sample types shared 153 microRNAs, representing candidate biomarkers for placental health. Urine samples contained eight of 56 transcripts from the placenta-specific chromosome 19 microRNA cluster C19MC and one of 91 transcripts (miR-432-5p) from the chromosome 14 cluster C14MC. These data suggest an active filtering at the maternal-fetal interface in passing through only selected microRNAs. Urine represents a valid source to monitor the signature of placenta-expressed microRNAs that are differentially expressed in pregnancy complications.

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Pregnancy-associated miRNA-clusters

Cited by 227 publications

References 83 publications

MicroRNAs, immune cells and pregnancy

MicroRNAs, immune cells and pregnancy

ARNs non-codants : potentiel d’utilisation thérapeutique

Urinary microRNA profiling in pregnant women identifies placental microRNAs that are candidate biomarkers for monitoring placental health

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