Pregnancy‐Associated Glycoprotein Secretion in North Moroccan Goats

Chentouf, Mouad; Amiri, Bassir; Sulon, Joseph; Beckers, Jean‐François; Kirschvink, Nathalie; Boulanouar, B.; Bister, Jean‐Loup

doi:10.1111/j.1439-0531.2007.00973.x

Cited by 8 publications

(7 citation statements)

References 31 publications

(50 reference statements)

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“…This is consistent with our current results, with the difference that each of the PAGs and P 4 reached their highest average on day 88 after mating, then began to decrease slowly and gradually until the date of birth. On the other hand, the PAG and P 4 levels in our data were different from those reported by González et al (2004) and Chentouf et al (2008). We attribute this to the homologous or heterologous goat breed variants that affect P 4 synthesis, and this re ects the genetic strategy for maintaining a pregnancy under severe conditions (Sousa et al, 1999).…”

Section: Discussioncontrasting

confidence: 89%

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Effect Of Ambient Lead on Progesterone and Pregnancy-Associated Glycoprotein 1 And Their Relationship To Abortion In Zaraibi Goats: A Field Study

Harb,

Mosaad,

El-Nakhla

et al. 2023

Preprint

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This study aimed to investigate the impact of ambient lead (Pb) exposure on progesterone (P4) and pregnancy-associated glycoprotein 1 (PAG1) and their relationship with abortion in Egyptian Zaraibi goats, C. hircus. To achieve this, 40 female goats (does) were mated with highly fertile male goats, resulting in a total of 28 pregnant goats. Eight of them aborted, and each of the 12 pregnant goats gave birth to one kid, whereas the remaining eight gave birth to twins. The current data demonstrated that the levels of blood Pb in aborted goats were significantly higher than those in non-aborted goats at all pregnancy stages, and this was followed by significant decreases in serum PAG1 and P4. Furthermore, there were substantial inverse associations between blood Pb concentration and levels of PAG1 and P4, with markedly negative correlation coefficients of -0.88 and − 0.77, respectively, in aborted goats. The threshold level (cut-off point) of Pb required to cause abortion was ≥ 32.08 µg/dl, but for PAG1 and P4 were respectively ≤ 0.95 ng/ml and ≤ 0.48 ng/ml. Additionally, cut-off levels of ≥12.34 ng/ml and ≥ 31.52 ng/ml for P4 and PAG1, respectively, were needed to deliver twins. In conclusion, pollution-induced increases in Pb bioavailability resulted in dramatic decreases in P4 and PAG1 levels, leading to abortions. PAG1 and P4 levels are also key factors in determining whether Zaraibi goats will give birth to twins.

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Section: Discussioncontrasting

confidence: 89%

“…Moreover, in native North Moroccan goats. Chentouf et al (2008) observed statistical differences between goats carrying one or two foetuses. Vasques et al (1995) proposed the relationship between fetal growth rate and PAGs increase during pregnancy in cows as the important decline in PAG1 was re ected by stopped trophectoderm development.…”

Section: Discussionmentioning

confidence: 85%

Effect Of Ambient Lead on Progesterone and Pregnancy-Associated Glycoprotein 1 And Their Relationship To Abortion In Zaraibi Goats: A Field Study

Harb,

Mosaad,

El-Nakhla

et al. 2023

Preprint

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show abstract

“…(2000) found that in goat that delivered twin foetuses had higher cPAGs concentrations than those that delivered single foetus. Moreover, in native North Moroccan goat, Chentouf et al. (2008) observed statistical differences between goats carrying one or two foetuses.…”

Section: Discussionmentioning

confidence: 91%

Pregnancy‐Associated Glycoprotein and Progesterone Concentrations during Pregnancy Failure in Bedouin Goat from the Southwest of Algeria

Charallah

Amirat

Sulon

et al. 2010

Reprod Domestic Animals

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Thirteen female Bedouin goats living in arid land of Algeria Sahara desert were used in this study. These goats were pregnant but they sustained an abortion because of unidentified causes. None of the goats showed any signs of general disease. Plasma concentrations of caprine pregnancy-associated glycoproteins (cPAGs) and progesterone (P4) were determined during pregnancy using radioimmunoassay. The cPAGs concentration was undetectable (<0.8 ng/ml) throughout the first 2 weeks of gestation. From week 3 after mating, cPAGs concentration was detectable with significant individual variations (p < 0.05) reaching a maximum secretion (436.1 ng/ml). Throughout gestation, cPAGs concentration remained relatively constant but decreased few days before abortion, on an average of 9.2 ± 1.2 days (n = 11), except for two females where the concentrations decreased later (1-2 days before abortion). One or two peaks of cPAGs concentrations (in 4/13 and in 9/13 females, respectively) have been measured few weeks before abortion (77-124 days after mating), when a decline of cPAGs was detected. The P4 concentration increased after mating, and was high from the first week till the end of pregnancy. The P4 concentration (9.1 ± 0.9 ng/ml) decreased rapidly (<0.5 ng/ml) after 4 ± 0.7 days (n = 6) or 9.4 ± 1.6 days (n = 7) before abortion. A positive relationship (p < 0.01) was found between P4 and cPAGs concentrations during gestation. Results indicate that cPAGs and P4 measurements can be used for monitoring gestation and for abortion prediction.

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“…Additionally, the evaluation of PAG plasma concentration in does serve as an indicator for early pregnancy detection (Shahin et al, 2013) and also in ewes (El Amiri et al, 2015). It allowed for accurate prediction of pregnancy starting from 21 days after breeding and beyond (Green et al, 2005), and also to estimate the embryo/fetal count in dairy goats (Chentouf et al, 2008). It can be measured by radioimmunoassay (RIA) (Zoli et al, 1992) and ELISA (Green et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Evaluate the effectiveness of Pregnancy-Associated Glycoprotein and Progesterone in predicting the gestational status in Goats

Younis

Aboud

2023

UTJagr

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The objective of this study was to evaluate the PAG and P4 profiles in pregnant and non-pregnant does using Enzyme Immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA), respectively. Additionally, the study aimed to compare the sensitivity (Se), specificity (Sp), and accuracy (Acc) of pregnancy diagnosis using PAG and P4 detection in serum samples. Twenty does were synchronized using P4 sponge+eCG for 12 days, followed by breeding after estrus. Blood samples were collected at different experimental periods (22, 30, 40, and 60 days post-mating) and analyzed using EIA and ELISA. The lambing and Ultrasonographic examination on day 60 were used as a golden standard for pregnancy evaluation. The results demonstrated that both PAG and P4 mean concentrations significantly increased in pregnant does compared to non-pregnant does in all experimental periods. When comparing the efficiency of each method for pregnancy prediction, the PAG assay method showed a sensitivity (Se) similar to P4 (85%) at day 22 post-mating, but reached 100% at day 30 for PAG and day 40 for P4. Additionally, the accuracy (Acc) of the PAG analysis method was higher than P4 at day 22 (80% vs. 75%) and day 30 (95% vs. 85%), and reached 100% on day 40. In contrast, the Acc of the P4 assay for pregnancy diagnosis was 95% at days 40 and 60. The specificity (Sp) was lower in both methods, but the diagnosis using the PAG assay was better than P4 on all days, reaching its optimal value on day 40, while reach to 83% for P4 assay method on day 40 and 60 PM. The present study concluded that both PAG and P4 analyses were specific and reliable methods for pregnancy determination in does starting from day 22 onward, but the PAG assay was more accurate than the P4 assay.

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Pregnancy‐Associated Glycoprotein Secretion in North Moroccan Goats

Cited by 8 publications

References 31 publications

Effect Of Ambient Lead on Progesterone and Pregnancy-Associated Glycoprotein 1 And Their Relationship To Abortion In Zaraibi Goats: A Field Study

Effect Of Ambient Lead on Progesterone and Pregnancy-Associated Glycoprotein 1 And Their Relationship To Abortion In Zaraibi Goats: A Field Study

Pregnancy‐Associated Glycoprotein and Progesterone Concentrations during Pregnancy Failure in Bedouin Goat from the Southwest of Algeria

Evaluate the effectiveness of Pregnancy-Associated Glycoprotein and Progesterone in predicting the gestational status in Goats

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