Pregnancy and the Kidney

Lam, Chun; Karumanchi, S. Ananth

doi:10.1016/b978-0-12-373870-7.00030-2

Cited by 2 publications

(1 citation statement)

References 388 publications

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“…Together, these data suggest that TXA 2 derived from a source external to the endothelium and related to NETosis impairs the vasodilatory response of Akita mice. While platelets, including platelet-derived microvesicles (61)(62)(63), are the best-known source of TXA 2 , it can also be produced by other cells including endothelial cells (64,65), smooth muscle cells (66), and inflammatory cells (30)(31)(32). In Akita mice, the increase in TXA 2 appeared to be NETosis-dependent and derived from a source external to the endothelium.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

Liu,

Yalavarthi,

Tambralli

et al. 2023

Sci. Adv.

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While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-associated complications, such as dysfunctional wound healing, their potential role in diabetic vascular dysfunction has not been studied. Diabetic Akita mice were crossed with either Elane −/− or Pad4 −/− mice to generate NET-deficient diabetic mice. By 24 weeks of age, Akita aortae showed markedly impaired relaxation in response to acetylcholine, indicative of vascular dysfunction. Both Akita- Elane −/− mice and Akita- Pad4 −/− mice had reduced levels of circulating NETs and improved acetylcholine-mediated aortic relaxation. Compared with wild-type aortae, the thromboxane metabolite TXB 2 was roughly 10-fold higher in both intact and endothelium-denuded aortae of Akita mice. In contrast, Akita- Elane −/− and Akita- Pad4 −/− aortae had TXB 2 levels similar to wild type. In summary, inhibition of NETosis by two independent strategies prevented the development of vascular dysfunction in diabetic Akita mice. Thromboxane was up-regulated in the vessel walls of NETosis-competent diabetic mice, suggesting a role for neutrophils in driving the production of this vasoconstrictive and atherogenic prostanoid.

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Section: Discussionmentioning

confidence: 99%

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

Liu,

Yalavarthi,

Tambralli

et al. 2023

Sci. Adv.

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The risk factor for adverse pregnancy outcomes and its impact on clinical effect in IgA nephropathy: A retrospective observational study

Zhang,

Xie,

Peng

et al. 2024

Nephrology

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AimIgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Pregnant IgAN patients are more susceptible to adverse pregnancy outcomes (APO). However, the risk factor for APO and its effects on the long‐term renal outcome of pregnant IgAN patients remained unclear.MethodsWe performed a retrospective observational study covering 2003–2019 that included 44 female IgAN patients with pregnancy history to investigate the risk factor for APO and its impact on clinical outcome in IgAN. Renal function outcome and proteinuria remission were evaluated in pregnant IgAN women with and without APO.ResultsIn this retrospective and observational study, we found that patients with APO exhibited higher levels of serum creatinine and IgM, and lower haemoglobin levels while other clinical characteristics, pathological characteristics and therapy protocol had no significant difference. We found that anaemia and a higher level of serum IgM were independent risk factors for APO. IgAN pregnant women without APO experienced a higher proportion of proteinuria remission than those with APO, but there is no difference in the renal function outcome.ConclusionPregnant IgAN patients with higher risks, including lower haemoglobin levels and higher IgM levels deserve intensive monitoring, and aggressive therapy to reduce proteinuria should be carried out in pregnant IgAN patients with APO.image

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Pregnancy and the Kidney

Cited by 2 publications

References 388 publications

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

The risk factor for adverse pregnancy outcomes and its impact on clinical effect in IgA nephropathy: A retrospective observational study

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