Pregnancy and Takayasu arteritis: case-based review

Bharuthram, Nirvana; Tikly, Mohammed

doi:10.1007/s00296-019-04499-y

Cited by 4 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study found only six TA patients (6.8%) who developed preeclampsia and one patient eclampsia in striking contrast to the literature report of up to 75.9% in the preeclampsia/eclampsia rate [ 6 , 20 – 22 ]. The low incidence of eclampsia/preeclampsia in our study may be due to the effective management of hypertension and TA disease before and following pregnancy.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Poor obstetric outcomes in women with takayasu arteritis: a retrospective cohort study

Bodakçi,

Cansu,

Korkmaz

2024

Rheumatol Int

View full text Add to dashboard Cite

The objective of this study was to assess the pregnancy outcomes in a cohort of patients who experienced pregnancies before and/or after being diagnosed with Takayasu’s arteritis (TA). The present investigation encompassed a total of 88 pregnancies seen in a cohort of 35 patients who met the criteria outlined by the American College of Rheumatology in 1990 for the classification of Takayasu arteritis (TA). Pregnancies were classified into two categories. 1. Pregnancies that occurred before the diagnosis (pre-d or pre-TA) 2. Pregnancies that happened following a diagnosis (post-d or post-TA). Fifty-nine pregnancies (67.0%) occurred in 21 TA patients before the diagnosis with and a complication rate of 15.2%, and twenty-nine pregnancies (33.0%) occurred in 14 patients concomitant with or after TA diagnosis and complication rate 100%. Although the hypertension rate was higher in the pre-d group than in the post-d group, it was not significant (32.2% vs. 10.3%, p = 0.160). However, preeclampsia (20.6% vs. 0%, p = 0.001), low birth weight (27.5% vs. 1.6%, p = 0.001), and prematurity (24.1% vs. 1.6%, p = 0.035) were observed more frequently in the post-d group compared to the pre-d group. The frequency of abortions and in-utero deaths were similar in both groups (p > 0.05). Patients with hypertension had significantly higher rates of preeclampsia (p = 0.003), preterm birth (p = 0.036), low birth weight (p = 0.250), abortion (p = 0.018), in utero death (p = 0.128), and cesarean section (p = 0.005) than those without hypertension. Renal artery involvement was detected in 15 (42.8%) patients. All patients with renal artery involvement had hypertension, and they had significantly more pregnancy complications than the other group (p = 0.001). TA negatively affects pregnancy outcomes. A good control of arterial hypertension before conception and during pregnancy is critical to improve both maternal and fetal outcomes. In addition, detecting renal artery stenosis before pregnancy is important in reducing possible negative pregnancy outcomes.

show abstract

Section: Discussioncontrasting

confidence: 99%

“…The median age at TA diagnosis was 30 . Age at pregnancy onset, median (IQR) years 30 (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). The number of patients in primigravida was 3(8.5%), and multigravida was 32 (91.5%).…”

Section: Demographic Data and Clinical Characteristicsmentioning

confidence: 99%

Poor obstetric outcomes in women with takayasu arteritis: a retrospective cohort study

Bodakçi,

Cansu,

Korkmaz

2024

Rheumatol Int

View full text Add to dashboard Cite

show abstract

“…The primary vasculitis diagnosed were Takayasu Arteritis ( n = 10) [ 17 , 19 , 36 , 39 , 40 , 43 , 49 , 52 , 54 , 59 ], Eosinophilic granulomatosis with polyangiitis (n = 9) [ 20 , 21 , 24 , 42 , 44 , 46 , 55 – 57 ], Granulomatosis with Polyangiitis ( n = 7) [ 13 , 25 , 32 , 45 , 47 , 51 , 53 ], Periarteritis Nodosa ( n = 5) [ 16 , 27 , 29 , 37 , 58 ], Behcet’s disease ( n = 4) [ 12 , 23 , 35 , 38 ], Henoch-Schönlein purpura ( n = 3) [ 15 , 28 , 31 ], Microscopic polyangiitis and Kawasaki Disease (two cases each) [ 11 , 18 ] and [ 22 , 30 ], Buerger’s disease and Cutaneous leukocytoclastic angiitis (one case each) [ 48 ] and [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the 44 primary vasculitis diagnosed in the post-partum period, the first symptom occurred before delivery in 26 cases (59.1%) [ 11 , 15 , 17 – 20 , 27 , 30 , 32 – 35 , 38 – 40 , 42 , 43 , 45 , 47 , 48 , 52 , 54 , 56 – 58 , 60 ]. Among the 6 vasculitis secondary to Systemic Lupus Erythematosus and cryoglobulinaemia [ 14 , 26 , 34 , 41 , 50 , 60 ], the first symptom of vasculitis occurred before delivery in 2 cases only (33.3%) [ 34 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…It was the sole vasculitis involving large arteries described because, unlike giant cell arteritis, it occurred especially among women of childbearing age. Moreover, Takayasu Arteritis is likely to be overrepresented in this review focusing on vasculitis diagnosed within 6 months post-delivery, because angiographic investigations required to confirm the diagnosis were performed after delivery in all cases [ 17 , 19 , 36 , 39 , 40 , 43 , 49 , 52 , 54 , 59 ]. The risk of intra-uterine growth restriction, the need of close monitoring of Blood Pressure and the anaesthetic management of Takayasu Arteritis during labour have been reviewed elsewhere [ 3 , 61 – 64 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systemic vasculitis diagnosed during the post-partum period: case report and review of the literature

Demotier

Orquevaux

N’Guyen

2023

matern health, neonatol and perinatol

View full text Add to dashboard Cite

Introduction The vasculitis diagnosed specifically in the post-partum period are less well known. We report here such a case followed by a descriptive review of the literature. Case report A 25 year-old French nurse reported abrupt-onset musculoskeletal pain 15 days after delivery of her first infant. Her first pregnancy was uneventful. The physical examination yielded only bilateral conjunctivitis and purpuric eruption of lower limbs, and complementary investigations evidenced pulmonary renal syndrome in connection with the diagnosis of Granulomatosis with Polyangiitis. Methods We screened previous articles in Medline database using keywords (i) “post-partum” or “puerperium” (ii)”peripartum” (iii) “pregnancy” associated with “vasculitis”. Full texts were obtained from case reports or cases series whose title or abstract included keywords of interest (or synonyms). These references were secondarily excluded if the diagnosis of vasculitis was not confirmed or made before or more than 6 months after delivery and if vasculitis occurred only in the new born or affected only the cerebral vasculature or the retina. Results Fifty-six cases of vasculitis diagnosed in the post-partum period were included, 50 (89.3%) were secondary to an immunological process and 44 corresponded to primary vasculitis, 4 were secondary to Systemic Lupus Erythematosus, 1 to cryoglobulinaemia and 1 to cryoglobulinaemia associated with inflammatory bowel disease. The main primary vasculitis diagnosed were Takayasu Arteritis (n = 10), Eosinophilic granulomatosis with polyangiitis (n = 9), Granulomatosis with Polyangiitis (n = 7), Periarteritis Nodosa (n = 5) and Behcet’s disease (n = 4). The first symptom occurred before delivery in 26 (59.1%) and maternal death occurred in 4 (9.1%) out of the 44 primary vasculitis cases. Conclusion The vasculitis diagnosed in the post-partum period were mainly primary vasculitis among patients in whom the diagnosis had not been made during pregnancy. In less than half of cases and as described in ours, there were no reported symptoms before delivery. Therefore, the physicians should pay attention to symptoms and keep a high degree of suspicion for vasculitis before as well as after delivery.

show abstract

Successful pregnancies in a patient with Takayasu arteritis and antiphospholipid syndrome, maintained on infliximab corticosteroid-free regimen: case-based review

Jovicic,

Dragasevic,

Petkovic

et al. 2023

Rheumatol Int

View full text Add to dashboard Cite

Pregnancy and Takayasu arteritis: case-based review

Cited by 4 publications

References 27 publications

Poor obstetric outcomes in women with takayasu arteritis: a retrospective cohort study

Poor obstetric outcomes in women with takayasu arteritis: a retrospective cohort study

Systemic vasculitis diagnosed during the post-partum period: case report and review of the literature

Successful pregnancies in a patient with Takayasu arteritis and antiphospholipid syndrome, maintained on infliximab corticosteroid-free regimen: case-based review

Contact Info

Product

Resources

About