Pregnancy and Renal Disease: Predictors for Fetal and Maternal Outcome

Imbasciati, E; Ponticelli, Claudio

doi:10.1159/000168338

Cited by 62 publications

(28 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is further complexity when a transplant recipient becomes pregnant. With the addition of lupus, a situation is created in which the mother, the fetus, the renal graft and SLE are intertwined (24).…”

Section: Systemic Lupus Erythematosus and Pregnancymentioning

confidence: 99%

“…Pregnancy may have been more difficult to sustain when concomitant SLE disease activity was present, and additional silent spontaneous abortions may have occurred in the SLE group (16,(31)(32)(33). Finally, the SLE patients may have been advised to avoid pregnancy in the presence of poor renal function (18,24).…”

Section: Maternal Factorsmentioning

confidence: 99%

“…As one-third of the SLE group was not taking cyclosporine, this difference in hypertension may be attributable to the increased tendency of cyclosporine over azathioprine to be associated with hypertension (24,37). In the lupus pregnancy literature, the issue of hypertension is confounded by pre-eclampsia and lupus nephritis flares (32,(45)(46)(47)(48).…”

Section: Hypertensionmentioning

confidence: 99%

“…The absence of or well-controlled hypertension and good renal function (creatinine Յ 1.4 mg/dL) are the best predictors of favorable pregnancy outcome and long-term graft survival in renal recipients. Severe hypertension predicts poor outcome for mother and fetus (24,43,49), and aggressive control of hypertension is recommended (37,50,51).…”

Section: Hypertensionmentioning

confidence: 99%

See 3 more Smart Citations

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

View full text Add to dashboard Cite

This study compares pregnancy outcomes in systemic lupus erythematosus (SLE) patients post renal transplant with recipients with other primary diagnoses, utilizing data from the National Transplantation Pregnancy Registry, Philadelphia, PA. Recipients were referred from transplant centers nationwide. A retrospective analysis was performed using data from questionnaires, hospital records and telephone interviews. Outcomes of pregnancies post renal transplant secondary to lupus nephritis (SLE: n Ω 38; 60 pregnancies) were compared with the pregnancy outcomes of renal recipients with other diagnoses (non-SLE: n Ω 247; 374 pregnancies). Drug-treated hypertension during pregnancy was less common in the SLE group than in the non-SLE group (45.0% vs. 62.5%, p Ω 0.015). There were fewer cesarean sections in the SLE group (30.2 vs. 53.2%, p Ω 0.008). There was no primary or gestational diabetes in the SLE group. There were no other statistical differences in maternal conditions or pregnancy outcomes between the SLE and non-SLE groups, or in the incidence of post pregnancy graft loss. Female recipients transplanted for renal failure secondary to lupus nephritis can successfully maintain pregnancy. Outcomes are comparable to renal recipients with other diagnoses. Newborns in both groups were often premature and had low birthweight. Overall childhood health was reported to be good; there were no apparent predominant structural malformations among the children.

show abstract

Section: Systemic Lupus Erythematosus and Pregnancymentioning

confidence: 99%

Section: Maternal Factorsmentioning

confidence: 99%

Section: Hypertensionmentioning

confidence: 99%

Section: Hypertensionmentioning

confidence: 99%

See 2 more Smart Citations

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

McGrory¹,

McCloskey²,

DeHoratius

et al. 2003

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…Uncontrolled hypertension hastens the rate of deterioration of renal function in pregnant women suffering from chronic renal failure [14]. Although prospective data are not available, it is probable that strict control of hypertension during pregnancy would have protective effects on the kidney as has been demonstrated in nonpregnant women [15].…”

Section: Discussionmentioning

confidence: 99%

Successful Pregnancy in a Patient with Polycystic Kidney Disease and Advanced Renal Failure without Prophylactic Dialysis

Hassan

Weissmam

Osman

et al. 2001

Nephron

View full text Add to dashboard Cite

Pregnancies in women suffering from advanced chronic renal failure are frequently associated with deterioration of maternal renal function, premature births and low birth weights. Prophylactic dialysis is sometimes instituted since this intervention ameliorates the uremic milieu and improves maternal status and fetal uterine environment. This report describes a successful pregnancy and delivery in a hypertensive woman with advanced chronic renal failure due to polycystic kidney disease without accelerating the natural deterioration of renal function and without instituting prophylactic dialysis. The infant was delivered at full term with a normal birth weight. Thirty months after delivery, growth and development of the child were normal and the rate of deterioration of maternal renal function, assessed by 1/creatinine, was unaffected by pregnancy. Conservative management and effective control of blood pressure may be sufficient to achieve successful pregnancy outcome when women with advanced chronic renal failure become pregnant.

show abstract

Renal Disease

Davison¹,

Baylis²

2002

Medical Disorders in Obstetric Practice

View full text Add to dashboard Cite

Pregnancy and Renal Disease: Predictors for Fetal and Maternal Outcome

Cited by 62 publications

References 47 publications

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

Pregnancy Outcomes in Female Renal Recipients: A Comparison of Systemic Lupus Erythematosus With Other Diagnoses

Successful Pregnancy in a Patient with Polycystic Kidney Disease and Advanced Renal Failure without Prophylactic Dialysis

Renal Disease

Contact Info

Product

Resources

About