Pregnancy and primary Sjögren’s syndrome: management and outcomes in a multicentre retrospective study of 54 pregnancies

Ballester, Claudia; Grobost, Vincent; Roblot, P.; Pourrât, O.; Pierre, Fabrice H.F.; Laurichesse‐Delmas, H.; Gallot, Denis; Aubard, Y.; Bezanahary, Holly; Fauchais, Anne-Laure

doi:10.3109/03009742.2016.1158312

Cited by 25 publications

(26 citation statements)

References 33 publications

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“…The incidence of preterm delivery was significantly higher in women with pSS than the references in several previous studies. [10,[17][18][19][20] Our study is in accordance with these results, and the risk of preterm birth was also fourfold higher in moderate to late preterm subgroups of women with pSS.…”

Section: Discussionsupporting

confidence: 88%

“…[10]Immunological disturbances in patients with pSS could be responsible for the decrease in the neonatal birthweight through placental insufficiency. [10,19] A previous study confirmed that no significant difference was found regarding way of delivery. [22] However, our study indicated a high rate of cesarean section (cases vs references: 37.5% vs 15.0%), consistent with a previous study.…”

Section: Discussionmentioning

confidence: 88%

“…reported that HCQ may play a role in preventing preterm birth and low birth weight of women with pSS. [19]Furthermore, they are proven to decrease the incidence of congenital heart block in neonates caused by anti-SSA/Ro antibodies, anti-SSB/La antibodies.…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy outcomes with Primary Sjogren's syndrome among Chinese women: a retrospective cohort study

Chen

Tian

et al. 2019

Preprint

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Background Data on pregnancy outcomes in Primary Sjogren's syndrome (pSS) women are scarce, and results have been conﬂicting. The aim of our study is to analyze the adverse pregnancy outcome in patients with pSS. Methods This was a retrospective cohort study conducted at a tertiary medical center located in Chengdu, Sichuan, China, from May 2013 to November 2018. The relevant medical records of all pregnant women were retrospectively reviewed. Logistic regression analyses were performed to compute crude odds ratios (crude OR) with 95% confidence intervals (CI) for maternal and fetal outcomes. Adjusted odds ratios (aOR) were estimated by logistic regression adjusted for confounders. Results Women with pSS had a significantly higher incidence of pre-eclampsia (aOR 11.49, 95% CI 1.65-79.98), PPROM (aOR 5.09, 95% CI 1.14-22.63). Compared to general population, pregnant women with pSS were at increased risks of fetal loss (aOR 15.06, 95%CI 1.19 to 191.11), and a higher risk of fetal growth restriction (aOR 15.69, 95%CI 1.61 to 153.33), preterm birth (aOR 5.52, 95%CI 1.83 to 16.65), a cesarean section (aOR 6.53, 95%CI 3.18 to 13.42) and a neonatal intensive care unit admission (aOR 12.86, 95%CI 1.88 to 87.82) after adjusting for confounding factors. The rate of congenital heart block in the pSS group was 4.7%. Conclusions Pregnant women with pSS were at increased risk of having adverse pregnancy outcomes. Women with pSS require prenatal counseling to explain the risks involved and well control of pSS condition before conception and a close antenatal monitoring should be performed by both rheumatologists and obstetricians.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 88%

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Pregnancy outcomes with Primary Sjogren's syndrome among Chinese women: a retrospective cohort study

Chen

Tian

et al. 2019

Preprint

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“…In women with pSS, fetal and pregnancy outcomes are worse than in controls, with higher rate of spontaneous abortions, low birth weight, higher rates of preterm delivery, [153][154][155][156] and heart block in neonates of women with pSS. [157][158][159]…”

Section: Effect On Pregnancymentioning

confidence: 97%

Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome

Chung

Wilgus

Fishbein

et al. 2019

Semin Respir Crit Care Med

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Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by mononuclear cells (principally lymphocytes) infiltrating exocrine glands (e.g., salivary and lacrimal glands), leading to destruction of exocrine epithelial cells and dryness of mucosal surfaces. Cardinal symptoms are dry eyes (xerophthalmia) and dry mouth (xerostomia). Extraglandular sites are affected in 30 to 40% of cases of SS (particularly neurological, kidneys, skin, and lungs). B cell hyperactivity, autoantibody production, and hypergammaglobulinemia are cardinal features of SS. Primary SS is not associated with other autoimmune diseases. However, SS can complicate diverse autoimmune disorders (particularly systemic lupus erythematosus, rheumatoid arthritis, and scleroderma); this form is termed “secondary SS.” Pulmonary involvement is usually not a dominant feature of SS, but may be severe in some cases. In this review, we discuss specific tracheal, bronchiolar, and pulmonary complications of SS including xerotrachea, bronchiolitis, bronchiectasis, interstitial lung disease, nonspecific interstitial pneumonia, usual interstitial pneumonia, lymphoid interstitial pneumonia, organizing pneumonia, acute fibrinous and organizing pneumonia, pulmonary cysts, pleural effusions, pulmonary amyloidosis, and bronchus- or lung-associated lymphomas.

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“…Těhotenství u žen s PSS má ve většině případů stejný průběh jako u zdravé populace, avšak ženy s PSS, které tvoří autoprotilátky anti-Ro/SS-A, mají zvýšené riziko porodu dítěte s neonatálním SLE [14]. Dále se ukazuje, že ženy s PSS mají dvakrát vyšší riziko potratu oproti zdravé populaci [2].…”

Section: Sjögrenův Syndrom a Těhotenstvíunclassified