Pregnancy and neurodevelopmental outcomes with in-utero antiepileptic agent exposure. A pilot study

Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis

“…Three studies reported the rate of preterm delivery among pregnancies after in utero exposure to lamotrigine [40,44,48]. Rates of preterm delivery were reported to be between 6 and 12.5%, which are similar to the rates reported in the general population [57].…”

“…Four studies [24,45,48,49] assessed the association between lamotrigine use during pregnancy and the risk of miscarriage. Although some methodological concerns were detected in some of these studies, especially regarding the outcome assessment, the rate of miscarriages after in utero exposure to lamotrigine was reported to be between 3.8 and 8.3%.…”

“…Three studies (n = 2320) reported the rate of preterm delivery among pregnancies after in utero exposure to lamotrigine [40,44,48]. Rates of preterm delivery were reported as between 6 and 12.5%.…”

“…While two studies [21,24] failed to demonstrate a dose-response affect, two other studies [33,34] found a correlation between the lamotrigine dose and the risk of major congenital malformations. The association between lamotrigine use during pregnancy and the risk of miscarriage was assessed by four studies (n = 9835) [24,45,48,49]. The data were not meta-analyzed because of differences in the comparison groups and concerns for outcome assessment, since the term miscarriage was not well defined in two of the studies.…”

Antiepileptic drug use during pregnancy: sodium valproate is associated with lower offspring IQ

“…The individual impact of each drug on cognitive outcomes, such as the developmental and IQs varies, with reports showing that IQ is affected in children exposed to sodium valproate compared to phenytoin, carbamazepine and lamotrigine 1. Some research has demonstrated that children exposed to sodium valproate during pregnancy had increased likelihood of difficulty with adaptive functioning and of attention deficit hyperactivity disorder (ADHD) 2.…”