Pregnancy and Lactation Alter Vitamin A Metabolism and Kinetics in Rats under Vitamin A-Adequate Dietary Conditions

Li, Yaqi; Tajima, Ayasa; Mattie, Floyd J.; Green, Michael H.; Ross, A. Catharine

doi:10.3390/nu13082853

Cited by 2 publications

(2 citation statements)

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“…It is likely that pregnancy alters vitamin A metabolism and homeostasis in maternal tissues, however the mechanism(s) driving changes in plasma retinol, at RA, 13 cis RA, 4oxo13 cis RA, and binding protein concentrations are unclear and cannot be elucidated in the current analysis. Recently, a kinetic model of retinol changes was reported based on rodent tracer studies and implicated the mobilization of liver retinoids in late pregnancy [ 17 ]. The liver is a major site for vitamin A metabolism, storage, RBP4 and albumin synthesis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…To maintain adequate circulating concentrations of maternal retinol and support maternal retinoic acid signaling in extrahepatic tissues, hepatic stores of vitamin A can be used as a source for circulating retinol in lieu of adequate intake. However, a lack of adequate whole-body stores leads to deficiency and is detrimental to fetal development and pregnancy outcomes [ 8 , 17 ]. Maternal vitamin A deficiency, which is defined as plasma concentrations < 0.7 μM, is associated with night blindness, maternal anemia, risk for preeclampsia, and preterm delivery [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Plasma Retinoid Concentrations Are Altered in Pregnant Women

et al. 2022

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Vitamin A is vital to maternal–fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women (n = 23) during two stages of pregnancy (25–28 weeks gestation and 28–32 weeks gestation) as compared to ≥3 months postpartum. It was hypothesized that plasma retinol, retinol binding protein 4 (RBP4), transthyretin and albumin concentrations would decline during pregnancy and return to baseline by 3 months postpartum. At 25–28 weeks gestation, plasma retinol (−27%), 4-oxo-13-cis-retinoic acid (−34%), and albumin (−22%) concentrations were significantly lower, and all-trans-retinoic acid (+48%) concentrations were significantly higher compared to ≥3 months postpartum in healthy women. In addition, at 28–32 weeks gestation, plasma retinol (−41%), retinol binding protein 4 (RBP4; −17%), transthyretin (TTR; −21%), albumin (−26%), 13-cis-retinoic acid (−23%) and 4-oxo-13-cis-retinoic acid (−48%) concentrations were significantly lower, whereas plasma all-trans-retinoic acid concentrations (+30%) were significantly higher than ≥3 months postpartum. Collectively, the data demonstrates that in healthy pregnancies, retinol plasma concentrations are lower, but all-trans-retinoic acid concentrations are higher than postpartum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma Retinoid Concentrations Are Altered in Pregnant Women

et al. 2022

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The Use of Datasets for Theoretical Subjects to Validate Vitamin A–Related Methods and Experimental Designs

Green

2022

The Journal of Nutrition

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We review recent work in which model-based compartmental analysis has been applied to data for theoretical human subjects in order to study questions related to vitamin A kinetics and metabolism. Using model simulations in this way, one can validate experimental designs, evaluate or improve vitamin A assessment methods, study the influence of perturbations on assessment methods, and/or advance information related to retinol kinetics. We also provide some information on the rationale for assigning physiologically-appropriate values for specified characteristics [e.g., plasma retinol concentration, vitamin A total body stores (TBS), vitamin A intake] to hypothetical individuals; and in addition, we outline how one might first select an appropriate compartmental model for whole-body vitamin A metabolism and then specify physiologically-reasonable values for the associated retinol kinetic parameters. In the studies discussed here, the Simulation, Analysis and Modeling software was used to simulate responses in key model compartments for hypothetical subjects so that model predictions could be compared to assigned values or projected outcomes. For example, in the case of the retinol isotope dilution (RID) method that is used to assess vitamin A status, application of this approach has provided a way to evaluate the accuracy of TBS predictions under different steady state and non-steady state conditions, thus increasing confidence about the validity of RID results obtained in the field. Although datasets for theoretical subjects have been used to evaluate protocols in pharmacokinetics, to our knowledge, other nutrition researchers have not previously used approaches like those described here. Our results to date indicate that this strategy has the potential to provide useful information related not only to vitamin A but perhaps to other nutrients as well.

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Pregnancy and Lactation Alter Vitamin A Metabolism and Kinetics in Rats under Vitamin A-Adequate Dietary Conditions

Cited by 2 publications

References 38 publications

Plasma Retinoid Concentrations Are Altered in Pregnant Women

Plasma Retinoid Concentrations Are Altered in Pregnant Women

The Use of Datasets for Theoretical Subjects to Validate Vitamin A–Related Methods and Experimental Designs

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