Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

Mazur-Biały, Agnieszka; Kołomańska-Bogucka, Daria; Tim, Sabina; Opławski, Marcin

doi:10.3390/jcm9113749

Cited by 25 publications

(35 citation statements)

References 108 publications

(161 reference statements)

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“…The risk of adverse outcome during pregnancy in women with COVID-19 is estimated to be around 2.4%, and 1.8% for the newborn. 34,35 Published epidemiological data indicate that, although the mortality due to COVID-19 in Italy was initially higher than in China, the prognosis of pregnant women in our country is comparable with that in China. An Italian study including 42 pregnancies in women positive for SARS-CoV-2, documented, out of 7000 deliveries observed between February and April 2020 in Lombardy, two preterm deliveries, seven accesses of pregnant women in the ICU with excellent resolution, and no fetal or neonatal deaths.…”

Section: Management Of Patients With Chronic Itpmentioning

confidence: 50%

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Practical Recommendations for the Management of Patients With Itp During the Covid-19 Pandemic

Rodeghiero

Cantoni

Carli

et al. 2021

Mediterr J Hematol Infect Dis

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The current COVID-19 pandemic requires revisiting our current approach to major blood disorders, including ITP (Immune Thrombocytopenia), stirring up the production of several disease-specific practical guidelines. This report describes an updated version of consensus-based practical guidelines on the management of ITP, adapted to the Italian health system and social context. It highlights the role of the hematologist in offering guidance for choosing differentiated approaches in relation to specific circumstances and is intended to provide them with a useful tool for sharing the decision-making process with their patients. Probably, the greatest risk to avoid for a patient with suspected, ongoing or relapsed ITP - that is not severe enough to place him or her at risk for major bleeding - is to be infected in non-hospital and hospital healthcare settings. This risk must be carefully considered when adapting the diagnostic and therapeutic approach. More in detail, the document first addresses the appropriate management for COVID-19 negative patients with newly diagnosed ITP or who experience a relapse of previous ITP, according to first and second-line lines of treatment s and then the management of COVID-19 positive patients according to their severity, from paucisymptomatic to those requiring admission to Intensive Cure Units (ICU). The pros and cons of the different treatments required to correct platelet count are discussed, as are some specific situations, including chronic ITP, splenectomy, thromboembolic complication and anti COVID-19 vaccination.

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Section: Management Of Patients With Chronic Itpmentioning

confidence: 50%

“…The risk of adverse outcome during pregnancy in women with COVID-19 is estimated to be around 2.4%, and 1.8% for the newborn. 34 , 35 …”

Section: Pregnancymentioning

confidence: 99%

Practical Recommendations for the Management of Patients With Itp During the Covid-19 Pandemic

Rodeghiero

Cantoni

Carli

et al. 2021

Mediterr J Hematol Infect Dis

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“…A significant portion of women underwent childbirth when they were suspected or confirmed of the novel coronavirus disease; COVID-19 infection was reported in 9% to 15% of women giving birth in New York City in the first wave of the pandemic in the US 1 – 3 . Many women were likely to have been asymptomatic 2 .…”

Section: Introductionmentioning

confidence: 99%

COVID-19 positivity associated with traumatic stress response to childbirth and no visitors and infant separation in the hospital

Mayopoulos

Ein‐Dor

et al. 2021

Sci Rep

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As the novel coronavirus (COVID-19) has spread globally, a significant portion of pregnant and delivering women were infected with COVID-19. While emerging studies examined birth outcomes in COVID-19 positive women, knowledge of the psychological experience of childbirth and maternal wellness remains lacking. This matched-control survey-based study included a sample of women recruited during the first wave of the pandemic in the US who gave birth in the previous six months. Women reporting confirmed/suspected COVID-19 (n = 68) during pregnancy or childbirth were matched on background factors with women reporting COVID-19 negativity (n = 2,276). We found nearly 50% of COVID positive women endorsed acute traumatic stress symptoms at a clinical level in response to childbirth. This group was more than twice as likely to endorse acute stress and to have no visitors during maternity hospitalization than COVID negative women; they were also less likely to room-in with newborns. The COVID positive group reported higher levels of pain in delivery, lower newborn weights, and more infant admission to neonatal intensive care units. Our findings suggest COVID-19 affected populations are at increased risk for traumatic childbirth and associated risk for psychiatric morbidity. Attention to delivering women’s wellbeing is warranted during the pandemic.

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“…(12,13,14). However, new data emerged in meta-analyses by Allotey et al, [15] Khali et al, [16] and Mazur-Bialy et al, (17) showing that pregnant women may have an increased risk of developing severe symptoms. Therefore, we can extrapolate that viral loads of SARS-CoV-2 in different body Jakimiuk compartments in the population of pregnant women do not negatively deviate from those in non-pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Absence of SARS-CoV-2 RNA in Peritoneal Fluid During Surgery in Pregnant Women Who Are COVID-19 Positive

Jakimiuk¹,

Januszewski²,

Santor-Zaczynska³

et al. 2021

Journal of Minimally Invasive Gynecology

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Study Objective: COVID-19 infection poses significant risks during surgical interventions. We investigated the intraperitoneal presence of SARS-CoV-2 in COVID-19 positive patients. Design: A prospective group study. Setting: Department of Obstetrics and Gynecology designated for COVID-19 patients, Central Clinical Hospital of the Ministry of Interior, Warsaw Patients: Overall, 65 pregnant women with COVID-19 infection underwent caesarian section. The diagnosis was confirmed either by positive antigen test or by positive RT-PCR assay performed within no more than 13 days prior to the operation. Interventions: On the day of the operation, a nasopharyngeal swab was taken, and peritoneal fluid was collected at the beginning of the operation. Both the nasopharyngeal swab and peritoneal fluid samples were tested for SARS-CoV-2. Measurements and Main Results: A total of 65 pregnant women with COVID-19 infection were enrolled in the study. The SARS-CoV-2 RNA test by nasopharyngeal swab produced positive results in 34 patients. In this group as well as in 31 non-confirmed patients all peritoneal fluid samples tested negative for SARS-CoV-2 RNA. Conclusion: These results suggest a low risk of COVID-19 transmission from the peritoneal cavity at the time of laparoscopy or laparotomy

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Pregnancy and Childbirth in the COVID-19 Era—The Course of Disease and Maternal–Fetal Transmission

Cited by 25 publications

References 108 publications

Practical Recommendations for the Management of Patients With Itp During the Covid-19 Pandemic

Practical Recommendations for the Management of Patients With Itp During the Covid-19 Pandemic

COVID-19 positivity associated with traumatic stress response to childbirth and no visitors and infant separation in the hospital

Absence of SARS-CoV-2 RNA in Peritoneal Fluid During Surgery in Pregnant Women Who Are COVID-19 Positive

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