Pregnancy and birth after intracytoplasmic sperm injection with spermatozoa from a patient with tail stump syndrome

Abstract

Tail stump syndrome, which may be associated with primary ciliary dyskinesia, is also associated with morphological defects of the flagellum resulting in severe asthenozoospermia. Until recently, these morphological anomalies caused definite male infertility. Today, however, new methods such as micromanipulation techniques provide a rational therapy for this patient group. A pregnancy followed by living offspring was achieved following the intracytoplasmic injection of immotile spermatozoa from a patient with tail stump syndrome.

Successful twin birth following blastocyst culture of embryos derived from the immotile ejaculated spermatozoa from a patient with primary ciliary dyskinesia: A case report

“…Successful treatment of PCD with the birth of healthy babies following embryo transfer on day three or earlier has been reported using sub-zonal insemination (SUZI) [4][5][6] and intracytoplasmic sperm injection (ICSI) [7][8][9][10][11][12][13]. The hypo-osmotic swelling (HOS) test [14] was used in conjunction with ICSI of immotile spermatozoa with success in several cases as well [15][16][17].…”

Healthy twin live-birth after ionophore treatment in a case of theophylline-resistant Kartagener syndrome

“…There is indeed evidence that Kartagener patients have sperms showing high level of nonreparable DNA damage [27] and/or aneuploidy, particularly disomies [28]. The latter holds also true for PCD patients with heavily dysmorphic flagella, which would further minimize pregnancy rate in such patients [29,30].…”

Ultrastructural Analysis of Tese and Semen Sperm Tails From Patients Exhibiting Absolute Immotility on the Day of Icsi

“…However, in cases with a total absence of either sperm motility or normal forms following ICSI from the patients with dysplasia of fibrous shealth [5], tail stump syndrome [22], and Kartagener syndrome [14], pregnancies and live births have been reported in the literature, but the success rates are still very low. In our study, besides the absence of motility, the patients' sperm morphology was also impaired.…”

“…High incidence of flagellar pathology was found to be the underlying cause of motility disorders that lead to infertility. Motility alterations have been reported in the literature with a variety of numerical or positional anomalies of the microtubules and=or absence of inner or outer dynein arms of axonem [3,13,22] and peri-axonemal structures involve dense fiber (abnormal position or size), and fibrous sheath of sperm flagellum [6][7][8]20]. Incidences of patients exhibiting totally immotile sperm in their ejaculates on the day of intracytoplasmic sperm injection (ICSI) are extremely low.…”