Pregnancy after treatment with hydroxyurea in a patient with primary thrombocythaemia and a history of recurrent abortion.

Abstract

A 28 year old patient with primary thrombocythaemia, who had had two stillbirths in the third trimester, is reported. She was successfully treated with hydroxyurea and delivered a healthy 61b boy by elective caesarean section.

Hematological malignancy and pregnancy: a single-institution experience of 21 cases

“…Although the risk of thromboembolism and placental infarction in pregnancy is significantly increased in primary thrombocythemia, most pregnancies end successfully (Cinkotai et al. , 1994).…”

Exposure to hydroxyurea during pregnancy: a case series

“…4 Moreover, an increased occurrence of thrombotic events expecially in the coronaric district has been reported in the elderly. 5 This toxicity might in part be mediated by an increased expression of adhesion molecules that facilitate adhesion of cells to the vascular endothelium, therefore promoting localized coagulation. 6 We report two patients with APL, who during induction treatment with ATRA plus idarubicin (AIDA protocol) 3 developed an unusual thrombosis of the right ventriculum.…”

“…No malformation was described among documented first-trimester exposures; neither second-and third-trimester exposures resulted in any fetal anomaly. Some authors [4][5][6][7] conclude that clinical reports in humans show that the potential of fetal adverse effects is not very high and often overestimated.…”

Hydroxycarbamide: a user’s guide for chronic myeloproliferative disorders

“…However, there are no published reports of such effects in humans. Of the 15 identified infants born to women treated with hydroxycarbamide during conception or pregnancy [90][91][92], no malformations were observed. There was one stillbirth by a woman with eclampsia who had received hydroxycarbamide therapy throughout her pregnancy [92].…”