Pregnancy After Donor Nephrectomy

Buszta, C; Steinmuller, Donald; Novick, Andrew C.; Schreiber, Martin J.; Cunningham, Robert; Popowniak, Kathryn L.; Streem, Stevan B.; Steinhilber, Diane; Braun, William E.

doi:10.1097/00007890-198512000-00015

Cited by 50 publications

(19 citation statements)

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“…Two previous small studies of kidney donors suggested no significant differences in maternal or fetal outcomes 18 9.4 (14.4) as compared with the general population (6,7). Neither study, however, compared postdonation and predonation pregnancies in the same woman.…”

Section: Pregnancy In Kidney Donorsmentioning

confidence: 88%

“…Data regarding the impact of reduced glomerular filtration rate (GFR) on preg-nancy in women with a single kidney have primarily come from studies in kidney transplant recipients (4,5). In regard to kidney donors, two small series suggested that pregnancy after kidney donation was not associated with an increased risk of adverse fetal or maternal outcomes (6,7). In contrast, a recent analysis of 326 kidney donors from Norway revealed more than a 2.5-fold increase in the adjusted risk of preeclampsia in post-donation pregnancies (8).…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy Outcomes After Kidney Donation

Ibrahim

Akkina

Leister

et al. 2009

American Journal of Transplantation

142

110

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The outcome of pregnancy in kidney donors has generally been viewed to be favorable. We determined fetal and maternal outcomes in a large cohort of kidney donors. A total of 2102 women have donated a kidney at our institution; 1589 donors responded to our pregnancy surveys; 1085 reported 3213 pregnancies and 504 reported none. Fetal and maternal outcomes in postdonation pregnancies were comparable to published rates in the general population. Postdonation (vs. predonation) pregnancies were associated with a lower likelihood of full-term deliveries (73.7% vs. 84.6%, p = 0.0004) and a higher likelihood of fetal loss (19.2% vs. 11.3%, p < 0.0001). Postdonation pregnancies were also associated with a higher risk of gestational diabetes (2.7% vs. 0.7%, p = 0.0001), gestational hypertension (5.7% vs. 0.6%, p < 0.0001), proteinuria (4.3% vs. 1.1%, p < 0.0001) and preeclampsia (5.5% vs. 0.8%, p < 0.0001). Women who had both pre-and post-donation pregnancies were also more likely to have these adverse maternal outcomes in their postdonation pregnancies. In this large survey of previous living donors in a single center, fetal and maternal outcomes and pregnancy outcomes after kidney donation were similar to those reported in the general population, but inferior to predonation pregnancy outcomes.

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Section: Pregnancy In Kidney Donorsmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Pregnancy Outcomes After Kidney Donation

Ibrahim

Akkina

Leister

et al. 2009

American Journal of Transplantation

142

110

View full text Add to dashboard Cite

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“…These reports did not address the issue of pregnancies after kidney donation. Such reports are scarce, but the data available have not indicated an increased risk of adverse pregnancy outcome after unilateral nephrectomy (14)(15)(16)21).…”

Section: Discussionmentioning

confidence: 99%

“…It may be particularly relevant since it is conceivable that increase of blood pressure and loss of kidney function in donors may predispose for hypertensive pregnancy disorders and other complications. Available reports indicate that previous kidney donation is not detrimental to the course and outcome of future pregnancies (14)(15)(16). However, the reports are few and based on a low number of cases.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy and Birth After Kidney Donation: The Norwegian Experience

Reisæter¹,

Røislien

Henriksen

et al. 2009

American Journal of Transplantation

122

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In the adjusted analysis (GLMM) it was more common in pregnancies after donation, 6/106 (5.7%), than in pregnancies before donation 16/620 (2.6%) (p = 0.026). The occurrence of stillbirths after donation was 3/106 (2.8%), before donation 7/620 (1.1%), in controls (1.1%) (p = 0.17). No differences were observed in the occurrence of adverse pregnancy outcome in kidney donors and in the general population in unadjusted analysis. Our finding of more frequent preeclampsia in pregnancies after kidney donation in the secondary analysis must be interpreted with caution, as the number of events was low.

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“…Not only did this individual go on to become pregnant after the transplant operation, but so did her sister (103). Several small self-reporting surveys of women who became pregnant after donation indicated little cause for concern (104,105). A recent abstract presented at the 2006 meeting of the American Society of Nephrology brought out the possibility that donation may increase the risk for preeclampsia in postdonation pregnancies (106).…”

Section: Risks Of Pregnancy To Female Kidney Donorsmentioning

confidence: 99%

Pregnancy after Kidney Transplantation

McKay

Josephson²

2008

Clinical Journal of the American Society of Nephrology

128

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Reproductive success is a common, expected outcome for male and female recipients of solid-organ transplants. Men can father children, and women can become pregnant and carry the fetus to delivery. There are, however, important maternal and fetal complications that need to be considered to provide optimal care to the mother and her infant. Although pregnancy is common after the transplantation of all solid organs, guidelines for optimal counseling and clinical management are limited. This review discusses information to help the physician counsel the kidney transplant recipient about risks of pregnancy for the mother and the fetus and provides information to help guide treatment of the pregnant transplant recipient.

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Pregnancy After Donor Nephrectomy

Cited by 50 publications

References 0 publications

Pregnancy Outcomes After Kidney Donation

Pregnancy Outcomes After Kidney Donation

Pregnancy and Birth After Kidney Donation: The Norwegian Experience

Pregnancy after Kidney Transplantation

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