Pregnancy adverse outcomes related to pregravid body mass index and gestational weight gain, according to the presence or not of gestational diabetes mellitus: A retrospective observational study

Cosson, E.; Cussac‐Pillegand, C.; Benbara, Amélie; Pharisien, I.; Nguyen, Minh Tuan; Chiheb, S.; Valensi, P.; Carbillon, Lionel

doi:10.1016/j.diabet.2015.06.001

Cited by 53 publications

(46 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A consistent association between LGA and gestational weight gain above the IOM guidelines for women of all pre‐pregnancy weight status has been reported . A recent European study reported that overweight and obese pre‐pregnancy conditions were independently associated with LGA infants, regardless of GDM status, and were only associated with small for gestational age infants in women without GDM . The results of this study confirm such an association in women with GDM.…”

Section: Discussionsupporting

confidence: 89%

Incidence of large for gestational age infants when gestational diabetes mellitus is diagnosed early and late in pregnancy

Boriboonhirunsarn

Kasempipatchai

2015

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

Incidence of large for gestational age infants when gestational diabetes mellitus is diagnosed early and late in pregnancy

Boriboonhirunsarn

Kasempipatchai

2015

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…In addition, obesity results in reduced fertility (22, 26), reduced ovarian reserve (3), and reduced quality/quantity of embryos during in vitro fertilization (IVF) (46). Pregnant obese women have a higher-than-normal risk for preeclampsia (13, 58), gestational diabetes (45, 58), macrosomic births (10, 13, 48) and still births (1, 4, 53). Weight loss prior to pregnancy can lead to improvements in these indices; however, long-term body weight loss is difficult to achieve.…”

Section: Introductionmentioning

confidence: 99%

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

et al. 2018

View full text Add to dashboard Cite

Bariatric surgery is increasingly employed to improve fertility and reduce obesity related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnormalities that may be responsible for fetal demise during pregnancy. VSG dams studied on gestational day (G) 19 had reduced circulating T cell (CD3+ and CD8+) populations compared to lean or obese controls. Further, local interleukin 1 β and interleukin 1 receptor antagonist mRNA were increased in placenta of VSG dams. Placental barrier function was also affected, with increased trans-placental permeability to small molecules, increased matrix metalloproteinase 9 expression, and increased apoptosis in VSG. Furthermore, we identified increased placental mTOR signaling that may contribute to preserving the body weight of the fetuses during gestation. These changes occurred in the absence of a macronutrient deficit or gestational hypertension in the VSG dams. In summary, previous VSG in dams may contribute to fetal demise by affecting maternal immune system activity and compromise placental integrity.

show abstract

“…Both high pregestational BMI and high GWG during pregnancy are risk factors for gestational complications and macrosomia [4]. …”

Section: Introductionmentioning

confidence: 99%

Impact of Pregestational Weight and Weight Gain during Pregnancy on Long-Term Risk for Diseases

2017

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to analyse the impact of maternal BMI at start of pregnancy and maternal weight gain during pregnancy on the risk of various diseases later in life.MethodsIn a population-based cohort from southern Sweden, women with at least one delivery registered in the Swedish Medical Birth Register ten or more years before answering a health questionnaire were identified (n = 13,608). Complete data were found in 3,539 women.ResultsWomen with BMI >25 at start of pregnancy had increased risk of developing obesity (OR 21.9), diabetes (OR 6.4), cardiac disease (OR 2.7), endocrine diseases (OR 2.3), and other morbidity (OR 1.4), compared with women of normal weight. A high weight gain (>15 kg) during pregnancy was associated to later risk of overweight (OR 2.0) and obesity (OR 2.2), but not diabetes, cardiac disease, or endocrine diseases. A positive association was found between low weight gain and the risk of developing psychiatric disorders (OR 1.6).ConclusionsA high BMI at start of pregnancy significantly increased the risk of several diseases later in life. However, a high weight gain during pregnancy was only significant for future overweight and obesity. These findings have implications for both pregestational intervention and post gestational follow up of obese and overweight women.

show abstract

Pregnancy adverse outcomes related to pregravid body mass index and gestational weight gain, according to the presence or not of gestational diabetes mellitus: A retrospective observational study

Cited by 53 publications

References 39 publications

Incidence of large for gestational age infants when gestational diabetes mellitus is diagnosed early and late in pregnancy

Incidence of large for gestational age infants when gestational diabetes mellitus is diagnosed early and late in pregnancy

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Impact of Pregestational Weight and Weight Gain during Pregnancy on Long-Term Risk for Diseases

Contact Info

Product

Resources

About