Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome

Amor, David J.; Xu, Jian; Halliday, Jane; Francis, Ivan; Healy, David; Breheny, Sue; Baker, H. W. G.; Jaques, Alice M.

doi:10.1093/humrep/dep046

Cited by 100 publications

(137 citation statements)

References 44 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…46 It is clear that, in the presence of IVF and ICSI, there is an increased risk of the ones caused primarily by epigenetic errors rather than chromosomal problems, such as the case with Beckwith-Weideman syndrome. 47,48 The risk, albeit small, is important because it demonstrates the possibility of other, as yet unidentified, adverse outcomes due to epigenetic errors.…”

Section: Overall Defectsmentioning

confidence: 99%

Outcomes for offspring of men having ICSI for male factor infertility

Halliday¹

2011

Asian J Androl

View full text Add to dashboard Cite

Since the introduction of intracytoplasmic sperm injection (ICSI) using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with poor semen quality, there have been concerns that this might have adverse effects on the offspring compared to conventional in vitro fertilisation (IVF) and natural conceptions. ICSI is done for reasons other than male factor infertility, and on the whole has not been shown to have any more negative effects than those seen with IVF. There have however, been very few studies of ICSI with a focus on, or large enough numbers to examine, the specific outcomes associated with male factor infertility. From the limited information available in relation to the source of the sperm and aetiology of infertility in the presence of ICSI, there appears to be no increased risk of congenital malformations. There is, however, a small increase in both de novo and inherited chromosome abnormalities. In terms of growth and neurodevelopment, there are very few studies, and so far, no adverse outcomes have been found in young children whose fathers have a sperm defect. The origin of the sperm used in ICSI does not have a major influence on the early life outcomes for the offspring, but transgenerational and epigenetic effects remain unknown. When the male factor infertility is known or thought to be due to a Y-chromosome deletion, this information should be given to the young male offspring at a time that will ensure his own reproductive health and plans are optimized.

show abstract

Section: Overall Defectsmentioning

confidence: 99%

Outcomes for offspring of men having ICSI for male factor infertility

Halliday¹

2011

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…The possible association between congenital, malformative and chromosomal defects, and assisted reproduction treatments continues to be a controversial issue in the literature [4,5]. Our study shows that there are no significant differences in multiples of the median (biochemical and ultrasound variables) or in the rate of pathological screening, which need to be confirmed by invasive techniques.…”

Section: Discussionmentioning

confidence: 56%

Natural Pregnancy vs. After Assisted Reproduction treatment Pregnancy, is there a Difference in the Results of the First Quarter Prenatal Screen?

Ruiz¹,

Pacho²,

Rodríguez³

2017

Reprod Syst Sex Disord

View full text Add to dashboard Cite

“…However, it has been shown previously that healthy pregnancies following assisted reproduction have reduced PAPP-A levels in the first trimester compared to naturally conceived pregnancies (Amor et al, 2009). This biomarker is therefore giving information not apparent by other means and may be revealing some impairment of early implantation with some forms of assisted reproduction.…”

Section: Discussionmentioning

confidence: 94%

“…This biomarker is therefore giving information not apparent by other means and may be revealing some impairment of early implantation with some forms of assisted reproduction. Unfortunately, the lower levels found can also increase the risk of receiving a "false-positive" result at the routine first trimester screen and having an unnecessary chorionic villus biopsy or amniocentesis (Amor et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Serum concentrations of the biomarkers CA125, CA15-3, PSA and PAPP-A in early pregnancy

Stemp

Roberts

McClements³

et al. 2016

Journal of Reproductive Biotechnology and Fertility

View full text Add to dashboard Cite

Blood samples were collected serially from 14 women with healthy pregnancies, beginning in gestational week 4 at the time of a positive pregnancy test through to the identification of a foetal heart by ultrasound. Six biomarkers were measured in the serum retrospectively including two reproductive hormones (progesterone and human chorionic gonadotrophin (hCG)) and four additional biomarkers (prostate-specific antigen (PSA), cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125) and pregnancy-associated plasma protein A (PAPP-A)) measured on a Siemens Centaur XP and a Roche Cobas e411 automated analysers, respectively. The progesterone and hCG results were unremarkable following established patterns, but distinctive patterns of change were seen in the other four biomarkers during this period of early pregnancy. PAPP-A and PSA levels rose steadily as the pregnancies progressed, while CA125 levels rose until week 5.5 and then returned to baseline values. CA15-3 serum concentrations were observed to drop as the pregnancies progressed. These biomarker results suggest further investigation is warranted to allow a non-invasive correlation of the biomarkers with the various stages of embryogenesis, implantation and placentation.

show abstract

Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome

Abstract: ART pregnancies have reduced FTS PAPP-A levels leading to an increased likelihood of receiving a false-positive result and having a CVS/amniocentesis. Lower PAPP-A may reflect impairment of early implantation with some forms of ART.

Cited by 100 publications

References 44 publications

Outcomes for offspring of men having ICSI for male factor infertility

Outcomes for offspring of men having ICSI for male factor infertility

Natural Pregnancy vs. After Assisted Reproduction treatment Pregnancy, is there a Difference in the Results of the First Quarter Prenatal Screen?

Serum concentrations of the biomarkers CA125, CA15-3, PSA and PAPP-A in early pregnancy

Contact Info

Product

Resources

About