Pregabalin Reduces Pain in Patients With Chronic Pancreatitis in a Randomized, Controlled Trial

Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs

“…The mechanism of action is not fully known, but part of the therapeutic action on neuropathic pain is thought to involve voltagegated calcium ion channels (Field et al, 2006;. In patients with chronic pancreatitis, which is also thought to be a neuropathic pain disorder , the experimental measure translated into a clinical efficacy, confirmed by traditional questionnaire endpoints (Olesen et al, 2011a).…”

A wide variation in diagnostic and therapeutic strategies in chronic pancreatitis: A Dutch national survey

“…Few use pregabalin, as well as 2 of the 7 experts. The use of pregabalin is supported by the positive outcome of a recent randomized clinical trial, where it relieved chronic pancreatitis pain after 3 weeks of treatment [18].…”

A Paradigm-Shift in Pain Medicine

“…However, the infusion duration was too short to achieve significant decreases in clinical pain experience, illustrating the urgent need for further research in this field involving longer-term treatment approaches. The promise of pursuing such approaches targeting altered pain processing in severe chronic pain syndromes such as chronic pancreatitis is supported by a recent companion publication from our group, demonstrating the analgesic efficacy of another central antihyperalgesic agent, pregabalin, in relieving the pain of chronic pancreatitis 296 . Taken together, these results further underline the usefulness of QST in the management of chronic pain, not only in achieving a choice of pharmacological agent based on effects on pain processing, but also by providing a means of monitoring treatment effect and response.…”