Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial

Sanchis‐Mora, Sandra; Chang, Yu‐Mei; Abeyesinghe, Siobhan; Fisher, AJ; Upton, Neil; Volk, Holger A.; Pelligand, Ludovic

doi:10.1016/j.tvjl.2019.06.006

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…With the highest dose 7.5 mg/kg, some mild signs of sedation were seen in few cats. Similar signs of tiredness and incoordination have been reported as adverse events in clinical use in cats (Lamminen, Korpivaara, Aspegrén, Palestrini, Overall, unpublished data), dogs (Sanchis‐Mora et al, 2019; Thoefner et al, 2020) and humans (Zaccara et al, 2011). A corresponding adverse event profile has been reported also with gabapentin in cats (Van Haafen et al, 2017).…”

Section: Discussionsupporting

confidence: 63%

Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats

Lamminen

Doedée

Hyttilä-Hopponen

et al. 2022

Vet Pharm & Therapeutics

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The study was designed to determine the pharmacokinetic profile and bioavailability of a novel pregabalin 50 mg/ml oral solution formulation (Bonqat ® , Orion Corporation Orion Pharma) in 6 healthy laboratory cats. The cats received pregabalin as single oral doses of 2.5, 5, and 7.5 mg/kg, dose 5 mg/kg on two consecutive days, and a single intravenous dose of 2.5 mg/kg. The washout period between each administration was four weeks. The cats were monitored for clinical signs and level of sedation, and blood samples were taken before pregabalin dosing and at pre-defined time points up to 168 h after dosing. Plasma concentrations of pregabalin were determined using a validated liquid chromatography-tandem mass spectrometry method. The mean maximum plasma concentration of 10.1 μg/ml was reached between 0.5 and 1 h after oral administration of the clinical dose 5 mg/kg. The mean half-life after oral administration of dose 5 mg/kg was 14.7 h and the mean systemic bioavailability was 94%.Pregabalin showed linear pharmacokinetics from 2.5 to 7.5 mg/kg. Exposures after a single dose and re-dosing of 5 mg/kg at 24 h were comparable. Pregabalin was well tolerated with mild sedation and mildly uncoordinated movements observed in few cats at dose 7.5 mg/kg. As a conclusion, study results show rapid absorption, linear pharmacokinetics, and high oral bioavailability of pregabalin without safety concerns after administration of oral solution in cats.

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Section: Discussionsupporting

confidence: 63%

Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats

Lamminen

Doedée

Hyttilä-Hopponen

et al. 2022

Vet Pharm & Therapeutics

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“…The thermal threshold has been used in previous studies to get a more objective measurement of the analgesic effect [ 24 , 25 ]. In dogs, TT has been reliably measured [ 26 ] to evaluate pain in different conditions [ 27 , 28 , 29 ] and to evaluate the efficacy of analgesics [ 30 ]. Thermal threshold testing has been used in human anaesthesia to assess the effect of loco-regional anaesthesia techniques and the differences among several drugs [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Quadratus Lumborum Block as Part of an Opioid-Free Anaesthesia for Canine Ovariohysterectomy

Viscasillas

Sanchis‐Mora

Burillo

et al. 2021

Animals

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Quadratus lumborum block (QLB) is used to provide analgesia for abdominal surgery in humans. The aim of this study was to assess an anaesthetic protocol involving the QLB for canine ovariohysterectomy. Ten dogs were included. Anaesthetic protocol consisted of premedication with IM medetomidine (20 μg kg−1) and SC meloxicam (0.1 mg kg−1), induction with propofol to effect, and maintenance with sevoflurane in oxygen/medical air. QLB was performed injecting 0.4 mL kg−1 of 0.25% bupivacaine/iohexol per side. Computed Tomography (CT) was performed before and after surgery. Fentanyl was administered as rescue analgesia during surgery. The Short Form of The Glasgow Composite Pain Scale and thermal threshold (TT) at the level of the elbow, T10, T13 and L3 were assessed before premedication and every hour postoperatively. Methadone was given as rescue analgesia postoperatively when pain score was >3. A Yuen’s test on trimmed means for dependent samples was used to analyse the data (p < 0.05). CT images showed spreading of the contrast/block for a median (range) of 3 (2–5) vertebrae, without differences between preoperative and postoperative images. One dog needed rescue analgesia during surgery. Pain score was less than 4/24 in all the animals during the first 4 h after surgery. TT showed a significant increased signal in all the areas tested, apart from the humerus, 30 min after surgery. The QLB may provide additional analgesia for canine ovariohysterectomy. Further studies are needed to assess the specific contribution of the QLB in abdominal analgesia.

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“…For the short-term studies, quality of life was improved following prescription of topiramate and gabapentin, but not after prescription of carprofen alone (Plessas and others 2015). Prescription of pregabalin improved owner-reported pain scores, mechanical hyperalgesia, cold hyperalgesia, cold allodynia and was efficacious for treatment of neuropathic pain (Sanchis-Mora and others 2019) and SM-associated phantom scratching (Thoefner and others 2020). For the long-term outcome study, 75 per cent of medically managed dogs had an acceptable quality of life at the end of the follow-up period; the most common medication prescribed was gabapentin or pregabalin (Plessas and others 2012).…”

Section: Medical Managementmentioning

confidence: 99%

“…Medical management of SM is based mostly on anecdotal reports and typically relies on adjuvant analgesics and other unlicensed medication (Fig 5) (Table 4). There have been three short‐term (14 to 25 day) clinical trials assessing carprofen, gabapentin and topiramate (Plessas and others 2015) and pregabalin (Sanchis‐Mora and others 2019, Thoefner and others 2020), in addition to one long‐term (39 [±14.3] months) outcome study (Plessas and others 2012). For the short‐term studies, quality of life was improved following prescription of topiramate and gabapentin, but not after prescription of carprofen alone (Plessas and others 2015).…”

Section: Medical Managementmentioning

confidence: 99%

New considerations about Chiari‐like malformation, syringomyelia and their management

Rusbridge¹

2020

In Practice

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Background: Chiari-like malformation (CM) is a developmental condition, characterised by a conformational change and overcrowding of the brain and cranial cervical spinal cord. CM-associated pain (CM-P) and syringomyelia are increasingly being diagnosed, due to the rising popularity of predisposed brachycephalic breeds and the availability of MRI in veterinary practices.Aim of the article: This article aims to update the veterinary profession on these conditions, and provides a guide to diagnosis and treatment of clinically relevant disease.

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Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial

Cited by 15 publications

References 25 publications

Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats

Pharmacokinetics of single and repeated oral doses of pregabalin oral solution formulation in cats

Evaluation of Quadratus Lumborum Block as Part of an Opioid-Free Anaesthesia for Canine Ovariohysterectomy

New considerations about Chiari‐like malformation, syringomyelia and their management

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