Pregabalin Add‐on Treatment: A Randomized, Double‐blind, Placebo‐controlled, Dose–Response Study in Adults with Partial Seizures

Arroyo, Santiago; Anhut, Henning; Kugler, Alan R.; Lee, Caroline M.; Knapp, Lloyd; Garofalo, Elizabeth; Messmer, Silke

doi:10.1111/j.0013-9580.2004.31203.x

Cited by 246 publications

(209 citation statements)

References 18 publications

(18 reference statements)

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“…From clinical studies, the superiority in its linear and predictable absorption over that of GBP leads to a more differential efficacy and adverse-effects profile between different concentrations (40). Whether its dose-related adverse effects, such as somnolence, dizziness, ataxia, and weight gain, are related to the increase in the activity of K ATP channels remains to be further clarified.…”

Section: Discussionmentioning

confidence: 99%

The Opening Effect of Pregabalin on ATP‐Sensitive Potassium Channels in Differentiated Hippocampal Neuron–derived H19‐7 Cells

Huang

2006

Epilepsia

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Summary:Purpose: Adenosine triphosphate (ATP)-sensitive K + (K ATP ) channels can couple an intracellular metabolic state to an electrical activity, which is important in the control of neuronal excitability and seizure propagation. We investigated whether the newer antiepileptic drug, pregabalin (PGB), could exert effects on K ATP channels in differentiated hippocampal neuron-derived H19-7 cells.Methods: The inside-out configuration of the patch-clamp technique was used to investigate K ATP channel activities in H19-7 cells in the presence of PGB. Effects of various compounds known to alter K ATP channel activities were compared.Results: The activity of K ATP channels in these cells was characterized. The single-channel conductance from a linear currentvoltage relation was 78 ± 2 pS (n = 8) with a reversal potential of 63 ± 2 mV (n = 8), similar to that of K ATP channels reported in pancreatic β cells. 2,4-Dinitrophenol activated channel activity, but the further addition of glucose (20 mM) or glibenclamide (30 μM) could offset these increments. PGB significantly opened these K ATP channel activities in a concentration-dependent fashion with a median effective concentration (EC 50 ) value of 18 μM. A significant increase was noted in the mean open lifetime of K ATP channels in the presence of PGB (1.71 ± 0.04 to 5.62 ± 0.04 ms).Conclusions: This study suggests that in differentiated hippocampal neuron-derived H19-7 cells, the opening effect on K ATP channels could be one of the underlying mechanisms of PGB in the reduction of neuronal excitability.

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Section: Discussionmentioning

confidence: 99%

The Opening Effect of Pregabalin on ATP‐Sensitive Potassium Channels in Differentiated Hippocampal Neuron–derived H19‐7 Cells

Huang

2006

Epilepsia

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“…Seizure freedom: Three trials (Arroyo 2004;Beydoun 2005;French 2003) gave data for the proportion of patients free of seizures for the last eight weeks of the treatment phase, while a fourth trial (Elger 2005) …”

Section: Secondary Outcome Measuresmentioning

confidence: 99%

Pregabalin add-on for drug-resistant partial epilepsy

Lozsadi¹,

Bate²,

Hutton³

et al. 2006

Cochrane Database of Systematic Reviews

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“…39 One of the most important class of drugs used to treat pain is opioids but their use is limited due to side effects such as sedation, dizziness, miosis, respiratory depression, nausea and vomiting. 40 In this study, the incidence of postoperative nausea was significantly lower with the use of pregabalin (p<0.01). This might be related to the decreased use of opioids after surgery and the consequent decrease in opioid-related adverse effects.…”

Section: Discussionmentioning

confidence: 47%

Comparison of Pre-Emptive Pregabalin with Placebo and Diclofenac Combination for Postoperative Analgesia and Cognitive Functions After Laparoscopic Cholecystectomy

Akarsu¹,

Tür²,

Bolat³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : This study was conducted to evaluate the efficacy of pre-emptive pregabalin compared with plasebo and diclofenac combination for attenuating postoperative pain, analgesic consumption and cognitive function after laparoscopic cholecystectomy. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Sixty adults with ASA physical status I-III of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, single-blind study. Subjects were divided into two groups being 30 pat.ents in each to receive either a matching placebo or pregabalin 300 mg, administered orally 1 h before surgery. Intramuscular 75 mg diclofenac sodium was given to placebo patients 15-20 minutes before the estimated finishing time of surgery for pain relief after surgery. In the first 15 minutes after extubation, Aldrete Score and Ramsay Sedation Scale were evaluated. Mini mental test (MMT) was performed 1 hour and 6 hours after extubation. Postoperative pain was assessed by visual analogue scale (VAS). Time to first analgesic requirement, total analgesic dose and side effects were recorded. R Re es su ul lt ts s: : The difference between preoperative 1 st h and 6 th h MMT values was not statistically significant between the two groups. VAS scores were significantly higher in Group C compared to Group P (p <0.01). In Group P, the time to first analgesic rescue dose was significantly longer than in Group C (p<0.01). Total analgesic doses were significantly lower than in Group C patients (p<0.01). Sedation was significantly higher in Group P (p<0.05). C Co on nc cl lu us si io on n: : We conclude that administration of 300 mg of pregabalin 1 hour before surgery lengthens recovery time minimally, prolongs first analgesic requirement time, reduces total analgesic consumption and does not impair cognitive functions.K Ke ey y W Wo or rd ds s: : Cholecystectomy, laparoscopic; anesthesia recovery period; pain; delirium, dementia, amnestic, cognitive disorders Ö ÖZ ZE ET T A Am ma aç ç: : Preemptif pregabalinin plasebo ve diklofenak kombinasyonu ile karşılaştırıldığı laparoskopik kolesistektomi operasyonlarında, postoperatif ağrı, analjezik tüketimi ve bilişsel işlevler üzerindeki etkinliğinin değerlendirilmesi planlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Elektif laparoskopik kolesistektomi uygulanacak ASA I-III sınıfı 60 yetişkin olgu prospektif, randomize, plasebo kontrollü, tek kör çalışma kapsamına alındı. Olgular 30'ar kişilik iki gruba ayrıldı, cerrahiden bir saat önce oral olarak ya bir plasebo (Grup C) veya pregabalin (Grup P) 300 mg verildi. Plasebo alan hastalara tahmini ameliyat bitiminden 15-20 dakika önce intramüsküler 75 mg diklofenak sodyum verildi. Operasyon bitiminde, ekstübasyon saati, göz açma, komutlara yanıt verme ve oryantasyon zamanı kaydedildi. Ekstübasyondan sonra hastalar Aldrete ve Ramsey Sedasyon Skoru ile değerlendirildi. Ekstübasyondan 1 ve 6 saat sonra mini mental test (MMT) uygula...

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Pregabalin Add‐on Treatment: A Randomized, Double‐blind, Placebo‐controlled, Dose–Response Study in Adults with Partial Seizures

Abstract: PGB, 150 mg/day and 600 mg/day, is highly effective and well-tolerated add-on therapy in patients with partial seizures.

Cited by 246 publications

References 18 publications

The Opening Effect of Pregabalin on ATP‐Sensitive Potassium Channels in Differentiated Hippocampal Neuron–derived H19‐7 Cells

The Opening Effect of Pregabalin on ATP‐Sensitive Potassium Channels in Differentiated Hippocampal Neuron–derived H19‐7 Cells

Pregabalin add-on for drug-resistant partial epilepsy

Comparison of Pre-Emptive Pregabalin with Placebo and Diclofenac Combination for Postoperative Analgesia and Cognitive Functions After Laparoscopic Cholecystectomy

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