“…The corpus callosum is a major WM throughfare connecting the hemispheres of the brain. DTI has typically shown decreased FA in various parts of the CC with chronic pain, which varied by study ( Buckalew et al, 2010 , Geha et al, 2008 , Im et al, 2021 , Kim et al, 2014 , Li et al, 2021b , Moayedi et al, 2012 ); in migraine, by contrast, multiple studies found lower FA in all regions of CC ( Li et al, 2011 , Yu et al, 2013 ). Some of these FA changes have been correlated with clinical measures: decreased FA in the CC body of fibromyalgia patients ( Kim et al, 2014 ) and the genu of trigeminal neuralgia patients ( Li et al, 2021b ) were both negatively associated with pain intensity, mirroring our results ( Fig.…”