Prefrontal transcranial direct current stimulation (tDCS) as treatment for major depression: study design and methodology of a multicenter triple blind randomized placebo controlled trial (DepressionDC)

Padberg, Frank; Kumpf, Ulrike; Mansmann, Ulrich; Palm, Ulrich; Plewnia, Christian; Langguth, Berthold; Zwanzger, Peter; Fallgatter, Andreas J.; Nolden, Jana; Burger, Max; Keeser, Daniel; Rupprecht, Rainer; Falkai, Peter; Hasan, Alkomiet; Egert, Silvia; Bajbouj, Malek

doi:10.1007/s00406-017-0769-y

Cited by 45 publications

(42 citation statements)

References 60 publications

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“…Electrodes were located over the right (cathode) and left dlPFC (anode) by standardized neuronavigation before each PET-scan. The location was chosen since it is the montage, which is used in antidepressant treatment trials (Brunoni et al 2017;Padberg et al 2017) For neuronavigation, the subjects' head was coregistered with the standard brain of the brainsight software (Rogue Research Inc., Montreal, Canada). The center of the electrode was marked and placed over the dlPFC guided by an infrared system.…”

Section: Electrode Placement and Transcranial Direct Current Stimulatmentioning

confidence: 99%

Brain glucose uptake during transcranial direct current stimulation measured with functional [18F]FDG-PET

Kraus

Hahn

Sigurdardottir

et al. 2019

Brain Imaging and Behavior

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Previous evidence indicates that transcranial direct stimulation (tDCS) is a neuromodulatory brain stimulation technique. Easy applicability, low side-effects and negligible costs facilitated its wide-spread application in efforts to modulate the brain function, however neuronal mechanisms of tDCS are insufficiently understood. Hence, we investigated the immediate impact of tDCS on the brain's glucose consumption in a continuous infusion protocol with the radioligand [ 18 F]fluoro-2-deoxy-D-glucose ([ 18 F]FDG) and positron emission tomography (PET). This novel functional PET (fPET) method is capable to reliably detect area-specific and dynamic absolute glucose demand related to neuronal activity in a single molecular imaging session. Fifteen healthy subjects underwent tDCS at 0.5, 1 and 2 mA (mA) at the bilateral dorsolateral prefrontal cortex (dlPFC, cathodal right) for 10 min during functional [ 18 F]FDG-PET lasting 70 min. Active stimulation compared to sham did not yield significant changes in glucose consumption at any tested stimulation intensity in this paradigm. Exploratory investigation of aftereffects provided hints for increased glucose consumption with a delay of 5 min at 1 mA in the right posterior temporal cortex. This is the first study investigating changes of glucose consumption in the brain during tDCS. The lack of immediately increased glucose consumption indicates that energy demanding processes in the brain such as glutamatergic signaling might not be immediately increased by tDCS. However, our results implicate the need of fPET investigations for medium-term and long-term effects.

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Section: Electrode Placement and Transcranial Direct Current Stimulatmentioning

confidence: 99%

Brain glucose uptake during transcranial direct current stimulation measured with functional [18F]FDG-PET

Kraus

Hahn

Sigurdardottir

et al. 2019

Brain Imaging and Behavior

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“…In longitudinal studies, reproducibility in TES applications is relevant [12] and depends to a large extent on consistent positioning and placement. Generally, clinical studies are carried out by different operators, with different patients and in different places, thus the manual and unstable electrode placement has a negative effect on the reproducibility of the tests [13].…”

Section: Introductionmentioning

confidence: 99%

Novel flexible cap for application of transcranial electric stimulation: a usability study

Hunold

Ortega

Schellhorn

et al. 2020

Preprint

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BackgroundAdvances in transcranial electric stimulation (TES) were hampered by the conventional rubber electrodes manually attached to the head with rubber bands. This procedure limited montages to a few electrodes, was error prone with respect to electrode configurations and was burdensome for participants and operators. A newly developed flexible cap with integrated textile stimulation electrodes was compared to the conventional setup of rubber electrodes fixated by rubber bands, with respect to usability and reliability. Two operators applied both setups to twenty healthy volunteers participating in the study. Electrode position and impedance measures as well as subjective evaluations from participants and operators were obtained throughout the stimulation sessions. ResultsOur results demonstrated the superiority of the flexible cap by means of significantly higher electrode configuration reproducibility and a more efficient application. Both, operators and volunteers evaluated the flexible cap as easier to use and more comfortable to wear when compared to the conventional setup. ConclusionIn conclusion, the new cap improves existing and opens new applications scenarios for TES.

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“…Conventional interventions for MDD, such as pharmacological and cognitive behavioral therapy (Hadjistavropoulos, Alberts, Nugent, & Marchildon, ) have not been found to be effective in alleviating anhedonia. Despite the emergence of new interventions, such as ketamine (Price et al, ; Tizabi, Bhatti, Manaye, Das, & Akinfiresoye, ), repetitive magnetic stimulation (Loo & Mitchell, ), transcranial direct current stimulation (Padberg et al, ; Palm, Hasan, Strube, & Padberg, ), and deep brain stimulation (Kubu et al, ; Mi, ), most of these interventions are only applicable to patients with MDD in alleviating depressive symptoms. Recently, it has been recognized that subclinical depressive symptoms are prevalent in the general population (Chan, Wang, et al, ; Gao et al, ).…”

mentioning

confidence: 99%

Working memory training can improve anhedonia in college students with subsyndromal depressive symptoms

Zhang

Wang

et al. 2019

PsyCh Journal

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Anhedonia is defined as deficits in experiencing everyday life pleasure. Empirical studies suggest that anhedonia and working memory (WM) share overlapping neural substrates. Although WM training has been shown to alleviate anhedonia in individuals with social anhedonia, it is not clear whether WM training may also improve anhedonia in individuals with subsyndromal depression. This study examined the potential effect of WM training on improving anhedonia in college students with subsyndromal depression. Fifty college students were recruited and classified as the depressive (19 students) and non‐depressive (31 students) groups according to their scores on the Beck Depression Inventory. They then took part in a 20‐session dual n‐back WM training. All participants were requested to complete a set of measures capturing experiential pleasure and WM capacity both before and after the training. We found significant improvement in WM performance and self‐reported measures of experiential pleasure in both groups. However, only the depressive group showed significant improvement in a computer‐based task capturing motivation. These preliminary findings suggest that WM training may be able to alleviate anhedonia in individuals with subsyndromal depressive symptoms.

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Prefrontal transcranial direct current stimulation (tDCS) as treatment for major depression: study design and methodology of a multicenter triple blind randomized placebo controlled trial (DepressionDC)

Abstract: ClinicalTrials.gov Identifier NCT0253016.

Cited by 45 publications

References 60 publications

Brain glucose uptake during transcranial direct current stimulation measured with functional [18F]FDG-PET

Brain glucose uptake during transcranial direct current stimulation measured with functional [18F]FDG-PET

Novel flexible cap for application of transcranial electric stimulation: a usability study

Working memory training can improve anhedonia in college students with subsyndromal depressive symptoms

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