Prefrontal TMS produces smaller EEG responses than motor-cortex TMS: implications for rTMS treatment in depression

Kähkönen, Seppo; Komssi, Soile; Wilenius, Juha; Ilmoniemi, Risto J.

doi:10.1007/s00213-005-2197-3

Cited by 81 publications

(75 citation statements)

References 26 publications

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“…In addition, it is important to note that DLPFC stimulation does not evoke MEPs, and thus the finding that SICI and ICF produced consistent modulation of P60, regardless of the stimulated domain, indicates that these changes are unrelated to sensory feedback and instead related to SICI and ICF. The bidirectional changes in P60 TEP amplitude with SICI and ICF are further suggestive of bidirectional modulation of neural excitability, and are consistent with prior studies of their association with cortical excitability (Farzan et al, 2013;Ferreri et al, 2012;Kahkonen et al, 2005a;Rogasch et al, 2013).…”

Section: Limitationssupporting

confidence: 88%

Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS–EEG

Cash

Noda

Zomorrodi

et al. 2016

Neuropsychopharmacol

133

112

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Short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are noninvasive transcranial magnetic stimulation (TMS) measures of GABA A receptor-mediated inhibition and glutamatergic excitatory transmission, respectively. Conventionally these measures have been restricted to the motor cortex. We investigated whether SICI and ICF could be recorded from the dorsolateral prefrontal cortex (DLPFC) using combined TMS and electroencephalography (TMS-EEG). We first characterized the neural signature of SICI and ICF in M1 in terms of TMS-evoked potentials (TEPs) and spectral power modulation. Subsequently, these paradigms were applied in the DLPFC to determine whether similar neural signatures were evident. With TMS at M1, SICI and ICF led to bidirectional modulation (inhibition and facilitation, respectively) of P30 and P60 TEP amplitude, which correlated with MEP amplitude changes. With DLPFC stimulation, P60 was bidirectionally modulated by SICI and ICF in the same manner as for M1 stimulation, whereas P30 was absent. The sole modulation of early TEP components is in contradistinction to other measures such as long-interval intracortical inhibition and may reflect modulation of short latency excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs). Overall, the data suggest that SICI and ICF can be recorded using TMS-EEG in DLPFC providing noninvasive measures of glutamatergic and GABA A receptor-mediated neurotransmission. This may facilitate future research attempting to ascertain the role of these neurotransmitters in the pathophysiology and treatment of neurological and psychiatric disorders.

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Section: Limitationssupporting

confidence: 88%

Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS–EEG

Cash

Noda

Zomorrodi

et al. 2016

Neuropsychopharmacol

133

112

View full text Add to dashboard Cite

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“…The characteristics of the EEG response to TMS may depend on the intensity of stimulation (Komssi et al, 2004;Kähkönen et al, 2005a), and different corticothalamic modules may have different thresholds and reactivity to TMS (Kähkönen et al, 2005b). Thus, the site-specificity of the natural frequency may be an intensity-dependent phenomenon and may be lost at high stimulation intensities.…”

Section: The Local Natural Frequency Is Preserved Across a Wide Rangementioning

confidence: 99%

Natural Frequencies of Human Corticothalamic Circuits

Rosanova

Casali

Bellina

et al. 2009

Journal of Neuroscience

614

636

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The frequency tuning of a system can be directly determined by perturbing it and by observing the rate of the ensuing oscillations, the so called natural frequency. This approach is used, for example, in physics, in geology, and also when one tunes a musical instrument. In the present study, we employ transcranial magnetic stimulation (TMS) to directly perturb a set of selected corticothalamic modules (Brodmann areas 19, 7, and 6) and high-density electroencephalogram to measure their natural frequency. TMS consistently evoked dominant ␣-band oscillations (8 -12 Hz) in the occipital cortex, ␤-band oscillations (13-20 Hz) in the parietal cortex, and fast ␤/␥-band oscillations (21-50 Hz) in the frontal cortex. Each cortical area tended to preserve its own natural frequency also when indirectly engaged by TMS through brain connections and when stimulated at different intensities, indicating that the observed oscillations reflect local physiological mechanisms. These findings were reproducible across individuals and represent the first direct characterization of the coarse electrophysiological properties of three associative areas of the human cerebral cortex. Most importantly, they indicate that, in healthy subjects, each corticothalamic module is normally tuned to oscillate at a characteristic rate. The natural frequency can be directly measured in virtually any area of the cerebral cortex and may represent a straightforward and flexible way to probe the state of human thalamocortical circuits at the patient's bedside.

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“…Recent advances in TMS-EEG co-registration in humans and animals may enhance clinical and translational TMS/rTMS applications [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59]. At the time of this writing, TMS-EEG is still mostly used in human nonclinical studies of cortical excitability and connectivity, and has not been extensively applied in patient populations or animal disease models.…”

Section: Standard Tms Parameters and The Novelty Of Tms-eeg Co-registmentioning

confidence: 99%

New Perspectives in Transcranial Magnetic Stimulation: Epilepsy, Consciousness and the Perturbational Approach

Manganotti

Felice

2013

Behavioural Neurology

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Abstract. Transcranial magnetic stimulation (TMS) evolved from a simple method to stimulate the motor cortex to an invaluable tool for multiple diagnostic, research, and therapeutic applications. A further development of this noninvasive brain stimulation technique is concomitant electroencephalographic (EEG) recording during TMS. The theoretical underpinnings and the technological innovation of TMS-EEG co-registration have opened new ways to study brain excitability in neurological conditions previously investigated with conventional EEG alone. A further advance in TMS research applications is the perturbational approach: magnetic pulses can interfere not only with dynamic, often pathological rhythms in epilepsy or altered consciousness states, but also modulate physiological states such as sleep and sleep deprivation. So applied, TMS-EEG co-registration can reveal different neurophysiological and behavioral patterns in the awake state, sleep or sleep deprivation. In this review, we discuss the use of TMS and TMS-EEG co-registration in epilepsy, a still rather limited although promising area of study.

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Prefrontal TMS produces smaller EEG responses than motor-cortex TMS: implications for rTMS treatment in depression

Abstract: This study provides further evidence that the prefrontal and motor cortices have different reactivity to TMS, but the MT may be used for determining the stimulus intensity of prefrontal rTMS treatment in depression, at least at motor threshold intensities or near to it.

Cited by 81 publications

References 26 publications

Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS–EEG

Characterization of Glutamatergic and GABAA-Mediated Neurotransmission in Motor and Dorsolateral Prefrontal Cortex Using Paired-Pulse TMS–EEG

Natural Frequencies of Human Corticothalamic Circuits

New Perspectives in Transcranial Magnetic Stimulation: Epilepsy, Consciousness and the Perturbational Approach

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