Prefrontal Theta Cordance in the Prediction of Antidepressant Response to Various Classes of Antidepressants in Patients with Depressive Disorder

Abstract

Introduction and objectivesPrevious studies demonstrated efficacy of reduction of QEEG prefrontal theta cordance (RC) after the first week of treatment in the prediction of antidepressant response.AimsThe study aimed to compare the ability of RC in the prediction of response to various antidepressant classes.MethodsAll patients (n = 142) were treated with antidepressants (SSRI-58, SNRI-47, NDRI-22, NaSSA-15) for ≥ 4 weeks. Response was defined as MADRS reduction ≥ 50%. EEG were performed at baseline and week 1 of treatment and cordance was calculated for 3 prefrontal electrodes (Fp1, Fp2, Fz).ResultsLogistic regression identified RC as a predictor of response to SSRI, SNRI and NDRI but not for NaSSA. Predictive parameters of RC for response to mentioned antidepressant classes are displayed in the Table 1.Areas under curves of ROC analysis (AUC) of RC for response prediction were not significantly different among antidepressant classes.ConclusionThe predictive efficacy of RC for response to SSRI, SNRI and NDRI was comparable.This study was supported by the grants of MH CZ nr.15-29900A, MH CZ – DRO (NIMH-CZ, 00023752) and by the project Nr. LO1611 from the MEYS under the NPU I program.