Prefrontal cortex in humans and apes: A comparative study of area 10

Semendeferi, Katerina; Armstrong, Este; Schleicher, Axel; Zilles, Karl; Hoesen, Gary W. Van

doi:10.1002/1096-8644(200103)114:3<224::aid-ajpa1022>3.3.co;2-9

Cited by 141 publications

(179 citation statements)

References 19 publications

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“…This is perhaps unsurprising given the degree of evolutionary expansion in this region [Semendeferi et al, 2001] and supports our findings of interspecies differences. It is important to remember that tractography does not inform us about precise nature of the synaptic connections made between two areas or their functional significance.…”

Section: Discussionsupporting

confidence: 90%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

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The periaqueductal gray matter (PAG) is a midbrain structure, involved in key homeostatic neurobiological functions, such as pain modulation and cardiorespiratory control. Animal research has identified four subdivisional columns that differ in both connectivity and function. Until now these findings have not been replicated in humans. This study used high‐resolution brainstem optimized diffusion magnetic resonance imaging and probabilistic tractography to segment the human PAG into four subdivisions, based on voxel connectivity profiles. We identified four distinct subdivisions demonstrating high spatial concordance with the columns of the animal model. The resolution of these subdivisions for individual subjects permitted detailed examination of their structural connectivity without the requirement of an a priori starting location. Interestingly patterns of forebrain connectivity appear to be different to those found in nonhuman studies, whereas midbrain and hindbrain connectivity appears to be maintained. Although there are similarities in the columnar structure of the PAG subdivisions between humans and nonhuman animals, there appears to be different patterns of cortical connectivity. This suggests that the functional organization of the PAG may be different between species, and as a consequence, functional studies in nonhumans may not be directly translatable to humans. This highlights the need for focused functional studies in humans. Hum Brain Mapp 36:3459–3471, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 90%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

View full text Add to dashboard Cite

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“…Area 10 is activated when an expected financial reward is received (Knutson, et al 2003). Area 10 is both absolutely and relatively much larger in humans than in other primates which suggests that some of the circuitry related to economic decision-making is a phylogenetic specialization in the human brain (Allman et al, 2002;Semendeferi et al, 2001). …”

Section: Discussionmentioning

confidence: 99%

Mental processes and strategic equilibration: An fMRI study of selling strategies in second price auctions

et al. 2007

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This study is the first to attempt to isolate a relationship between cognitive activity and equilibration to a Nash Equilibrium. Subjects, while undergoing fMRI scans of brain activity, participated in second price auctions against a single competitor following predetermined strategy that was unknown to the subject. For this auction there is a unique strategy that will maximize the subjects’ earnings, which is also a Nash equilibrium of the associated game theoretic model of the auction. As is the case with all games, the bidding strategies of subjects participating in second price auctions most often do not reflect the equilibrium bidding strategy at first but with experience, typically exhibit a process of equilibration, or convergence toward the equilibrium. This research is focused on the process of convergence. In the data reported here subjects participated in sixteen auctions, after which all subjects were told the strategy that will maximize their revenues, the theoretical equilibrium. Following that announcement, sixteen more auctions were performed. The question posed by the research concerns the mental activity that might accompany equilibration as it is observed in the bidding behavior. Does brain activation differ between being equilibrated and non-equilibrated in the sense of a bidding strategy? If so, are their differences in the location of activation during and after equilibration? We found significant activation in the frontal pole especially in Brodmann’s area 10, the anterior cingulate cortex, the amygdala and the basal forebrain. There was significantly more activation in the basal forebrain and the anterior cingulate cortex during the first sixteen auctions than in the second sixteen. The activity in the amygdala shifted from the right side to the left after the solution was given. Copyright Economic Science Association 2007Experiments, Auctions,

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“…Claims about particular social adaptations in primates, and their linkage with particular cortical regions (area 10; area 13), are aspects of the continuing debate about the modular or distributed nature of cortical evolution (Semendeferi et al 1998(Semendeferi et al , 2001Holloway 2002). Several characterizations of frontal cortex exist, from a mosaic of areas each concerned with a particular spatio-temporal computation (Goldman-Rakic 1995) to a region with distributed, overlapping abilities for a wide variety of problems involving working memory, selective attention and inhibition, and weighing of past contingencies (Duncan & Owen 2000).…”

Section: (Iii) Regressionmentioning

confidence: 99%

Peripheral variability and central constancy in mammalian visual system evolution

et al. 2005

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Neural systems are necessarily the adaptive products of natural selection, but a neural system, dedicated to any particular function in a complex brain, may be composed of components that covary with functionally unrelated systems, owing to constraints beyond immediate functional requirements. Some studies support a modular or mosaic organization of the brain, whereas others emphasize coordination and covariation. To contrast these views, we have analysed the retina, striate cortex (V1) and extrastriate cortex (V2, V3, MT, etc.) in 30 mammals, examining the area of the neocortex and individual neocortical areas and the relative numbers of rods and cones. Controlling for brain size and species relatedness, the sizes of visual cortical areas (striate, extrastriate) within the brains of nocturnal and diurnal mammals are not statistically different from one another. The relative sizes of all cortical areas, visual, somatosensory and auditory, are best predicted by the total size of the neocortex. In the sensory periphery, the retina is clearly specialized for niche. New data on rod and cone numbers in various New World primates confirm that rod and cone complements of the retina vary substantially between nocturnal and diurnal species. Although peripheral specializations or receptor surfaces may be highly susceptible to niche-specific selection pressures, the areal divisions of the cerebral cortex are considerably more conservative.

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Prefrontal cortex in humans and apes: A comparative study of area 10

Cited by 141 publications

References 19 publications

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Mental processes and strategic equilibration: An fMRI study of selling strategies in second price auctions

Peripheral variability and central constancy in mammalian visual system evolution

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