Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

Chen, Peng; Lou, Sha; Huang, Zhao-Huan; Wang, Zhenni; Shan, Qing-Hong; Wang, Yu; Yang, Yupeng; Li, Xiangning; Gong, Hui; Jin, Yan; Zhi, Zhang; Zhou, Jiang‐Ning

doi:10.1016/j.neuron.2020.01.033

Cited by 67 publications

(44 citation statements)

References 73 publications

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“…S3 C, D), indicating that the AAV-helper carrying TVA had a slightly leaky expression, which was consistent with previous studies 26 . Furthermore, previous studies 9 , 16 have shown that CRH-Cre mice crossed with Cre-dependent reporter mice allowed for accurate characterisation of the distribution of CRH neurons. To detect leakage of the AAV-helper carrying BFP, we injected AAV-helpers in into the M1 of CRH-Cre:LSL-H2B-GFP mice, the soma of CRH neurons which express GFP.…”

Section: Resultsmentioning

confidence: 99%

“…5 C), indicating that the BF may regulate cortical CRH neurons mainly through cholinergic neurons. As stress is a complex physiological response involving a variety of behaviours, and both CRH neurons and CNBF contribute to stress 16 , 56 , we suppose that the regulation of CNBF on CRH neurons in different cortical regions may participate in various functions related to stress.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, those in the sensorimotor cortex contribute to depressant-like function by modulating motor activity during stress 14 , whereas overexpression of CRH in the frontal cortex decreases locomotor and exploratory activity and produces an anxiolytic-like effect 15 . Interestingly, recent studies 16 have verified the key role of CRH neurons in the medial prefrontal cortex (mPFC) in controlling behavioural-style selection during various stressful challenges.…”

Section: Introductionmentioning

confidence: 99%

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Long-range inputome of cortical neurons containing corticotropin-releasing hormone

Zhao

Wang

et al. 2020

Sci Rep

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Dissection of the neural circuits of the cerebral cortex is essential for studying mechanisms underlying brain function. Herein, combining a retrograde rabies tracing system with fluorescent micro-optical sectional tomography, we investigated long-range input neurons of corticotropin-releasing hormone containing neurons in the six main cortical areas, including the prefrontal, somatosensory, motor, auditory, and visual cortices. The whole brain distribution of input neurons showed similar patterns to input neurons distributed mainly in the adjacent cortical areas, thalamus, and basal forebrain. Reconstruction of continuous three-dimensional datasets showed the anterior and middle thalamus projected mainly to the rostral cortex whereas the posterior and lateral projected to the caudal cortex. In the basal forebrain, immunohistochemical staining showed these cortical areas received afferent information from cholinergic neurons in the substantia innominata and lateral globus pallidus, whereas cholinergic neurons in the diagonal band nucleus projected strongly to the prefrontal and visual cortex. Additionally, dense neurons in the zona incerta and ventral hippocampus were found to project to the prefrontal cortex. These results showed general patterns of cortical input circuits and unique connection patterns of each individual area, allowing for valuable comparisons among the organisation of different cortical areas and new insight into cortical functions.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-range inputome of cortical neurons containing corticotropin-releasing hormone

Zhao

Wang

et al. 2020

Sci Rep

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“…In human beings, the symptoms of passive coping response are referred to as hopelessness, which is a core feature of major depressive disorder. It has been shown that mPFC also plays a role in the control of the passive coping response to behavioral challenge 20‐22,29 . By using pharmacological and shRNA interventions, our previous study demonstrates an involvement of P2X2 receptors in the mPFC in the ATP modulation of passive coping response 12 .…”

Section: Discussionmentioning

confidence: 86%

“…The FST and TST are widely employed to evaluate the despair aspect of depression‐like behavior and screen antidepressants in rodents, 18 but recently researchers prefer to interpret the acquisition of immobility in the FST as behavioral adaptation to the acute stressor which represents an adaptive cognitive process or as passive coping response or inhibition of active coping response 19‐22 . In this study, we used the FST and TST to measure passive coping response to behavioral challenge.…”

Section: Resultsmentioning

confidence: 99%

Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge

Kong

Wang

et al. 2020

Genes Brain and Behavior

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P2X2 and P2X3 receptors are widely expressed in both the peripheral nervous system and the central nervous system and have been proven to participate in different peripheral sensory functions, but there are few studies on the involvement of P2X2 and P2X3 receptors in animal behaviors. Here we used P2X2 and P2X3 knockout mice to address this issue. P2X2 knockout mice showed normal motor function, exploratory behavior, anxiety‐like behaviors, learning and memory behaviors and passive coping response to behavioral challenge. Nevertheless, the effect of ATP infusion in the medial prefrontal cortex (mPFC) on the passive coping response was blocked by P2X2 but not P2X3 receptor deletion. Additionally, no deficits in a wide variety of behavioral tests were observed in P2X3 knockout mice. These findings demonstrate a role of P2X2 receptor in the mPFC in adenosine‐5′‐triphosphate modulation of the passive coping response to behavioral challenge and show that the P2X2/P2X3 receptor is dispensable for behaviors.

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Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex‐Wide Opto‐Electrophysiological Recordings

Donaldson

Navabi

Carter

et al. 2022

Adv Healthcare Materials

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Electrophysiology and optical imaging provide complementary neural sensing capabilities – electrophysiological recordings have high temporal resolution, while optical imaging allows recording of genetically‐defined populations at high spatial resolution. Combining these two modalities for simultaneous large‐scale, multimodal sensing of neural activity across multiple brain regions can be very powerful. Here, transparent, inkjet‐printed electrode arrays with outstanding optical and electrical properties are seamlessly integrated with morphologically conformant transparent polymer skulls. Implanted on transgenic mice expressing the Calcium (Ca2+) indicator GCaMP6f in excitatory neurons, these “eSee‐Shells” provide a robust opto‐electrophysiological interface for over 100 days. eSee‐Shells enable simultaneous mesoscale Ca2+ imaging and electrocorticography (ECoG) acquisition from multiple brain regions covering 45 mm2 of cortex under anesthesia and in awake animals. The clarity and transparency of eSee‐Shells allow recording single‐cell Ca2+ signals directly below the electrodes and interconnects. Simultaneous multimodal measurement of cortical dynamics reveals changes in both ECoG and Ca2+ signals that depend on the behavioral state.

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Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

Abstract: Highlights d Prefrontal CRF GABAergic interneurons are recruited during behavioral challenges d Manipulation of CRF neurons motivates selection of behavioral styles under challenges d Activation of CRF neurons promotes persistent stressresistant behaviors

Cited by 67 publications

References 73 publications

Long-range inputome of cortical neurons containing corticotropin-releasing hormone

Long-range inputome of cortical neurons containing corticotropin-releasing hormone

Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge

Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex‐Wide Opto‐Electrophysiological Recordings

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