Prefrontal cortex activity differentiates processes affecting memory in depression

Nitschke, Jack B.; Heller, Wendy; Etienne, Marci A.; Miller, Gregory A.

doi:10.1016/j.biopsycho.2004.03.004

Cited by 53 publications

(47 citation statements)

References 57 publications

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“…1 Such observations are consistent with cognitive theories of depression which suggest that a negative emotional bias may be important in the aetiology and maintenance of depression, 2 with Cognitive Behavioural Therapy (CBT) explicitly seeking to reverse this negative bias. 3 Although there has been little interface between pharmacological and cognitive theories of depression to date, recent behavioural data suggest that antidepressant administration modulates emotional processing in a manner consistent with these cognitive theories of depression.…”

Section: Introductionsupporting

confidence: 70%

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

et al. 2007

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Recent neuropsychological studies in healthy volunteers suggest that antidepressants enhance the processing of positive emotional information. However, the neural substrates underpinning these changes have not been fully elucidated. The current study, therefore, used functional magnetic resonance imaging (fMRI) to map brain systems activated during successful categorization and subsequent recognition of self-referent positive and negative personality characteristics in healthy volunteers following short-term (7 days) repeated administration of the selective noradrenergic reuptake inhibitor reboxetine. Twenty-four healthy volunteers were randomly assigned to 7-day double-blind intervention with reboxetine or placebo. On day 7, neural responses during the categorization and subsequent recognition of positive and negative characteristics were assessed using fMRI. Questionnaires monitoring mood, hostility and anxiety were given before and during this intervention. During categorization, reboxetine was associated with greater activation to positive words, relative to negative words, in left precuneus and right inferior frontal gyrus. By contrast, at subsequent recognition reboxetine was associated with reduced response to positive words, relative to negative words, in left precuneus, anterior cingulate and medial frontal gyrus. These changes in the neural processing of positive and negative words occurred in the absence of significant differences in ratings of mood and anxiety. Such adaptations in the neural processing of emotional information support the hypothesis that antidepressants have early effects on emotional processing in a manner which would be expected to reverse negative biases in depression.

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Section: Introductionsupporting

confidence: 70%

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

et al. 2007

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“…A similar imbalance of function is shown in the activity of the PFC that affects memory processing in MD (Nitschke, Heller, Etienne, & Miller, 2004). Numerous electroencephalography (EEG) and neuroimaging studies have reported more right than left PFC activity in depression, indicating hypoactivity in the left DLPFC and hyperactivity in the right DLPFC (Grimm et al, 2008;Nitschke et al, 2004).…”

Section: Introductionmentioning

confidence: 81%

Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex of Major Depression: Improving Visual Working Memory, Reducing Depressive Symptoms

Salehinejad

Rostami²,

Ghanavati³

2015

NeuroRegulation

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Recent studies on major depression (MD) have used noninvasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) to improve impaired emotion and cognition in MD. However, such experiments have yielded mixed results, specifically with respect to cognition in MD. This study aimed to investigate whether anodal and cathodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) would significantly improve visual working memory and reduce depressive symptoms in patients with MD. Thirty patients with major depression (n = 30) were randomly assigned to receive either experimental (active) or control (sham) tDCS. To measure cognitive functions, the participants underwent a series of visual memory neuropsychological tasks; and to measure depression symptoms, the Beck Depression Inventory (BDI) and Hamilton Depression Scale (HDRS) were used. The parameters of active tDCS included 2 mA for 20 min per day for 10 consecutive days, anode over the left DLPFC (F3), cathode over the right DLPFC (F4) region. After 10 sessions of anodal and cathodal tDCS, patients showed significantly improved performance in visual working memory tasks. The same results were observed for depression symptoms. This study showed that anodal tDCS over left DLPFC, concurrently with cathodal tDCS over right DLPFC, improved cognitive impairment (specifically visual working memory), as well as reduced depressive symptoms in patients with MD. This finding provides evidence that supports effectiveness of a specific montage of tDCS to improve impaired cognition in MD, specifically in visual working memory.

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“…Electroencephalographic (EEG) studies have shown that MDD is associated with less left than right PFC activity during preparation for a sad narrative (Nitschke et al 2004), consistent with previous findings of an association between damage in the left PFC and secondary depressive syndromes (Sackeim et al 1982). Further evidence from PET (Martinot et al 1990), transcranial magnetic stimulation (TMS ; Bajwa et al 2008) and fMRI (Keedwell et al 2005 ;Johnstone et al 2007 ;Grimm et al 2008) studies have also indicated that frontal functional asymmetry is probably important in the neuropathophysiology of MDD (Sackeim et al 1982), with possibly greater dysfunction in the left PFC versus the right PFC.…”

Section: Introductionmentioning

confidence: 99%

Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

et al. 2012

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Tang, Y.; Kong, L.; Womer, F.; Jiang, W.; Cao, Y.; Ren, L.; Wang, J.; Fan, G.; Blumberg, H. P.; Xu, K.; and Wang, F., ,"Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: A resting-state functional magnetic resonance imaging study. " Psychological Medicine.43,9. 1921-1927. (2012 Background. Convergent studies provide support for abnormalities in the structure and functioning of the prefrontal cortex (PFC) and the amygdala, the key components of the neural system that subserves emotional processing in major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala-PFC functional connectivity abnormalities in treatment-naive subjects with MDD.Methods. Resting-state fMRI data were acquired from 28 individuals with MDD and 30 healthy control (HC) subjects. Amygdala-PFC functional connectivity was compared between the MDD and HC groups.Results. Decreased functional connectivity to the left ventral PFC (VPFC) from the left and right amygdala was observed in the MDD group, compared with the HC group (p<0.05, corrected).Conclusions. The treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the left VPFC. This suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.

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Prefrontal cortex activity differentiates processes affecting memory in depression

Cited by 53 publications

References 57 publications

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study

Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex of Major Depression: Improving Visual Working Memory, Reducing Depressive Symptoms

Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

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