Prefrontal asymmetry predicts affect, but not beliefs about affect

Steiner, Amanda R.W.; Coan, James A.

doi:10.1016/j.biopsycho.2011.06.010

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…The 5-HTTLPR genotype may be more closely related to withdrawal motivation than to current mood per se. The self-report rating may also have captured situational or identity-related beliefs about what one ought to have felt, and to a lesser extent the actual emotional and motivational states during viewing the film, with the latter showing generally more clear relationships to biological variables (Steiner & Coan, 2011). This effect might have been amplified by introducing some temporal distance between the film and the ratings through the study design.…”

Section: Discussionmentioning

confidence: 99%

Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.

Papousek

Reiser²,

Schulter³

et al. 2013

Emotion

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Growing literature indicates that emotional reactivity and regulation are strongly linked to genetic modulation of serotonergic neurotransmission. However, until now, most studies have focused on the relationship between genotypic markers, in particular the serotonin transporter-linked polymorphic region (5-HTTLPR), and neural structures using MRI. The current study aimed to bridge the gap between the relevant MRI literature on the effects of the 5-HTTLPR genotype and the research tradition focusing on transient lateralized changes of electrocortical activity in the prefrontal cortex using electroencephalography (EEG). Lateral shifts of EEG alpha asymmetry in response to an aversive film consisting of scenes of real injury and death were assessed in healthy participants (n = 165). To evaluate the specificity of the 5-HTTLPR effect, participants were also tested for the COMT Val158Met polymorphism which is linked to dopamine inactivation. While viewing the film, individuals homozygous for the 5-HTTLPR short allele displayed a clear lateral shift of dorsolateral frontal activity to the right, which was virtually absent in participants carrying the long allele. The heightened electrocortical response to the aversive stimulation and its direction indicates a greater propensity of s/s homozygotes to experience withdrawal oriented affect in response to negative emotion cues in the environment. Moreover, together with previous research the findings support the notion of a link between the serotonergic system and self-regulation related to avoidance motivation, and a link between the dopaminergic system and self-regulation related to approach motivation.

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Section: Discussionmentioning

confidence: 99%

Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.

Papousek

Reiser²,

Schulter³

et al. 2013

Emotion

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show abstract

“…Although one study suggests that frontal asymmetry is not correlated with depressive symptoms in MDD− college students one year later (Blackhart, Minnix, & Kline, 2006), no clinical interview was performed to determine presence or absence of DSM-IV (American Psychiatric Association, 1994) disorders at baseline, so it is possible that participants had symptoms that could have influenced null results. In contrast, lower left than right frontal activity at rest is linked to future depression symptoms one year later in two adolescent MDD− samples after controlling for baseline depressive symptoms (Mitchell & Pössel, 2012; Pössel, Lo, Fritz, & Seemann, 2008), and prospectively is related to self-reported freshman-year home-sickness (Steiner & Coan, 2011). Furthermore, lower left than right resting frontal activity is associated with first-episode MDD onset within three years in 40 MDD− adults thought to be at risk for developing mood disorders: 3 participants subsequently met criteria for a major depressive episode and 10 met criteria for a minor depressive episode during this period (Nusslock et al, 2011).…”

Section: Introductionmentioning

confidence: 88%

Resting frontal brain asymmetry is linked to future depressive symptoms in women

Stewart

Allen

2018

Biological Psychology

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This longitudinal pilot study examined whether baseline resting frontal electroencephalographic (EEG) asymmetry correlates with depressive symptoms during the most impaired two-week period in the following year. Current-source-density (CSD) transformed resting frontal EEG asymmetry, severity of depression symptoms (Beck Depression Inventory - II), and stress (indexed by negative life events; NLE) were recorded in never-depressed young adults with no current DSM-IV diagnosis (38 women, 16 men) at baseline. One year later, depression symptoms and NLEs experienced during the interim were assessed. Individuals who reported greater interim NLEs also endorsed interim higher depression symptoms, a pattern that replicated when first accounting for baseline stress and depression. For women, higher depression reported at follow-up was linked to lower left than right frontal EEG activity at baseline, a pattern that replicated when first accounting for depressive symptoms at baseline. Despite the modest sample size of the present analysis, findings are consistent with prior reports of sex differences in patterns of brain laterality and support the idea that CSD-referenced EEG asymmetry may be a risk marker for future depression in previously healthy young women.

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“…Less relative left frontal activity during rest predicted decreased neurophysiological change on subsequent emotional tasks [13], and less relative left frontal activity during negative films predicted mood deterioration in the next week [14]. Additionally, frontal asymmetry has predictive power over longer time frames: less relative left frontal activity predicted depressive symptoms in adolescent boys a year later [15] and also predicted self-reported homesickness among college freshman [16]. …”

Section: The Predictive Power Of Frontal Asymmetrymentioning

confidence: 99%

Frontal EEG asymmetry as a promising marker of depression vulnerability: summary and methodological considerations

Allen

Reznik

2015

Current Opinion in Psychology

152

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Frontal EEG asymmetry is a promising neurophysiological marker of depression risk. It predicts emotional response and negative affect hours to years later. Yet, inconsistencies in the literature may be due to differing methodological approaches between research groups. Within the past two years, a number of studies have shown this line of research may be strengthened by augmenting resting assessments with emotionally evocative tasks, utilizing optimal recording montages, and taking an integrative neuroscience approach that links frontal asymmetry to other indices of neural function. This review will focus on recent work in frontal asymmetry and depression with a particular focus on promising future directions and methodological considerations that may increase consistency between research groups.

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Prefrontal asymmetry predicts affect, but not beliefs about affect

Cited by 15 publications

References 25 publications

Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.

Serotonin transporter genotype (5-HTTLPR) and electrocortical responses indicating the sensitivity to negative emotional cues.

Resting frontal brain asymmetry is linked to future depressive symptoms in women

Frontal EEG asymmetry as a promising marker of depression vulnerability: summary and methodological considerations

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