Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide

Heeringen, Cornelis Van; Audenaert, Kurt; Laere, K. Van; Dumont, Filip; Slegers, Guido; Mertens, John; Dierckx, Rudi

doi:10.1016/s0165-0327(01)00482-7

Cited by 180 publications

(106 citation statements)

References 37 publications

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“…Most recently, 5-HT 2A receptor binding and harm avoidance were shown to be negatively correlated in the frontal cortex in healthy subjects (Moresco et al, 2002) and in the prefrontal cortex in patients that attempted suicide (van Heeringen et al, 2003). We found […”

Section: Only Rec An Have Reduced [mentioning

confidence: 73%

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

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Price

Meltzer

et al. 2004

Neuropsychopharmacol

153

107

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Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT 2A ) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, 41 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT 2A 18 F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.

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Section: Only Rec An Have Reduced [mentioning

confidence: 73%

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Bailer

Price

Meltzer

et al. 2004

Neuropsychopharmacol

153

107

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“…For ill AN subjects, [ 18 F]altanserin BP was positively related to harm avoidance in the suprapragenual cingulate, frontal, and parietal regions. 5-HT 2A receptor binding and harm avoidance were shown to be negatively correlated in the frontal cortex in healthy subjects (180) and in the prefrontal cortex in patients that attempted suicide (181).…”

Section: -Ht Da and Harm Avoidancementioning

confidence: 95%

Neurobiology of anorexia and bulimia nervosa

Kaye

2008

Physiology & Behavior

519

369

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“…A total of six published studies have used PET or single photon emission computed tomography to examine the correlation of serotonergic neurotransmission with HA (Rabiner et al 2002 ;Moresco et al 2002 ;Borg et al 2003 ;Van Heeringen et al 2003 ;Reimold et al 2008 ;Karlsson et al 2009 (Rabiner et al 2002 ;Borg et al 2003 ;Karlsson et al 2009) and one examining serotonin transporter 5-HTT with (Reimold et al 2008) in healthy subjects found no correlation between serotonin function and HA.…”

Section: Introductionmentioning

confidence: 99%

Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort

et al. 2012

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Tuominen, L.; Salo, J.; Hirvonen, J.; Någren, K.; Laine, P.; Melartin, T.; Isometsä, E.; Viikari, J.; Cloninger, C. R.; Raitakari, O.; Hietala, J.; and Keltikangas-Järvinen, L., ,"Temperament, character and serotonin activity in the human brain: A positron emission tomography study based on a general population cohort." Psychological Medicine. 43,4. 881-894. (2012 Background. The psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension ' harm avoidance ' (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an ' oversampling ' study design.Method. Subjects consistently in either upper or lower quartiles for the HA trait were selected from a populationbased cohort in Finland (n=2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high-and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BP ND ) in high-and low-HA groups estimated with PET and [ 11 C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([ 11 C]MADAM). In secondary analyses, 5-HTT BP ND was correlated with other TCI dimensions.Results. 5-HTT BP ND did not differ between high-and low-HA groups in the midbrain or any other brain region. This result remained the same even after adjusting for other relevant TCI dimensions. Higher 5-HTT BP ND in the raphe nucleus predicted higher scores in ' self-directedness '.Conclusions. This study does not support an association between the temperament dimension HA and serotonin transporter density in healthy subjects. However, we found a link between high serotonin transporter density and high ' self-directedness ' (ability to adapt and control one's behaviour to fit situations in accord with chosen goals and values). We suggest that biological factors are more important in explaining variability in character than previously thought.

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Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide

Cited by 180 publications

References 37 publications

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Neurobiology of anorexia and bulimia nervosa

Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort

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