Preformulation Study of Epigallocatechin Gallate, a Promising Antioxidant for Topical Skin Cancer Prevention

Proniuk, Stefan; Liederer, Bianca M.; Blanchard, James

doi:10.1002/jps.10009

Cited by 68 publications

(44 citation statements)

References 10 publications

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“…Thus, although potential synergistic effects must be evaluated, simple mixing of EGCG or GTPPs with other antioxidants may not increase stability. 90 An earlier study that tested 10% EGCG in hydrophilic ointment United States Pharmacopeia suggested that addition of 0.1% butylated hydroxytoluene to this formulation boosted the stability significantly. 38 These types of formulations, with combined active compounds, are still to be evaluated in human trials.…”

Section: Future Perspectivementioning

confidence: 97%

“…75 Oxidative damage induced by UVB may also cause modifications of proteins, eg, collagen crosslinking and formation of carbonyl derivatives, which Expression of green tea targeted genes in response to (ÿ)-epigallocatechin-3-gallate (EGCG) exposure in human epidermal keratinocytes, based on previously published findings. 12,57,67,90 Certain cell growth regulating genes are inhibited, major markers for keratinocyte differentiation are up-regulated, whereas many genes coded for proapoptosis factors are suppressed. Only epidermis is shown.…”

Section: Potential Applications For Antiphotoagingmentioning

confidence: 99%

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Green tea and the skin

Hsu

2005

Journal of the American Academy of Dermatology

235

127

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Section: Future Perspectivementioning

confidence: 97%

Section: Potential Applications For Antiphotoagingmentioning

confidence: 99%

Green tea and the skin

Hsu

2005

Journal of the American Academy of Dermatology

235

127

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“…Several studies have shown that EGCG could merely be active in a narrow range of pH and otherwise degraded. 36,37 It is also remarkable that …”

Section: Discussionmentioning

confidence: 99%

The therapeutic effects of MSc1 nanocomplex, synthesized by nanochelating technology, on experimental autoimmune encephalomyelitic C57/BL6 mice

Fakharzadeh¹,

Sahraian²,

Hafizi³

et al. 2014

IJN

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Purpose Currently approved therapies for multiple sclerosis (MS) at best only slow down its progression. Therefore, it is necessary to utilize novel technologies in order to synthesize smart multifunctional structures. In the present study, for the first time we evaluated the therapeutic potential of MSc1 nanocomplex, which was designed based on novel nanochelating technology. Materials and methods MSc1 cell-protection capacity, with and without iron bond, was evaluated against hydrogen peroxide (H 2 O 2 )-induced oxidative stress in cultured rat pheochromocytoma-12 cells. The ability of MSc1 to maintain iron bond at pH ranges of 1–7 was evaluated. Nanocomplex toxicity was examined by estimating the intraperitoneal median lethal dose (LD 50 ). Experimental autoimmune encephalomyelitic mice were injected with MSc1 14 days after disease induction, when the clinical symptoms appeared. The clinical score, body weight, and disease-induced mortality were monitored until day 54. In the end, after collecting blood samples for assessing hemoglobin and red blood cell count, the brains and livers of the mice were isolated for hematoxylin and eosin staining and analysis of iron content, respectively. Results The results showed that MSc1 prevented H 2 O 2 -induced cell death even after binding with iron, and it preserved its bond with iron constant at pH ranges 1–7. The nanocomplex intraperitoneal LD 50 was 1,776.59 mg/kg. MSc1 prompted therapeutic behavior and improved the disabling features of experimental autoimmune encephalomyelitis, which was confirmed by decreased clinical scores versus increased body mass and 100% survival probability. It did not cause any adverse effects on hemoglobin or red blood cell count. Histopathological studies showed no neural loss or lymphocyte infiltration in MSc1-treated mice, while the hepatic iron content was also normal. Conclusion These results demonstrate that MSc1 could be a promising beneficial novel agent and has the capacity to be evaluated in further studies.

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“…Skin application formulations that enhance the stability of EGCG are also being investigated, and it appears that glycerin formulated products show promise in this area. 130 …”

Section: Gtp Bioavailabilitymentioning

confidence: 97%