Preformulation studies for nortriptyline

Ledeți, Ionuț; Budiul, Mihaela; Matusz, Petru; Vlase, Gabriela; Circioban, Denisa; Dehelean, Cristina; Suta, Lenuta-Maria; Caunii, Angelica; Ledeţi, Adriana; Vlase, Titus; Murariu, Marius; Bolintineanu, Sorin

doi:10.1007/s10973-017-6269-5

Cited by 15 publications

(13 citation statements)

References 20 publications

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“…As observed, the porosity of the second sample is almost For the second sample we concluded that the DTA curves are very similar with the one presented in the specialty literature [8], for (NH 4 )MgPO 4…”

Section: Resultssupporting

confidence: 87%

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Considerations on Thermal Behaviour and Porosity of Renal Calculi in Bisphosphonate -Treated Postmenopausal Women

Tănăsescu¹,

Bardan²,

Ledeţi³

et al. 2017

Rev. Chim.

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A longitudinal, randomized, five year follow-up clinical and experimental study was conducted during May 1, 2011 - June 30, 2016. A number of 125 eligible postmenopausal women (BMD T-score spine (-2.8 � 0.5)); BMD at the femoral hip (-2.6 � 0.8), treated only with biphosphonates, were enrolled in the study. The patient�s age ranged between 60 and 65 years. All the women were stone formers, with more than five episodes of crystalluria in the last five years. Exclusion criteria: kidney chronic diseases, use of drugs known to affect bone metabolism and renal function, patients with multi-morbidities. The aim of our study was to assess the connection between postmenopausal osteoporosis and the risk of worsening calcium balance in urolithiasis, based on the complex thermogravimetric findings and porosity studies of renal stones eliminated by these patients. The study of renal-urinary concretions offers the possibility to amplify the specific effects of the thermal decomposition processes of substances, reflecting the sample�s global composition. The research of calculi porosity gives information about the dissolution possibilities of the renal-urinary concretions. In conclusion, in postmenopausal women, proper administration of bisphosphonate therapy must accompany the supplementary medication with calcium and vitamin D, always correlated to the metabolic status of the osteoporotic patient.

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Section: Resultssupporting

confidence: 87%

“…Thermogravimetric Analysis coupled to Mass Spectrometry, High-Temperature X-ray Diffraction, and Fourier Transform Infrared Spectroscopy are modern research tools, which highlight kidney stone composition and improve the knowledge of the bone mineral content, as noted in the studies they've published in recent years [3][4][5][6][7][8][9][10][11].…”

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confidence: 99%

Considerations on Thermal Behaviour and Porosity of Renal Calculi in Bisphosphonate -Treated Postmenopausal Women

Tănăsescu¹,

Bardan²,

Ledeţi³

et al. 2017

Rev. Chim.

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“…The summarization of thermoanalytical data is presented in Table 3. In previous papers, we also carried out diffractometric (XRPD) studies on binary mixtures kept under ambient conditions, when the corroboration of thermoanalytical data with the ones suggested by the FTIR spectroscopy were not concluding [23,25,26,35,39]. However, in the case of LTSS mixtures with selected excipients, no discrepancies were noticed between the selected instrumental techniques, as the incompatibilities suggested by the FTIR study were confirmed by the thermal analysis.…”

Section: Thermal Stability Investigationsmentioning

confidence: 99%

“…There were selected a number of solid excipients, having different properties and playing various roles into the final formulation. The following excipients were included: starch, anhydrous lactose, D-mannitol, D-sorbitol, gelatin, calcium lactate pentahydrate, magnesium stearate, methyl 2-hydroxyethyl cellulose (Tylose), colloidal SiO 2 (Aerosil) and talc, while, as instrumental techniques, UATR-FTIR spectroscopy and thermoanalytical tools were chosen, by a methodology previously reported in the literature [23][24][25][26][27][28][29][30][31].…”

Section: Concordet Et Al Reported In March 2017 a New Formulatimentioning

confidence: 99%

Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems—Instrumental Screening

et al. 2020

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The influence of excipients on the stability of sodium levothyroxine pentahydrate (LTSS) under ambient conditions and thermal stress was evaluated. Since LTSS is a synthetic hormone with a narrow therapeutic index, the interactions of LTSS with excipients can lead to a drastic diminution of therapeutic activity. Ten commonly used pharmaceutical excipients with different roles in solid formulations were chosen as components for binary mixtures containing LTSS, namely, starch, anhydrous lactose, D-mannitol, D-sorbitol, gelatin, calcium lactate pentahydrate, magnesium stearate, methyl 2-hydroxyethyl cellulose (Tylose), colloidal SiO2 (Aerosil) and talc. As investigational tools, universal attenuated total reflectance- Fourier transform infrared spectroscopy UATR-FTIR spectroscopy and thermal analysis were chosen and used as follows: UATR-FTIR spectra were drawn up for samples kept under ambient conditions, while thermoanalytical tools (TG/DTG/HF data) were chosen to evaluate the inducing of interactions during thermal stress. The corroboration of instrumental results led to the conclusion that LTSS is incompatible with lactose, mannitol and sorbitol, and these excipients should not be considered in the development of new generic solid formulations.

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“…Some studies were also carried out in the analysis of compounds used in the therapy of high cholesterol levels [13][14][15][16][17][18], by instrumental techniques, such as thermal analysis and spectroscopic techniques [19][20][21][22][23][24][25][26][27][28][29].…”

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The Protective Effect of HDL-Cholesterol in Patients with Essential Hypertension

Balint¹,

Iovănescu²,

Stanca³

et al. 2017

Rev. Chim.

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High blood pressure (HPB) is considered a major health problem affecting more than one billion people worldwide. Hypertension is the most common cardiovascular disorder that increases the risk of cardiovascular morbidity and mortality. HDL-cholesterol, considered to be an independent risk factor for cardiovascular events, presents pleiotropic effects that can influence arterial status and blood pressure. The aim of this study was to determine the correlation between HDL-cholesterol levels and blood pressure in normotensive and hypertensive patients (untreated and 1-month treated with statins) and to evaluate the arterial stiffness as a marker of endothelial dysfunction in these patients.

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Preformulation studies for nortriptyline

Cited by 15 publications

References 20 publications

Considerations on Thermal Behaviour and Porosity of Renal Calculi in Bisphosphonate -Treated Postmenopausal Women

Considerations on Thermal Behaviour and Porosity of Renal Calculi in Bisphosphonate -Treated Postmenopausal Women

Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems—Instrumental Screening

The Protective Effect of HDL-Cholesterol in Patients with Essential Hypertension

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