Preferential uptake of benzoporphyrin derivative by leukemic versus normal cells

Jamieson, Catriona; McDonald, William N.; Levy, Julia G.

doi:10.1016/0145-2126(90)90128-v

Cited by 46 publications

(14 citation statements)

References 6 publications

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“…Verteporfin selectively pools in choroidal haemangioma because of numerous vascular channels in the tumour and possibly by the uptake of the lining endothelial cells. 14,15 The mechanism of cell destruction in cases of choroidal haemangioma is presumed to be because of a combination of direct cytotoxicity and vascular occlusion. 8 We have followed the standard PDT protocol used for treatment of subretinal neovascular membranes with excellent results in choroidal haemangiomas.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Gupta

Singh

Rundle

et al. 2004

Eye

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Purpose To report efficacy of photodynamic therapy (PDT) in the treatment of three cases of juxtafoveal circumscribed choroidal haemangioma. Methods Data on three patients (two primary, and one failed TTT) treated with verteporfin, 6 mg/m 2 given as i.v. infusion over 10 min. Diode laser (690 nm) with an intensity of 600 mW/cm 2 for 83 s (50 mJ/cm 2 ) was applied 5 min after completion of infusion. Overlapping multiple spots (2500 lm) were applied to cover the entire surface of the tumour. The mean pretreatment tumour size was 7 mm (base) Â 2.2 (thickness) mm. Periodic follow-up with ophthalmoscopy, ultrasonography, and angiographic studies was performed. Results All three cases showed complete regression of the tumour with resolution of subretinal fluid, flattening of tumour, and absence of choroidal vasculature on ICG. The visual acuity either improved or remained stable in all three cases. The overlying retinal vessels remained unaffected. There were no ocular or systemic complications. Conclusions PDT is an effective treatment for management of juxtafoveal circumscribed choroidal haemangioma.

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Section: Discussionmentioning

confidence: 99%

Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Gupta

Singh

Rundle

et al. 2004

Eye

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“…Photoactivation of the chlorin‐type photosensitizer, benzoporphyrin derivative monoacid ring A (BPD‐MA), eradicates tumor cells through the generation of reactive oxygen intermediates [15]. BPD‐MA accumulates at higher levels in leukemic cells as compared to normal blood mononuclear cells [15, 16]. In vitro experiments have shown that photoactivation of BPD‐MA can selectively deplete leukemic cells while relatively sparing normal hematopoietic progenitor cells [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Bcl‐X_L prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA

Granville

Jiang

et al. 1998

FEBS Letters

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Photodynamic therapy (PDT) is a clinically effective cancer treatment. For human promyelocytic leukemia HL-60 cells, cleavage of pro-caspase-3 (CPP32/Yama/apopain) into its proteolytically active subunits rapidly follows the photodynamic treatment of these cells with cytotoxic levels of the photosensitizer benzoporphyrin derivative monoacid ring A and visible light. Cleavage of a recently identified cytosolic 45 kDa protein, DNA fragmentation factor (DFF), is required for endonuclease activation leading to DNA fragmentation. In the present study, DFF was rapidly processed following PDT. Overexpression of the anti-apoptotic Bcl-X v gene in HL-60 cells prevented PDTinduced caspase activation, DFF cleavage and DNA fragmentation. These results demonstrate for the first time an example of chemotherapeutic drug-induced activation of DFF and its regulation by Bcl-X v .z 1998 Federation of European Biochemical Societies.

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“…Autologous HSCT (Auto-HSCT) enjoys several advantages over allogeneic HSCT (Allo-HSCT): easy transplantation of grafts, without the restriction of age and the need for an HLA-matched donor, the absence of graft-versus-host disease (GVHD) and a small percentage of life-threatening infections. [1][2][3][4] It has been proven that auto-HSCT is a promising approach for leukemia therapy. However, it still has its limitation of high relapse rate, as compared with Allo-HSCT and the limitation is ascribed to the risk of reinfusing residual leukemic cells at the time of harvest.…”

Section: Introductionmentioning

confidence: 99%

Purging of murine erythroblastic leukemia by ZnPcS2P2-based-photodynamic therapy

Huang

Chen

et al. 2005

Bone Marrow Transplant

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A key point for successful transplantation of autologous hematopoietic stem cells in the treatment of leukemia is the purging technique, of which photodynamic therapy (PDT) proved effective and promising. The aim of this study was to evaluate the purging effect of a novel amphipathic photosensitizer, di-sulfo-di-phthalimidomethyl phthalolcyanine zinc (ZnPcS 2 P 2 )-based PDT (ZnPcS 2 P 2 -PDT) on murine erythroblastic leukemic EL9611 cells. Bone marrow cells (BMC), harvested from normal BALB/c mice, were contaminated with variable EL9611 cells. Cell suspensions were incubated with 4 lg/ml ZnPcS 2 P 2 for 5 h and then exposed to 2.1 J/cm 2 irradiation by a semiconductor laser 670 nm. Lethally irradiated recipient BALB/c mice (7 Gy) received syngeneic bone marrow transplantation with purged or nonpurged cell mixtures of 10 7 BMC contaminated with variable numbers (10 2 -10 5 ) of EL9611 cells. All of the irradiated controls died due to sepsis. All of the mice injected with nonpurged cell mixtures developed leukemia and died, whereas the mice transplanted with ZnPcS 2 P 2 -PDT-treated mixtures had a longer survival time, and the fewer leukemic cells there were in the cell mixtures, the higher the leukemia-free survival rate. We conclude that ZnPcS 2 P 2 -PDT could purge leukemic cells from bone marrow autografts but could retain sufficient progenitor cells for the hematopoietic activity.

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Preferential uptake of benzoporphyrin derivative by leukemic versus normal cells

Cited by 46 publications

References 6 publications

Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Overexpression of Bcl‐X_L prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA

Purging of murine erythroblastic leukemia by ZnPcS2P2-based-photodynamic therapy

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Preferential uptake of benzoporphyrin derivative by leukemic versus normal cells

Cited by 46 publications

References 6 publications

Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Efficacy of photodynamic therapy in circumscribed choroidal haemangioma

Overexpression of Bcl‐XL prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA

Purging of murine erythroblastic leukemia by ZnPcS2P2-based-photodynamic therapy

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Overexpression of Bcl‐X_L prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA