Preferential recruitment of bone marrow-derived cells to rat palatal wounds but not to skin wounds

Verstappen, J.; Rheden, René E M van; Katsaros, Christos; Torensma, Ruurd; Hoff, Johannes W. Von den

doi:10.1016/j.archoralbio.2011.08.005

Cited by 9 publications

(9 citation statements)

References 29 publications

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“…In a rat model, it was shown that bone marrow‐derived mesenchymal stem cells (labeled with green fluorescent protein) invaded healing wounds and differentiated into myofibroblasts . Moreover, these stem cells were preferentially recruited to oral mucosal wounds, rather than to skin wounds , perhaps explaining, in part, the larger healing potential of oral mucosa.…”

Section: Growth Factor‐mediated Control Of Fibroblast Function Duringmentioning

confidence: 99%

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair

Chiquet¹,

Katsaros²,

Kletsas³

2015

Periodontology 2000

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Fibroblasts are cells of mesenchymal origin. They are responsible for the production of most extracellular matrix in connective tissues and are essential for wound healing and repair. In recent years, it has become clear that fibroblasts from different tissues have various distinct traits. Moreover, wounds in the oral cavity heal under very special environmental conditions compared with skin wounds. Here, we reviewed the current literature on the various interconnected functions of gingival and mucoperiosteal fibroblasts during the repair of oral wounds. The MEDLINE database was searched with the following terms: (gingival OR mucoperiosteal) AND fibroblast AND (wound healing OR repair). The data gathered were used to compare oral fibroblasts with fibroblasts from other tissues in terms of their regulation and function during wound healing. Specifically, we sought answers to the following questions: (i) what is the role of oral fibroblasts in the inflammatory response in acute wounds; (ii) how do growth factors control the function of oral fibroblasts during wound healing; (iii) how do oral fibroblasts produce, remodel and interact with extracellular matrix in healing wounds; (iv) how do oral fibroblasts respond to mechanical stress; and (v) how does aging affect the fetal‐like responses and functions of oral fibroblasts? The current state of research indicates that oral fibroblasts possess unique characteristics and tightly controlled specific functions in wound healing and repair. This information is essential for developing new strategies to control the intraoral wound‐healing processes of the individual patient.

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Section: Growth Factor‐mediated Control Of Fibroblast Function Duringmentioning

confidence: 99%

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair

Chiquet¹,

Katsaros²,

Kletsas³

2015

Periodontology 2000

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“…, Verstappen et al. ) have been found effective in preventing such complications, an ideal support could not be specified for this purpose. Further, undesired side effects such as delayed wound healing/foreign body reaction (Petersen et al.…”

mentioning

confidence: 99%

“…However, paresthesia, herpetic lesion, mucocele, arteriovenous shunt, excessive bleeding (BLE) and severe post-operative pain have been reported following FGG procedure (Brasher et al 1975, Wang et al 2001. Although haemostatics (Rossmann & Rees 1999, Kim et al 2012, mechanical barriers (Farnoush 1978), bioactive materials (Carnio & Hallmon 2005, Yen et al 2007, Shanmugam et al 2010, Ayvazyan et al 2011, Hammad et al 2011, Thoma et al 2012, antibacterial and antiseptic agents (Kozlovsky et al 2007, Hammad et al 2011, Patel et al 2012, herbal products (Hammad et al 2011, Verstappen et al 2012) have been found effective in preventing such complications, an ideal support could not be specified for this purpose. Further, undesired side effects such as delayed wound healing/foreign body reaction (Petersen et al 1984, Finn et al 1992, Matthew et al 1993) have been notified.…”

mentioning

confidence: 99%

Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery

Keçeli

Aylıkçı

Köseoğlu

et al. 2015

J Clinic Periodontology

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“…In addition to maintaining steady-state hemopoiesis in healthy subjects, bone marrow supports emergency, or stress, hemopoiesis, i.e ., the lineage-selective expansion of hemopoietic cells to meet the exceptional demands of hemorrhage[ 4 , 5 ] or infection[ 6 - 9 ]. The cumulative evidence, however, highlights a third important function of bone marrow in whole-body homeostasis, namely its role in repair following injury of distant sites, especially the skin[ 10 - 13 ], Central Nervous System[ 14 - 22 ], eye[ 23 - 26 ], heart[ 27 - 32 ], lungs[ 33 , 34 ], liver[ 35 - 37 ], gastric mucosa[ 38 , 39 ], chronic wounds associated with diabetes and vasculopathy[ 40 - 46 ], oral mucosa and teeth[ 47 - 51 ], bone and cartilage[ 52 - 54 ] and skeletal muscle[ 55 - 59 ] among other structures.…”

Section: Need To Explore the Emerging Roles Of Bone Marrow In Responsmentioning

confidence: 99%

“…Most injuries to the skin and to the oral mucosa in subjects without an underlying disease heal within a short time, which testifies to the effectiveness of innate immunity as well as repair mechanisms at both locations, but tells us little about the relationship between immunity and repair at either site. Does the bone marrow response discriminate between surgical injuries inflicted upon the skin and the oral mucosa, to give a concrete example[ 47 ]? Simple as the question may seem, it has no clear-cut answer at this time, although it certainly deserves attention.…”

Section: Cecal Ligation and Puncture As A Surgical Model Amenable To mentioning

confidence: 99%

Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy

Xavier−Elsas

Ferreira

Gaspar−Elsas

2017

WJEM

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Bone marrow, the vital organ which maintains lifelong hemopoiesis, currently receives considerable attention, as a source of multiple cell types which may play important roles in repair at distant sites. This emerging function, distinct from, but closely related to, bone marrow roles in innate immunity and inflammation, has been characterized through a number of strategies. However, the use of surgical models in this endeavour has hitherto been limited. Surgical strategies allow the experimenter to predetermine the site, timing, severity and invasiveness of injury; to add or remove aggravating factors (such as infection and defects in immunity) in controlled ways; and to manipulate the context of repair, including reconstitution with selected immune cell subpopulations. This endows surgical models overall with great potential for exploring bone marrow responses to injury, inflammation and infection, and its roles in repair and regeneration. We review three different murine surgical models, which variously combine trauma with infection, antigenic stimulation, or immune reconstitution, thereby illuminating different aspects of the bone marrow response to systemic injury in sepsis, trauma and allergy. They are: (1) cecal ligation and puncture, a versatile model of polymicrobial sepsis; (2) egg white implant, an intriguing model of eosinophilia induced by a combination of trauma and sensitization to insoluble allergen; and (3) ectopic lung tissue transplantation, which allows us to dissect afferent and efferent mechanisms leading to accumulation of hemopoietic cells in the lungs. These models highlight the gain in analytical power provided by the association of surgical and immunological strategies.

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Preferential recruitment of bone marrow-derived cells to rat palatal wounds but not to skin wounds

Abstract: The results indicate that bone marrow-derived cells are preferentially recruited to wounded oral mucosa but not to wounded skin. This might be related to the larger healing potential of oral mucosa.

Cited by 9 publications

References 29 publications

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair

Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery

Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy

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