Preferential production of the IL‐12(p40)/IL‐23(p19) heterodimer by dendritic cells from human newborns

Eijnden, Serge Vanden; Goriely, Stanislas; Wit, Dominique De; Goldman, Michel; Willems, Fabienne

doi:10.1002/eji.200535467

Cited by 90 publications

(70 citation statements)

References 14 publications

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“…Notably, adult humans lacking production of IL-17 appear specifically vulnerable to neonatal pathogens such as Candida and Staphylococcus aureus [54]. To help promote systemic Th17 responses in the full-term neonate, neonatal antigen-presenting cells produce high levels of IL-1β, IL-6, but also high amounts of IL-23 [55]. By contrast, monocytes and dendritic cells from preterm neonates below 29 weeks of gestation produce low amounts of IL-1β and IL-23 [9,15].…”

Section: Box 3 Natural Microbial Colonization Of the Newborn Infantmentioning

confidence: 99%

An Immunological Perspective on Neonatal Sepsis

Kan

Razzaghian

Lavoie

2016

Trends in Molecular Medicine

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Despite concerted international efforts, mortality from neonatal infections remains unacceptably high in some areas of the world, particularly for premature infants. Recent developments in flow cytometry and next-generation sequencing technologies have led to major discoveries over the past few years, providing a more integrated understanding of the developing human immune system in the context of its microbial environment. We review these recent findings, focusing on how in human newborns incomplete maturation of the immune system before a full term of gestation impacts on their vulnerability to infection. We also discuss some of the clinical implications of this research in guiding the design of more-accurate age-adapted diagnostic and preventive strategies for neonatal sepsis.

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Section: Box 3 Natural Microbial Colonization Of the Newborn Infantmentioning

confidence: 99%

An Immunological Perspective on Neonatal Sepsis

Kan

Razzaghian

Lavoie

2016

Trends in Molecular Medicine

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“…1). Once activated, DC also release cytokines such as IL-6, IL-18, IL-23, IL-32 and IL-33 that activate pathogenic T lymphocytes in the wall of inflamed arteries [63]. The production of pro-inflammatory cytokines such as IL-6, IL-32 and IL-33 appears to closely correlate with the expression and severity of systemic symptoms [63] (Fig.…”

Section: Dendritic Cells Activation In Gcamentioning

confidence: 99%

New insights into the pathogenesis of giant cell arteritis

Ciccia

Rizzo

Ferrante

et al. 2017

Autoimmunity Reviews

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“…High IL-6 and IL-23 reactivity has been described in newborns [36,37] suggesting that they might have a good capacity to mount an IL-17 response. However, we found SEB stimulated IL-17 levels to be very low or undetectable in cord blood cultures, while mothers had robust IL-17 responses.…”

Section: Cd25mentioning

confidence: 99%

The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth

et al. 2010

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Placental malaria (PM), a frequent infection of pregnancy, provides an ideal opportunity to investigate the impact on immune development of exposure of the foetal immune system to foreign Ag. We investigated the effect of PM on the regulatory phenotype and function of cord blood cells from healthy Gambian newborns and peripheral blood cells from their mothers, and analyzed for effects on the balance between regulatory and effector responses. Using the gold standard for classifying PM we further distinguished between resolved infection and acute or chronic PM active at the time of delivery. We show that exposure to malarial Ag in utero results in the expansion of malaria-specific FOXP31 Treg and more generalized FOXP3 1 CD4 1 Treg in chronic and resolved PM, alongside increased Th1 pro-inflammatory responses (IFN-c, TNF-a, IFN-c:IL-10) in resolved PM infection only. These observations demonstrate a clear effect of exposure to malarial Ag in foetal life on the immune environment at birth, with a regulatory response dominating in the newborns with ongoing chronic PM, while those with resolved infection produce both regulatory and inflammatory responses. The findings might explain some of the adverse effects on the health of babies born to women with PM.

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Preferential production of the IL‐12(p40)/IL‐23(p19) heterodimer by dendritic cells from human newborns

Cited by 90 publications

References 14 publications

An Immunological Perspective on Neonatal Sepsis

An Immunological Perspective on Neonatal Sepsis

New insights into the pathogenesis of giant cell arteritis

The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth

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