Preferential occupancy of metal ions in the hydroxyapatite solid solutions synthesized by hydrothermal method

Zhu, Kongjun; Yanagisawa, Kazumichi; Shimanouchi, Rie; Onda, Ayumu; Kajiyoshi, Koji

doi:10.1016/j.jeurceramsoc.2005.07.019

Cited by 109 publications

(45 citation statements)

References 16 publications

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“…Strontium can replace calcium in the HA structure in the whole range of composition, inducing a linear variation of the lattice constants. 21,22 This article is aimed to evaluate the influence of strontium substitution to calcium into hydroxyapatite structure on the in vitro response of bone cells. For this purpose we have carried out an in vitro study on cultures of osteoclast and osteoblast grown on HA nanocrystals synthesized at different extent of strontium substitution for calcium.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Sr‐doped hydroxyapatite nanocrystals with osteoclast and osteoblast‐like cells

Capuccini

Torricelli

Boanini

et al. 2008

J Biomedical Materials Res

189

130

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This article reports the effect of strontium incorporation into hydroxyapatite nanocrystals on bone cells response. Hydroxyapatite nanocrystals were synthesized at strontium contents of 0, 1, 3, 7 atom %. Strontium incorporation for calcium is confirmed by the linear increase of the unit cell parameters of hydroxyapatite, in agreement with the different ionic radii of the two ions. Moreover, strontium substitution slightly affects hydroxyapatite structural order and the shape of the nanocrystals. Osteoblast-like MG63 cells cultured on the nanocrystals display good proliferation and increased values of the differentiation parameters. In particular, when cultured on samples with Sr concentration in the range 3-7 atom %, osteoblasts display increased values of ALP activity, collagen type I, and osteocalcin production. Moreover, the osteoclast number on all the Sr-doped samples is significantly smaller than on hydroxyapatite, and it decreases on increasing strontium content. The data indicate that strontium stimulates osteoblast activity and exerts its inhibitory effect on osteoclast proliferation even when incorporated into hydroxyapatite.

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Section: Introductionmentioning

confidence: 99%

Interaction of Sr‐doped hydroxyapatite nanocrystals with osteoclast and osteoblast‐like cells

Capuccini

Torricelli

Boanini

et al. 2008

J Biomedical Materials Res

189

130

View full text Add to dashboard Cite

show abstract

“…Joni metala sa većim prečnikom i većom elektronegativnošću prvenstveno supstituišu jone metala u položaju M2, dok se joni metala sa manjim prečnikom i manjom elektronegativnošću supstituišu u položaju M1 [28]. Katjoni Ba 2+ , Pb 2+ i Sr 2+ , koji su veći od Ca 2+ jona smeštaju se u položaje M2 [29].…”

Section: Modifikacija Hap-a Katjonimaunclassified

Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine

Milošević¹,

Ignjatović²,

Uskokovic³

2017

Tehnika

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“…Heavy metal cations can easily substitute for Ca 2+ in the hydroxylapatite structure and form zinc-calcium hydroxylapatite (Zn-Ca-HA), lead-calcium hydroxylapatite2 Journal of Chemistry understand mineral evolution and natural phenomenon or to optimize the industrial processes concerning apatite [5,19,20].…”

Section: Introductionmentioning

confidence: 99%

Characterization, Dissolution, and Solubility of Zn-Substituted Hydroxylapatites [(Zn_xCa_1−x)₅(PO₄)₃OH] at 25°C

Zhao

Zhu

et al. 2017

Journal of Chemistry

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A series of Zn-substituted hydroxylapatites [(Zn x Ca 1−x ) 5 (PO 4 ) 3 OH, Zn-Ca-HA] with the Zn/(Zn + Ca) molar ratio ( Zn ) of 0∼0.16 was prepared and characterized, and then the dissolution of the synthesized solids in aqueous solution was investigated by batch experiment. The results indicated that the aqueous zinc, calcium, and phosphate concentrations greatly depended on the Zn/(Zn + Ca) molar ratio of the Zn-Ca-HA solids ( Zn ). For the Zn-Ca-HA dissolution at 25 ∘ C with an initial pH of 2.00, the final solution pH increased, while the final solution calcium and phosphate concentrations decreased with the increasing Zn . The final solution zinc concentrations increased with the increasing Zn when Zn ≤ 0.08 and decreased with the increasing Zn when Zn = 0.08∼0.16. The mean sp values for (Zn x Ca 1−x ) 5 (PO 4 ) 3 OH at 25 ∘ C decreased from 10 −57.75 to 10 −58.59 with the increasing Zn from 0.00 to 0.08 and then increased from 10 -58.59 to 10 -56.63 with the increasing Zn from 0.08 to 0.16. This tendency was consistent with the dependency of the lattice parameter on Zn . The corresponding free energies of formation (Δ ) increased lineally from −6310.45 kJ/mol to −5979.39 kJ/mol with the increasing Zn from 0.00 to 0.16.

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Preferential occupancy of metal ions in the hydroxyapatite solid solutions synthesized by hydrothermal method

Cited by 109 publications

References 16 publications

Interaction of Sr‐doped hydroxyapatite nanocrystals with osteoclast and osteoblast‐like cells

Interaction of Sr‐doped hydroxyapatite nanocrystals with osteoclast and osteoblast‐like cells

Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine

Characterization, Dissolution, and Solubility of Zn-Substituted Hydroxylapatites [(Zn_xCa_1−x)₅(PO₄)₃OH] at 25°C

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Preferential occupancy of metal ions in the hydroxyapatite solid solutions synthesized by hydrothermal method

Cited by 109 publications

References 16 publications

Interaction of Sr‐doped hydroxyapatite nanocrystals with osteoclast and osteoblast‐like cells

Interaction of Sr‐doped hydroxyapatite nanocrystals with osteoclast and osteoblast‐like cells

Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine

Characterization, Dissolution, and Solubility of Zn-Substituted Hydroxylapatites [(ZnxCa1−x)5(PO4)3OH] at 25°C

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Product

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Characterization, Dissolution, and Solubility of Zn-Substituted Hydroxylapatites [(Zn_xCa_1−x)₅(PO₄)₃OH] at 25°C