Preferences and utilities for the symptoms of moderate to severe allergic asthma

Lloyd, Andrew; Doyle, Scott; Dewilde, Sarah; Turk, Florian

doi:10.1007/s10198-007-0075-0

Cited by 16 publications

(15 citation statements)

References 18 publications

(18 reference statements)

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“…While respondents placed the most value on avoidance of daytime symptoms, they also reported a higher WTP to avoid waking up in the night, and not requiring an inhaler compared to waking up with symptoms and requiring an inhaler. The authors acknowledged that this may not be intuitively correct, and postulated that the result may have been due to the respondents’ not fully understanding the nature of inhaler use and its link with the severity of symptoms 43. McTaggart-Cowan et al reported that patients with asthma preferred a treatment regimen that resulted in more symptom-free days but were willing to forego some of this benefit in exchange for a more convenient regimen or a reduction in the frequency of adverse events 44…”

Section: Resultsmentioning

confidence: 99%

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Patient preferences in severe COPD and asthma: a comprehensive literature review

Bereza

Nielsen²,

Valgardsson³

et al. 2015

COPD

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BackgroundManagement of chronic incurable diseases such as chronic obstructive pulmonary disease (COPD) and asthma is difficult. Incorporation of patient preferences is widely encouraged.PurposeTo summarize original research articles determining patient preference in moderate-to-severe disease.MethodsAcceptable articles consisted of original research determining preferences for any aspect of care in patients with COPD/asthma. The target population included those with severe disease; however, articles were accepted if they separated outcomes by severity or if the majority had at least moderate-to-severe disease. We also accepted simulation research based on scenarios describing situations involving moderate-to-severe disease that elicited preferences. Two reviewers searched Medline and Embase for articles published from the date of inception of the databases until the end of November 2014, with differences resolved through consensus discussion. Data were tabulated and analyzed descriptively.ResultsAbout 478 articles identified, 448 were rejected and 30 analyzed. There were 25 on COPD and five on asthma. Themes identified as most important in COPD were symptom relief (dyspnea/breathlessness), a positive patient–physician relationship, quality-of-life impairments, and information availability. Patients strongly preferred sponsors’ inhalers. At end-of-life, 69% preferred receiving CPR, 70% wanted noninvasive, and 58% invasive mechanical intervention. While patients with asthma preferred treatments that increased symptom-free days, they were willing to trade days without symptoms for a reduction in adverse events and greater convenience. Asthma patients were willing to pay for waking up once and not needing their inhaler over waking up once overnight and needing their inhaler.ConclusionFew studies have examined patient preference in these diseases. More research is needed to fill in knowledge gaps.

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Section: Resultsmentioning

confidence: 99%

“…However, each study had limitations that may affect the rigor of the results. In the Lloyd et al43 study, it was unclear whether the sample size was sufficient to capture reliable estimates. Furthermore, a high proportion of participants failed the consistency check in the survey, rendering the sample even smaller.…”

Section: Discussionmentioning

confidence: 99%

Patient preferences in severe COPD and asthma: a comprehensive literature review

Bereza

Nielsen²,

Valgardsson³

et al. 2015

COPD

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“…VAS ratings show a much larger difference between the best and worst health state. 72 The authors suggest that VAS data should not be used to inform cost-effectiveness analyses. 72 The SG data should be considered the primary source of utility data.…”

Section: Lloyd Et Al Observed That Standard Gamble (Sg) and Visual Anmentioning

confidence: 98%

“…72 The authors suggest that VAS data should not be used to inform cost-effectiveness analyses. 72 The SG data should be considered the primary source of utility data. 72 Szende and colleagues observed that when the EQ-5D was used to derive values for asthma health states, a high proportion of patients reported a value of '1'.…”

Section: Lloyd Et Al Observed That Standard Gamble (Sg) and Visual Anmentioning

confidence: 98%

“…72 The SG data should be considered the primary source of utility data. 72 Szende and colleagues observed that when the EQ-5D was used to derive values for asthma health states, a high proportion of patients reported a value of '1'. 70 This finding suggests that the EQ-5D was unable to differentiate between patients whose health is close to the best possible health status.…”

Section: Lloyd Et Al Observed That Standard Gamble (Sg) and Visual Anmentioning

confidence: 99%

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Utilities for asthma and COPD according to category of severity: a comprehensive literature review

Einarson

Bereza

Nielsen³

et al. 2015

Journal of Medical Economics

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Eliciting preferences to the EQ-5D-5L health states: discrete choice experiment or multiprofile case of best–worst scaling?

et al. 2013

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Choice-based methods have been used widely in assessing healthcare programs. This study compared the binary discrete choice experiment (DCE) and the multiprofile case of best-worst scaling (BWS) in eliciting preferences for the EQ-5D-5L. Forty-eight EQ-5D-5L health states were selected using a Bayesian efficient design and grouped into 24 pairs for the DCE tasks and 8 sets for the BWS tasks (each set has three health states). A total of 100 participants completed 12 pairs and 8 sets in a random order. A probit regression model and ranked order logistic regression model were used to estimate the latent utilities from the DCE and BWS, respectively. Both tasks were well understood by the majority of participants. The DCE tasks were relatively easier and took a shorter time to complete. The intraclass correlation coefficient (ICC) of the DCE was higher than that of the BWS. The variances associated with the latent utilities estimated from the DCE were larger than those from the BWS. The DCE is more feasible and reliable than the BWS in valuing the EQ-5D-5L. Future studies could focus on comparing the consistency and accuracy of these techniques in predicting the health utilities of the EQ-5D-5L.

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Preferences and utilities for the symptoms of moderate to severe allergic asthma

Cited by 16 publications

References 18 publications

Patient preferences in severe COPD and asthma: a comprehensive literature review

Patient preferences in severe COPD and asthma: a comprehensive literature review

Utilities for asthma and COPD according to category of severity: a comprehensive literature review

Eliciting preferences to the EQ-5D-5L health states: discrete choice experiment or multiprofile case of best–worst scaling?

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