Preference of di-n-butyltinIV compounds to build O⋯Sn bonds in fused rings with five-six members

A Bis(di‐n‐butyltin)–Quinone Derivative as a Simultaneous Chemo‐ and Bioactive Corrosion Inhibitor

“…This Sn···O intermolecular interaction www.eurjic.org has also been observed for other pentacoordinate di-n-butyltin complexes derived from ONO ligands. [12] The polymeric fragments are organized in layers, between which the nBu moieties are located (Figure 2). The benzoquinone ligand 1 and the bis(di-n-butyltin)-quinone derivative 2 were screened in vitro for their antibacterial activity against three types of aerobic bacteria, Bacillus subtilis (Gram-positive, strain ATCC 6633), Escherichia coli (Gram-negative, strain DH5) and Pseudomona fluorescens (Gram-negative, strain BH3), and two types of anaerobic species (sulfate-reducing bacteria, SRB), Desulfovibrio vulgaris (strain DSM 644) and a bacteria con-sortium (strain 82) isolated from a hydrocarbon pipeline of the Mexican oil industry (PEMEX).…”

Synthesis and characterization of di-phenyl-tinIV-salicyliden-ortho-aminophenols: Analysis of in vitro antitumor/antioxidant activities and molecular structures

“…The obtaining of 4a-4g compounds in pure crystalline form was accomplished after slow evaporation of the reaction solvent reaching the precipitation point. The present attempt is a preparation procedure involving only polar protic solvent instead of benzene/ethanol or toluene/butanol mixtures or Schiff base salt formation [34,46,47,64]. The change in the reaction media led cleaner substances without needs of neither further recrystallization nor purification and the advantage of swiftly providing crystals for X-ray diffraction.…”

“…The unambiguous assignment, defining of coupling system types as well as the determination of one bond and long range heteronuclear coupling constants, n J( 119/117 Sn-1 H), m J( 119/117 Sn-13 C) where n = 2-3 and m = 1-4, were systematically determined for 4 type compounds [34,46,47]. For 4a-4g the 1 H and 13 C signals for the di-phenyl-tin IV fragment are isochronous due to the presence of a mirror plane along the ortho-aminophenol and salicyliden moieties.…”

“…All of them are important hypotheses from basic and applied research viewpoints. In this line we set together molecular motifs which resulted important for biological studies and close to our research lines: (i) Schiff bases and their tin and organotin derivatives [38][39][40][41][42][43] have been tested in vitro in antitumor assays showing moderate-good activity; (ii) di-n-butyl-tin IV compounds with ortho-aminophenols presented better antitumor activities and less damage in normal cells when compared against cis-platin [44]; (iii) the statements that di-phenyl-tin IV derivatives could result pretty less toxic than other di-organo-tin IV derivatives due to their interaction towards the cell membrane [10][11][12]37]; (iv) the advantage that in our group there have been prepared three different series of monomeric di-phenyl-tin IV derivatives [34,45,46] with Schiff bases (instead of mono-, di-or polymeric forms when di-n-butyl-tin IV fragments are employed) [34,46,47]; (v) it has been reported one di-phenyl-tin IV compound possessing this set of molecular variables [48], 3 X-ray structures were found in the CCDC, two were reported by our work group [49], and none of them has been biologically tested. Therefore, it merits studying a family of compounds based in this lead di-phenyl-tin IV derivative with single chemical modifications now with the premise of evaluating not one but two biological activities to determine specificity.…”

“…Concomitantly, it has been proposed that the cell oxidative stress has been directly related towards cancer disease [50][51][52] thus counterpart activities are going to be measured. To prepare the desired tin compounds we applied a one pot reaction of salicylaldehyde, ortho-aminophenols, and di-phenyl-tin IV oxide giving seven di-phenyl-tin IV compounds in a similar fashion as that previously reported [34,46,47]. The molecular variations through different substitutions were centered in the ortho-aminophenol moiety to track the resulting responses in biological activities and hence define relationships.…”