Preference for the term pilomatrical carcinoma with melanocytic hyperplasia

Perez, Caroline; Debbaneh, Maya

doi:10.1111/cup.12941

Cited by 4 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is a key factor in distinguishing them from pigmented variants, which show pigmentation but do not typically show melanocytic hyperplasia (confirmed by immunohistochemistry for melanocytic markers). 22 In our practice, melanocytic differentiation is rare in typical cases of pilomatricoma. The lesions showed granulomatous inflammation and two of them showed a cystic component, features more often seen in pilomatricoma.…”

Section: Discussionmentioning

confidence: 97%

“…Overall, we consider that this terminology reflects the overlapping histopathological and molecular features with pilomatricoma and recognizes that they are likely to be variants of pilomatricoma associated with melanocytic hyperplasia. 22 The specimen for the third case was scanty and the basaloid cells lacked nuclear staining for β-catenin. This may have been because of specimen sampling.…”

Section: Discussionmentioning

confidence: 99%

“…We discuss the histopathological, immunohistochemical, and molecular features, and highlight the features of malignancy. These tumors are closely related to pilomatricoma and so we propose that the terminology suggested by Perez et al for malignant melanocytic matricoma (pilomatrical carcinoma with melanocytic hyperplasia) also be adapted for benign cases (pilomatricoma with melanocytic hyperplasia) 22 . Our center deals with large numbers of referrals and the three cases presented here had some differences from pilomatricoma and some features overlapping with pilomatricoma.…”

Section: Introductionmentioning

confidence: 84%

“…The presence of melanocytic hyperplasia is a critical factor, as pigmented pilomatrical carcinoma shows melanin pigmentation but not a distinct component of melanocytic hyperplasia. 22 Similar terminology could be applied to benign lesions. We propose that the term "pilomatricoma with melanocytic hyperplasia" best describes the three cases we have presented here.…”

Section: Discussionmentioning

confidence: 99%

“…23 The lesion diagnosed by Perez et al as pilomatrical carcinoma with melanocytic hyperplasia is a further example of a malignant case, because of the overlapping histopathological features. 22 Nielson and Vineck recommended that all melanocytic matricomas be treated with complete excision with clear margins and followed up. 23 The three cases reported here did not show any of the adverse features listed above and the patients are all well at the time of writing.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Melanocytic matricoma: A report of three cases, review of the literature, and suggestion of a new terminology

Ferrier

Husain

2022

J Cutan Pathol

View full text Add to dashboard Cite

Melanocytic matricoma is a rare, biphasic adnexal tumor. It typically presents as a pigmented papule on the sun‐damaged skin of elderly patients. Histopathology shows a dermal nodule composed of basaloid cells, ghost cells, and deeply pigmented dendritic melanocytes. The basaloid cells are usually positive for β‐catenin and these tumors show overlapping histopathological and molecular features with pilomatricoma. Here, we review the literature on melanocytic matricoma and present three new cases. We suggest different terminology to reflect the overlapping features with pilomatricoma that recognizes that melanocytic matricoma is likely to be a variant of pilomatricoma associated with melanocytic hyperplasia. Although melanocytic matricoma is usually considered benign, malignant transformation has been reported. This highlights the need for increased awareness of this entity.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Melanocytic matricoma: A report of three cases, review of the literature, and suggestion of a new terminology

Ferrier

Husain

2022

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Nogales-Moro

Pinilla-Pagnon

Silvestre-Torner

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Melanocytic matricoma with atypical features is a rare, biphasic adnexal neoplasm displaying hair matrix differentiation, with only 3 reported cases worldwide. Generally, the lesion comprised a solid matrical and supramatrical cell proliferation, admixed with intermediate cell aggregates with sparse anucleated "shadow cells" and a prominent pigmented melanocytic hyperplasia. We report the case of a 78-year-old man with a slow-growing crusted lesion on the frontal left scalp, which in a matter of 1-2 months became a 0.6 cm well-defined, black purplish exophytic nodule. Histopathologically, the lesion presented a well-circumscribed border with a nodular dermal growth pattern, presenting different architectural features varying from benign pilomatricoma-like changes to atypical features such as moderate-to-high nuclear pleomorphism in both basaloid (matrical/supramatrical) and epidermal (keratinous) components. Strong nuclear and cytoplasmic positivity for b-catenin was observed in matrical cells, whereas prominent cytoplasmic membrane positivity for Melan-A in dendritic melanocytes. Owing to the evidence of atypical cytological features, we propose the "atypical/borderline" category of melanocytic matricoma as part of a possible spectrum among matrical neoplasms. Pathologists should be aware of any atypical histopathological features while reporting cases due to their potential malignant transformation.

show abstract

Atypical Melanocytic Matricoma: A Case Report with Molecular Studies

Feoli

Stieber

Bormans

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Melanocytic matricoma is a rare benign pilar tumor characterized by matrical differentiation and interspersed dendritic melanocytes. It may show cellular atypia and brisk mitotic activity. Histological characterization of some lesions may be difficult. In addition, because the reported cases are few and have limited follow-up, there is insufficient experience to define outcome-based criteria for malignancy. Some cases of melanocytic matricoma with more prominent atypia have been reported as malignant, but their clinical behavior is uncertain. We present a melanocytic matricoma with interspersed benign dendritic melanocytes, but moderate basaloid atypia, focally brisk mitotic activity, and atypical mitoses. Despite the apparently good delimitation of this tumor, higher magnification revealed a slightly irregular border. However, overt malignant features such as necrosis, frank asymmetry, deep infiltration, and ulceration were not present. This tumor showed a complex aberrant genomic profile with multiple whole chromosomes or chromosomal arms, losses, and duplications. The tumor mutational burden was high. A loss-of-function alteration in CDKN2A and a loss-of-function mutation in TP53 were also present. This unexpected molecular profile contrasts with the relatively bland histology of the tumor and is in line with the difficulties in microscopic differential diagnosis between melanocytic matricoma and an indolent malignant pilomatrical tumor. We suggest that molecular studies and longer follow-up periods may help to further understand and more precisely categorize borderline pilomatrical tumors with melanocytic hyperplasia.

show abstract

Preference for the term pilomatrical carcinoma with melanocytic hyperplasia

Cited by 4 publications

References 10 publications

Melanocytic matricoma: A report of three cases, review of the literature, and suggestion of a new terminology

Melanocytic matricoma: A report of three cases, review of the literature, and suggestion of a new terminology

Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Atypical Melanocytic Matricoma: A Case Report with Molecular Studies

Contact Info

Product

Resources

About