Preface of the Special Issue “Pharmaceutical Crystals”

Abstract

Dear Colleagues, [...]

Is it possible to predict the stability of a crystal structure under the influence of pressure? Quantum chemical study of ibuprofen crystals

“…The crystalline state is one of the most used forms of active pharmaceutical ingredients (APIs) in the industry. 1 This can be explained by the higher thermodynamic stability of solids as compared to others and their manufacturability. 2–5 Unfortunately, solids can undergo polymorphic transformations at any stage of production or storage under the influence of temperature, pressure, impurities, contamination or simply with time.…”