Preface: Cellular actions of biogenic amines

Blenau, Wolfgang

doi:10.1002/arch.20072

Cited by 12 publications

(4 citation statements)

References 32 publications

(25 reference statements)

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“…Serotonin is a biogenic amine, an important neuroactive molecule within the CNS of several insect species. Serotonin, dopamine, histamine, octopamine, and tyramine are amines which have been extensively studied in Drosophila (reviewed in [ 1 , 79 , 80 ]. Each one of the five aminergic neuronal systems—including the serotonergic system—exhibits a stereotypic pattern of a small number of neurons that are widely distributed in the larval and adult CNS [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae

et al. 2017

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The biogenic amine serotonin (5-HT) is an important neuroactive molecule in the central nervous system of the majority of animal phyla. 5-HT binds to specific G protein-coupled and ligand-gated ion receptors to regulate particular aspects of animal behavior. In Drosophila, as in many other insects this includes the regulation of locomotion and feeding. Due to its genetic amenability and neuronal simplicity the Drosophila larva has turned into a useful model for studying the anatomical and molecular basis of chemosensory behaviors. This is particularly true for the olfactory system, which is mostly described down to the synaptic level over the first three orders of neuronal information processing. Here we focus on the 5-HT receptor system of the Drosophila larva. In a bipartite approach consisting of anatomical and behavioral experiments we describe the distribution and the implications of individual 5-HT receptors on naïve and acquired chemosensory behaviors. Our data suggest that 5-HT1A, 5-HT1B, and 5-HT7 are dispensable for larval naïve olfactory and gustatory choice behaviors as well as for appetitive and aversive associative olfactory learning and memory. In contrast, we show that 5-HT/5-HT2A signaling throughout development, but not as an acute neuronal function, affects associative olfactory learning and memory using high salt concentration as a negative unconditioned stimulus. These findings describe for the first time an involvement of 5-HT signaling in learning and memory in Drosophila larvae. In the longer run these results may uncover developmental, 5-HT dependent principles related to reinforcement processing possibly shared with adult Drosophila and other insects.

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Section: Discussionmentioning

confidence: 99%

Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae

et al. 2017

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“…The known insect biogenic amines are dopamine, tyramine, octopamine, serotonin, acetylcholine, and histamine. There probably exists no adrenaline or noradrenaline in insects (Blenau and Baumann, 2001;Blenau, 2005;Roeder, 2005). In inverte-brates, histamine seems to act exclusively on histamine-gated chloride channels (Roeder, 2003), which are not GPCRs and, therefore, will not be addressed in this paper.…”

Section: Biogenic Amine Receptorsmentioning

confidence: 99%

A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera

Hauser

Cazzamali

Williamson

et al. 2006

Progress in Neurobiology

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G protein-coupled receptor (GPCR) genes are large gene families in every animal, sometimes making up to 1-2% of the animal's genome. Of all insect GPCRs, the neurohormone (neuropeptide, protein hormone, biogenic amine) GPCRs are especially important, because they, together with their ligands, occupy a high hierarchic position in the physiology of insects and steer crucial processes such as development, reproduction, and behavior. In this paper, we give a review of our current knowledge on Drosophila melanogaster GPCRs and use this information to annotate the neurohormone GPCR genes present in the recently sequenced genome from the honey bee Apis mellifera. We found 35 neuropeptide receptor genes in the honey bee (44 in Drosophila) and two genes, coding for leucine-rich repeats-containing protein hormone GPCRs (4 in Drosophila). In addition, the honey bee has 19 biogenic amine receptor genes (21 in Drosophila). The larger numbers of neurohormone receptors in Drosophila are probably due to gene duplications that occurred during recent evolution of the fly. Our analyses also yielded the likely ligands for 40 of the 56 honey bee neurohormone GPCRs identified in this study. In addition, we made some interesting observations on neurohormone GPCR evolution and the evolution and co-evolution of their ligands. For neuropeptide and protein hormone GPCRs, there appears to be a general co-evolution between receptors and their ligands. This is in contrast to biogenic amine GPCRs, where evolutionarily unrelated GPCRs often bind to the same biogenic amine, suggesting frequent ligand exchanges ("ligand hops") during GPCR evolution.

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“…Biogenic amines, such as dopamine, serotonin, octopamine, tyramine and acetylcholine, are neurotransmitters and neurohormones that regulate a variety of behavioral and physiological processes, including locomotion, emotions, circadian rhythms, cardiovascular control, learning and memory (Blenau 2005 ;Blenau and Baumann 2001 ) . All biogenic amine GPCRs belong to Rhodopsin-like GPCR family.…”

Section: Biogenic Amine Gpcrsmentioning

confidence: 99%