Preface

Li, Songjun; Ge, Yi; Piletsky, Sergey A.; Lunec, Joseph

doi:10.1016/b978-0-444-56331-6.05001-5

Cited by 11 publications

(17 citation statements)

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“… HPLC on MIP columns [39,[44][45][46]  Solid phase extraction (SPE or MISPE) [47,48]  Membrane separations [49][50][51]  Sensors [52][53][54]  Binding assays [55][56][57]  Selective removal of low concentration contaminants in industrial or environmental technologies [5,8,9] In all of these applications selective separation or detection are needed. If selectivity between widely different compounds or groups of compounds is required, MIPs are suitable for any of the above tasks.…”

Section: Using the Log-log Isotherms To Understand And Design Practicmentioning

confidence: 99%

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

Dorkó

Tamás

Horvai

2017

Talanta

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A simple and efficient method is presented for assessing molecularly imprinted polymers (MIP) and other sorbents from the point of view of practical applications. The adsorption isotherms of the compounds, which need to be separated or detected in an application, are constructed from a small number of measured points on a log-log chart and then are compared graphically. Despite its simplicity and robustness this method reveals the information needed for optimal selection between MIPs and alternative sorbents. The design of separation or detection methods with MIPs is also supported by the proposed graphical isotherm comparison. Many experimental isotherms are presented supporting the proposed method.

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Section: Using the Log-log Isotherms To Understand And Design Practicmentioning

confidence: 99%

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

Dorkó

Tamás

Horvai

2017

Talanta

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“…Thus, the resultant polymeric network “recognizes” and binds selectively to the template molecules. Most of the time, acrylate and methacrylic monomers are used for the preparation of molecularly imprinted polymers [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

“…However, many biologically relevant compounds, including many emerging environmental pollutants, do not have correspondingly specific biorecognition elements. Fortunately, biomimetic chemistries, such as molecular imprinting, allow for the design of nanostructured, artificial receptors, based on shape, size, and functional group selectivity, that have greater stability than most biological recognition elements and the potential for very high selectivity [ 35 , 36 ]. The molecular imprinting technique offers a promising alternative to the use of traditional biorecognition elements, and has been used extensively for the development of high selectivity optical biosensors [ 23 , 35 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

“…The molecular imprinting technique offers a promising alternative to the use of traditional biorecognition elements, and has been used extensively for the development of high selectivity optical biosensors [ 23 , 35 , 37 ]. In general, artificial receptors created via the molecular imprinting of a target molecule are stable at a wide range of temperatures and pH, are typically less costly to create than natural biorecognition elements and easier to process, can be produced for almost any compound, and are significantly more compatible with the typical inorganic surfaces that comprise most label-free optical sensor surfaces than traditional biorecognition elements [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

“…The first attempt of using Molecularly Imprinted Polymers (MIPs) as a recognition element for biosensors was made in 1992 [ 36 ]. Since that time, MIPs have become an important class of synthetic, nanostructured material whose ability to selectively adsorb and otherwise interact with a variety of compounds has seen use not only in sensing applications but also in chemical and biological separations [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Integrating Nanostructured Artificial Receptors with Whispering Gallery Mode Optical Microresonators via Inorganic Molecular Imprinting Techniques

et al. 2016

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The creation of label-free biosensors capable of accurately detecting trace contaminants, particularly small organic molecules, is of significant interest for applications in environmental monitoring. This is achieved by pairing a high-sensitivity signal transducer with a biorecognition element that imparts selectivity towards the compound of interest. However, many environmental pollutants do not have corresponding biorecognition elements. Fortunately, biomimetic chemistries, such as molecular imprinting, allow for the design of artificial receptors with very high selectivity for the target. Here, we perform a proof-of-concept study to show how artificial receptors may be created from inorganic silanes using the molecular imprinting technique and paired with high-sensitivity transducers without loss of device performance. Silica microsphere Whispering Gallery Mode optical microresonators are coated with a silica thin film templated by a small fluorescent dye, fluorescein isothiocyanate, which serves as our model target. Oxygen plasma degradation and solvent extraction of the template are compared. Extracted optical devices are interacted with the template molecule to confirm successful sorption of the template. Surface characterization is accomplished via fluorescence and optical microscopy, ellipsometry, optical profilometry, and contact angle measurements. The quality factors of the devices are measured to evaluate the impact of the coating on device sensitivity. The resulting devices show uniform surface coating with no microstructural damage with Q factors above 106. This is the first report demonstrating the integration of these devices with molecular imprinting techniques, and could lead to new routes to biosensor creation for environmental monitoring.

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Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis

Mojtaba Mousavi,

Alireza Hashemi,

Yari Kalashgrani

et al. 2023

ChemMedChem

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Exosomes are essential indicators of molecular mechanisms involved in interacting with cancer cells and the tumor environment. As nanostructures based on lipids and nucleic acids, exosomes provide a communication pathway for information transfer by transporting biomolecules from the target cell to other cells. Importantly, these extracellular vesicles are released into the bloodstream by the most invasive cells, i. e., cancer cells; in this way, they could be considered a promising specific biomarker for cancer diagnosis. In this matter, CRISPR‐Cas systems and microfluidic approaches could be considered practical tools for cancer diagnosis and understanding cancer biology. CRISPR‐Cas systems, as a genome editing approach, provide a way to inactivate or even remove a target gene from the cell without affecting intracellular mechanisms. These practical systems provide vital information about the factors involved in cancer development that could lead to more effective cancer treatment. Meanwhile, microfluidic approaches can also significantly benefit cancer research due to their proper sensitivity, high throughput, low material consumption, low cost, and advanced spatial and temporal control. Thereby, employing CRISPR‐Cas‐ and microfluidics‐based approaches toward exosome monitoring could be considered a valuable source of information for cancer therapy and diagnosis. This review assesses the recent progress in these promising diagnosis approaches toward accurate cancer therapy and in‐depth study of cancer cell behavior.

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Preface

Cited by 11 publications

References 0 publications

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

Integrating Nanostructured Artificial Receptors with Whispering Gallery Mode Optical Microresonators via Inorganic Molecular Imprinting Techniques

Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis

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