Preface

Aniszewski, Tadeusz

doi:10.1016/b978-044452736-3/50002-7

Cited by 50 publications

(64 citation statements)

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“…Indeed, the peptide ring that they contain has one or more of its hydrogen atoms replaced with various alkyl radicals, most of which contain oxygen. As a consequence, alkaloids are capable of interacting with a wide spectrum of molecules [ 10 , 15 ]. In fact, out of thousands of different alkaloids, about 17,000 molecules have displayed pronounced biological and pharmacological activities [ 16 ].…”

Section: Plant-derived Alkaloids: a Fountain Of Bioactivmentioning

confidence: 99%

Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms

et al. 2017

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Considered as the second deadliest disease globally, cancer has captured the attention of researchers who have been trying with perseverance to decode its hidden aspects, to find new prognosis methods, and to develop better and more effective treatments. Plants have continuously offered an excess of unique secondary metabolites with remarkable biological applications. Alkaloids, one of the most abundant metabolites, constitute a large conglomerate of basic heterocyclic nitrogen-containing natural compounds which are normally produced by plants as toxic substances. Out of the 27,000 different alkaloids, more than 17,000 have displayed diversified pharmacological properties including anticancer activities. These metabolites have been classified either according to their chemical structures or their taxonomic origin. None of the researched alkaloids have been classified according to their molecular mechanism of action against cancer. In fact, only a fraction of the tremendous number of anticancer alkaloids has been copiously mentioned in journals. Here, we aim to provide a summary of the literature on some of the promising anticancer alkaloids that have not been well discussed previously and to classify them according to their molecular mechanisms of action. This review will provide a better understanding of the anticancer mechanisms of these promising natural products that are a rich reservoir for drug discovery.

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Section: Plant-derived Alkaloids: a Fountain Of Bioactivmentioning

confidence: 99%

Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms

et al. 2017

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“…The first alkaloids for medicinal use were isolated at the beginning of 19th century, by Derosne (opium salt, narcotine) and Sertürner ( principium somniferum, morphine). The chemical identification of morphine was carried in 1923, by Robinson and Gulland [ 18 , 19 ]. So far, there are more than 20000 alkaloids identified and a number of them have been placed an important role in clinical practice [ 20 ].…”

Section: Alkaloidsmentioning

confidence: 99%

“… Main alkaloids groups: True Alkaloids (a), Protolakaloids (b) and Pseudoalkaloids (c), precursors, and skeleton structures. Adapted from Aniszewski, 2007 [ 18 ]. Chemical structures were getting in PubChem database.…”

Section: Figurementioning

confidence: 99%

Recent Trends in Pharmacological Activity of Alkaloids in Animal Colitis: Potential Use for Inflammatory Bowel Disease

Almeida

de-Faria

Dunder

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Inflammatory bowel disease (IBD) is a chronic and disrupted inflammation of the gastrointestinal tract. IBD have two main conditions, Crohn's disease and ulcerative colitis, and have been extensively investigated in recent years. Antibiotics derived from salicylates, steroids, immunosuppressors, and anti-TNF therapy are part of the therapeutic arsenal for IBD. However, very often patients stop responding to treatments over the time. In this context, searching for alternative agents is crucial for IBD clinical management. Natural products derived from medicinal plants are an interesting therapeutic alternative, since several studies have proven effective treatments in animal models of intestinal inflammation. Several naturally occurring compounds are potent antioxidants, both as free radical scavengers and as modulators of antioxidant enzymes expression and activity. A number of natural compounds have also been proved to inhibit the release of proinflammatory cytokines, decreasing the activation of nuclear factor κB (NF-κB), which is important to the inflammatory response in IBD. The alkaloids are substances of a very diverse class of plant secondary metabolites; an extensive list of biological activities has been attributed to alkaloids, such as being anticholinergic, antitumor, diuretic, antiviral, antihypertensive, antiulcer, analgesic, and anti-inflammatory. In the present work, studies on the pharmacological activity of alkaloids in experimental models of IBD were reviewed.

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“…The alkaloids are a structurally diverse group of nitrogen-containing secondary metabolites with a relatively wide distribution in nature and a broad range of biological activities. 1 While the original definition of the term ‘alkaloid’, introduced by the German pharmacist Carl F. W. Meissner in 1819, 2 covers only plant-derived substances with alkaline character, modern conceptions are usually much broader. For instance, S. William Pelletier proposed a very simple definition in 1983, saying that “ An alkaloid is a cyclic organic compound containing nitrogen in a negative oxidation state which is of limited distribution among living organisms ” .…”

Section: Introductionmentioning

confidence: 99%