Preemptive analgesia in third molar impaction surgery

Shah, Rakesh; Mahajan, Amit; Shah, Nehal; Dadhania, Ashish P

doi:10.4103/0975-5950.111368

Cited by 15 publications

(7 citation statements)

References 15 publications

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“…Preemptive analgesia may decrease post-operative pain in the clinic. In previous clinical studies, preemptive administration of an analgesic agent has been shown to improve postoperative pain control in case of laparoscopic radical prostatectomy [ 28 ], thoracotomy [ 29 ], and third molar extraction [ 30 31 ]. Additionally, preemptive application of 1% lidocaine for 10 minutes prior to L4 and L5 bilateral dorsal rhizotomy significantly attenuates hindlimb mechanical allodynia in patients with failed back surgery syndrome [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Yoon

Son

Kim

et al. 2018

Korean J Physiol Pharmacol

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The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male Sprague-Dawley rats using chronic constriction injury of the infraorbital nerve (CCI-ION) and perineural application of 2% QX-314 to the infraorbital nerve. CCI-ION produced severe mechanical allodynia, which was maintained until postoperative day (POD) 30. An immediate single application of 2% QX-314 to the infraorbital nerve following CCI-ION significantly reduced neuropathic mechanical allodynia. Immediate double application of QX-314 produced a greater attenuation of mechanical allodynia than a single application of QX-314. Immediate double application of 2% QX-314 reduced the CCI-ION-induced upregulation of GFAP and p-p38 expression in the trigeminal ganglion. The upregulated p-p38 expression was co-localized with NeuN, a neuronal cell marker. We also investigated the role of voltage-gated sodium channels (Navs) in the antinociception produced by preemptive application of QX-314 through analysis of the changes in Nav expression in the trigeminal ganglion following CCI-ION. Preemptive application of QX-314 significantly reduced the upregulation of Nav1.3, 1.7, and 1.9 produced by CCI-ION. These results suggest that long-lasting blockade of the transmission of pain signaling inhibits the development of neuropathic pain through the regulation of Nav isoform expression in the trigeminal ganglion. Importantly, these results provide a potential preemptive therapeutic strategy for the treatment of neuropathic pain after nerve injury.

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Section: Discussionmentioning

confidence: 99%

Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Yoon

Son

Kim

et al. 2018

Korean J Physiol Pharmacol

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“…In the study by Bridgman et al diclofenac sodium did not demonstrate any significant pre-emptive analgesic effects ( 14 ). On the contrary Shah et al compared the analgesic effect of diclofenac sodium before and after third impacted molar surgery and suggested that preemptive medication provides better pain control ( 15 ). The findings in our study also support the notion to administer drugs preoperatively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effect of Naproxen, Etodolac and Diclofenac on postoperative sequelsfollowing third molar surgery: A randomised, double-blind, crossover study

Akbulut¹,

Üstüner²,

Atakan³

et al. 2014

Med Oral

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Objectives: To compare the three non-steroidal anti-inflammatory agents (NSAIDs) diclofenac potassium, etodolac and naproxen sodium in relation to pain, swelling and trismus following impacted third molar surgery. Study Design: The study was a randomized and a double-blinded study which included 42 healthy young individuals with impacted third molars and bone retention. Patients were randomly assigned to 3 groups (n: 14) to which diclofenac potassium, naproxen sodium and etodolac were administered orally an hour before the operation. Impacted third molars were surgically extracted with local anaesthesia. Visual analog scales (VAS) were used to assess the pain in the 6th, 12th hours and on the 1st, 2nd, 3rd, 5th, and 7th days postoperatively. Swelling was evaluated using ultrasound (US) and mouth opening (trismus) was measured with a composing stick pre and post operatively on the 2nd and 7th days respectively. Results: Regarding pain alleviation, diclofenac potassium was better than naproxen sodium and naproxen sodium was better than etodolac but these differences were not statistically significant. US measurements showed that the swelling on postoperative 2nd day was significantly lowest with diclofenac potassium as compared to others (p= 0.027) while naproxen sodium and etodolac acted similarly (p=0.747). No difference was noted regarding trismus in any of the groups. Conclusions: NSAIDs (diclofenac, naproxen and etodolac) are somehow similarly effective for controlling pain and trismus following extraction of mandibular third molars but diclofenac potassium surpasses others in reduction of swelling. Key words:Diclofenac potassium, naproxen sodium, etodolac, impacted third molar surgery, pain, swelling, trismus.

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“…However, in certain pathologic skeletal disorders, such as inflammatory bone loss, both processes do not occur consecutively [ 15 ]. Osteocytes also play a key role in the formation and remodeling of bone [ 16 ]. They are mechano-transducer cells and crucial determinants of bone quality [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Osteocytes also play a key role in the formation and remodeling of bone [ 16 ]. They are mechano-transducer cells and crucial determinants of bone quality [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Doped Electrospinned Material-Guides High Efficiency Regional Bone Regeneration

et al. 2023

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The main target of bone tissue engineering is to design biomaterials that support bone regeneration and vascularization. Nanostructured membranes of (MMA)1-co-(HEMA)1/(MA)3-co-(HEA)2 loaded with 5% wt of SiO2-nanoparticles (Si-M) were doped with zinc (Zn-Si-M) or doxycycline (Dox-Si-M). Critical bone defects were effectuated on six New Zealand-bred rabbit skulls and then they were covered with the membranes. After six weeks, a histological analysis (toluidine blue technique) was employed to determine bone cell population as osteoblasts, osteoclasts, osteocytes, M1 and M2 macrophages and vasculature. Membranes covering the bone defect determined a higher count of bone cells and blood vessels than in the sham group at the top regions of the defect. Pro-inflammatory M1 appeared in a higher number in the top regions than in the bottom regions, when Si-M and Dox-Si-M were used. Samples treated with Dox-Si-M showed a higher amount of anti-inflammatory and pro-regenerative M2 macrophages. The M1/M2 ratio obtained its lowest value in the absence of membranes. On the top regions, osteoblasts were more abundant when using Si-M and Zn-Si-M. Osteoclasts were equally distributed at the central and lateral regions. The sham group and samples treated with Zn-Si-M attained a higher number of osteocytes at the top regions. A preferential osteoconductive, osteoinductive and angiogenic clinical environment was created in the vicinity of the membrane placed on critical bone defects.

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Preemptive analgesia in third molar impaction surgery

Cited by 15 publications

References 15 publications

Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Comparison of the effect of Naproxen, Etodolac and Diclofenac on postoperative sequelsfollowing third molar surgery: A randomised, double-blind, crossover study

Doped Electrospinned Material-Guides High Efficiency Regional Bone Regeneration

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