Preeclampsia predicts higher incidence of bronchopulmonary dysplasia

Abstract

We conclude that, when controlling for gestational age, maternal PE results in higher incidence of only BPD among preterm Portuguese infants.

The effects of maternal preeclampsia on inflammatory cytokines and clinical outcomes in premature infants

“…In the literature, there are different studies reporting that birth weight and Apgar scores are lower in babies of preeclamptic mothers while thrombocytopenia, neutropenia, SGA, ROP, BPD and NEK ratios are higher. 13,[16][17][18][19] It is also reported that the babies of preeclamptic mothers stay longer in the hospital. 17 In our study, Apgar scores and birth weights of the babies of preeclamptic mothers were found to be significantly lower.…”

“…Preeclampsia continues to be one of the important causes of perinatal mortality and morbidity. 16 Maternal preeclampsia is reported to be associated with morbidity especially in premature infants. 16 According to our knowledge, for the first time in the literature, the levels of IL-6, IL-8, IL-10 and TNF-α in the cord blood of premature infants born at ≤32 weeks of gestational age from mothers with preeclampsia and normotensive mothers were compared.…”

“…16 Maternal preeclampsia is reported to be associated with morbidity especially in premature infants. 16 According to our knowledge, for the first time in the literature, the levels of IL-6, IL-8, IL-10 and TNF-α in the cord blood of premature infants born at ≤32 weeks of gestational age from mothers with preeclampsia and normotensive mothers were compared. No significant difference was found between the cytokine levels of babies in both groups.…”

“…In preeclampsia, inflammatory cytokines are released with a decrease in uteroplacental blood flow and hypoxia. 16 These cytokines and endothelial cell dysfunction cause a systemic inflammatory response. 16 All these processes can cause harmful effects on fetal and neonatal outcomes.…”

“…16 These cytokines and endothelial cell dysfunction cause a systemic inflammatory response. 16 All these processes can cause harmful effects on fetal and neonatal outcomes. 16 Although the cause of preeclampsia is not fully understood, the immune and vascular events play a role at the pathogenesis.…”