Preeclampsia is associated with an increased pro-inflammatory profile in newborns

Guillemette, Laetitia; Lacroix, Marilyn; Allard, Catherine; Patenaude, Johane; Battista, Marie-Claude; Doyon, Myriam; Moreau, Julie; Ménard, Julie; Ardilouze, Jean-Luc; Perron, Patrice; Côté, Anne‐Marie; Hivert, Marie‐France

doi:10.1016/j.jri.2015.09.003

Cited by 28 publications

(19 citation statements)

References 13 publications

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“…As such, the higher urinary NGAL levels observed in infants with MH seem to indicate that hypertensive disorders of pregnancy might trigger a pro-inflammatory status not only in the mother, but also in the offspring. In support of this hypothesis, elevated pro-inflammatory molecules in the cord blood of neonates born by hypertensive mothers compared to normotensive ones have been previously reported (36).…”

Section: Clinical Characteristics N=32supporting

confidence: 54%

Biomarkers of Kidney Injury in Very-low-birth-weight Preterm Infants: Influence of Maternal and Neonatal Factors

Capelli

Vitali

Zappulo

et al. 2020

In Vivo

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Background/Aim: Acute kidney injury is an important cause of mortality in very-low-birth-weight (VLBW) preterm infants. As in the general population, the detection of renal damage cannot rely on the measurement of serum creatinine, since it has been demonstrated to be a weak predictor and a delayed indicator of kidney function deterioration. However, several candidate biomarkers have failed to prove sufficient specificity and sensitivity for a routine clinical use because of the poor awareness of their biological role. This study was aimed to investigate the impact of different maternal and neonatal conditions on several renal biomarkers in VLBW preterm infants during the first week of life. Patients and Methods: Preterm infants<32 weeks' gestation and <1500g were enrolled. We measured urinary biomarkers kidney injury molecule 1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, epidermal growth factor (EGF) and osteopontin (OPN) on the 1 st , 3 rd , and 7 th day after birth. Results: Thirty-tree infants were included. The multivariate analysis showed a significant association between gestational age, the presence of patent ductus arteriosus, antenatal maternal hypertension and the levels of urinary biomarkers. Conclusion: There is a possible relation between early biomarkers of renal injury and antenatal, perinatal and post-natal characteristics in VLBW preterm infants during the first week of life. Preterm birth is burdened by high rates of perinatal morbidity and mortality worldwide (1). With an estimated incidence of 12-18%, acute kidney injury (AKI) is among the main causes of mortality in the preterm population, and represents an independent predictor of mortality even after adjustment for confounding variables, namely comorbidities, interventions and demographic characteristics (2, 3). Preterm birth is also associated with an increased risk of cardiovascular and chronic kidney disease in adulthood; this poses important challenges for the clinicians to detect as soon as possible developmental and functional abnormalities that could affect lifetime (4, 5). In humans and experimental animals, however, measurable changes in serum creatinine and glomerular filtration rates can be evident only after a remarkable reduction in kidney function (less than 50-80% of normal values), being thus insensitive to detect subclinical renal damage. Moreover, serum creatinine levels can be influenced by several factors, such as gender, age, hydration state, muscle mass, ongoing medications and endogenous metabolites (e.g., bilirubin) (3, 6). In the neonatal population, AKI definitions based on serum creatinine are susceptible to specific additional limitations: in the first days of life, serum creatinine may reflect the maternal kidney function (7, 8) and it is not able to distinguish pre-renal injuries, which are often reversible and transient, from intrinsic renal injuries (9). Moreover, serum creatinine does not provide specific information on the type of kidney insult (e.g., toxic, infectious, ischemic...

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Section: Clinical Characteristics N=32supporting

confidence: 54%

Biomarkers of Kidney Injury in Very-low-birth-weight Preterm Infants: Influence of Maternal and Neonatal Factors

Capelli

Vitali

Zappulo

et al. 2020

In Vivo

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“…TNFα, which is inducible by IL-17, is elevated in peripheral blood of PE patients; however, it does not show significant alterations in serum samples taken in the first two trimesters. Another study proposed inflammation of the maternal vasculature, indicated by elevated levels of TNFα and ICAM-1 [100,101]. TNFα induces the expression of the intercellular adhesion molecule ICAM-1 [102] thereby mediating neutrophil adhesion to endothelial cells which has been observed during PE [101,103].…”

Section: Immunological Backgroundmentioning

confidence: 99%

Immunology of hepatic diseases during pregnancy

2016

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The mother's immune system has to adapt to pregnancy accepting the semi-allograft fetus and preventing harmful effects to the developing child. Aberrations in feto-maternal immune adaptation may result in disease of the mother, such as liver injury. Five pregnancy-associated liver disorders have been described so far, however, little is known concerning immune alterations promoting the respective disease. These liver disorders are pre-eclampsia, hemolysis, elevated liver enzymes, low platelet count (HELLP), acute fatty liver, hyperemesis gravidarum, and intrahepatic cholestasis of pregnancy. On the other hand, pre-existing autoimmune liver injury of the mother can be affected by pregnancy. This review intends to summarize current knowledge linking feto-maternal immunology and liver inflammation with a special emphasis on novel potential biomarkers.

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“…As delivery of the placenta is the only effective treatment for PE, babies born to women with PE often suffer from intrauterine growth restriction and preterm birth along with some of the associated neonatal comorbidities (i.e., respiratory distress syndrome, intraventricular hemorrhage) and increased fetal pro-inflammatory profiles [67•]. In addition to this, these children are more susceptible to neurodevelopmental and behavioral problems as well as cardiovascular diseases as they age [68•].…”

Section: Preeclampsia Affects Not Only the Mother But Also The Offspringmentioning

confidence: 99%

Pathophysiology and Current Clinical Management of Preeclampsia

et al. 2017

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Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy. This disease is a major contributor to preterm and low birth weight babies. The early delivery of the baby, which becomes necessary for maintaining maternal well-being, makes pre-eclampsia the leading cause for preterm labor and infant mortality and morbidity. Currently, there is no cure for this pregnancy disorder. The current clinical management of PE is hydralazine with labetalol and magnesium sulfate to slow disease progression and prevent maternal seizure, and hopefully prolong the pregnancy. This review will highlight factors implicated in the pathophysiology of preeclampsia and current treatments for the management of this disease.

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Preeclampsia is associated with an increased pro-inflammatory profile in newborns

Cited by 28 publications

References 13 publications

Biomarkers of Kidney Injury in Very-low-birth-weight Preterm Infants: Influence of Maternal and Neonatal Factors

Biomarkers of Kidney Injury in Very-low-birth-weight Preterm Infants: Influence of Maternal and Neonatal Factors

Immunology of hepatic diseases during pregnancy

Pathophysiology and Current Clinical Management of Preeclampsia

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