Preeclampsia is associated with a decrease in plasma coenzyme Q10 levels

Effects of lifestyle factors on urinary oxidative stress and serum antioxidant markers in pregnant Japanese women: A cohort study

“…Therefore, biopyrrin was adopted as a marker for oxidative stress because it is a predictor of optimal lifestyle during pregnancy. Furthermore, the antioxidant CoQ10 was used to clarify the relationship between oxidative stress and pregnancy complications in previous studies (1,3). In addition, CoQ10 has a strong antioxidant effect on the human body; hence, it was considered as a marker for oxidative stress.…”

“…Blood pressure ≥ 140/90mmHg 3) Urinary Protein ≥ 1+ Data are median (range; minimum -maximum) or n (%).…”

“…Various complications of pregnancy, such as preeclampsia (PE), pregnancy-induced hypertension (PIH), and gestational diabetes mellitus (GDM), are associated with oxidative stress (1)(2)(3)(4)(5). Thus, clinical and experimental evidence indicates that oxidative stress is important in the aetiology of PE, PIH, and GDM.…”

“…Thus, clinical and experimental evidence indicates that oxidative stress is important in the aetiology of PE, PIH, and GDM. The levels of oxidative stress markers, such as oxidised lowdensity lipoprotein (LDL) and malondialdehyde, are higher (6) and those of antioxidants, such as coenzyme Q10 (CoQ10), α-tocopherol, and vitamin C, are lower (1,3,7) in women experiencing PE, PIH, or GDM, compared with healthy pregnant women. Accumulation of Reactive oxygen species (ROS) in cells may cause DNA damage (8), which may lead to pregnancy-related complications.…”

Role of Heme Oxygenase, Leptin, Coenzyme Q10 and Trace Elements in Pre-eclamptic Women

“…Increase of CoQ 10 during normal pregnancy most likely depends on the increase in LDL, which is the main carrier of CoQ 10 in plasma [26] and the increase in cholesterol level which is the biosynthetic pathway for CoQ 10 [27].Decrease of CoQ 10 during pre-eclampsia is due to direct reaction with free NO in reversible manner resulting in inhibition of mitochondrial complex I activity [26]. Gürkan and Bozdag-Dündar [28] stated that CoQ 10 reduces blood viscosity and improves blood flow thus reducing the systolic and diastolic pressure.…”