Preeclampsia-induced alterations in brain and liver gene expression and DNA methylation patterns in fetal mice

Hofsink, Naomi; Dijkstra, Dorieke J.; Stojanovska, Violeta; Scherjon, Sicco A.; Plösch, Torsten

doi:10.1017/s2040174422000344

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Based on these findings, it is speculated that DNA methylation may play a role in mediating the increased risk of vascular disease later in life associated with PIH. Due to ethical constraints on human research, experimental animals were used to investigate the effects of maternal PIH on gene DNA methylation in multiple generations of offspring and its role in the occurrence of offspring diseases [ 197 , 198 ]. For instance, Guan et al [ 197 ] found that DNA hypomethylation of the G signaling gene in F1 sperm and F2 thoracic aorta, along with hyperactivation of downstream PI3K-Akt signaling, suggests that DNA methylation plays a crucial role in the development of hypertension in PIH offspring.…”

Section: Dna Methylation Changes In Pih Neonates and Childrenmentioning

confidence: 99%

DNA methylation landscape in pregnancy-induced hypertension: progress and challenges

Deng,

Lei,

Qiu

et al. 2024

Reprod Biol Endocrinol

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Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the health of both the mother and the fetus. Emerging evidence suggests that epigenetic modifications, particularly DNA methylation, may play a role in initiating the earliest pathophysiology of PIH. This article describes the relationship between DNA methylation and placental trophoblast function, genes associated with the placental microenvironment, the placental vascular system, and maternal blood and vascular function, abnormalities of umbilical cord blood and vascular function in the onset and progression of PIH, as well as changes in DNA methylation in the progeny of PIH, in terms of maternal, fetal, and offspring. We also explore the latest research on DNA methylation-based early detection, diagnosis and potential therapeutic strategies for PIH. This will enable the field of DNA methylation research to continue to enhance our understanding of the epigenetic regulation of PIH genes and identify potential therapeutic targets.

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Section: Dna Methylation Changes In Pih Neonates and Childrenmentioning

confidence: 99%

DNA methylation landscape in pregnancy-induced hypertension: progress and challenges

Deng,

Lei,

Qiu

et al. 2024

Reprod Biol Endocrinol

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“…Some animal studies have demonstrated a higher predisposition to cerebral complications in male than female offspring of preeclampsia. 61,62 A properly designed study to specifically analyze potential sexual dimorphism in the brain angiogenesis formation and function in offspring from preeclampsia is underway in our laboratory.…”

Section: Discussionmentioning

confidence: 99%

Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome

Troncoso,

Sandoval,

Ibañez

et al. 2023

Hypertension

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BACKGROUND: Children from pregnancies affected by preeclampsia have an increased risk of cognitive and behavioral alterations via unknown pathophysiology. We tested the hypothesis that preeclampsia generated reduced brain cortex angiogenesis in the offspring. METHODS: The preeclampsia-like syndrome (PELS) mouse model was generated by administering the NO inhibitor NG-nitroarginine methyl ester hydrochloride. Confirmatory experiments were done using 2 additional PELS models. While in vitro analysis used mice and human brain endothelial cells exposed to serum of postnatal day 5 pups or umbilical plasma from preeclamptic pregnancies, respectively. RESULTS: We report significant reduction in the area occupied by blood vessels in the motor and somatosensory brain cortex of offspring (postnatal day 5) from PELS compared with uncomplicated control offspring. These data were confirmed using 2 additional PELS models. Furthermore, circulating levels of critical proangiogenic factors, VEGF (vascular endothelial growth factor), and PlGF (placental growth factor) were lower in postnatal day 5 PELS. Also we found lower VEGF receptor 2 (KDR [kinase insert domain-containing receptor]) levels in mice and human endothelial cells exposed to the serum of postnatal day 5 PELS or fetal plasma of preeclamptic pregnancies, respectively. These changes were associated with lower in vitro angiogenic capacity, diminished cell migration, larger F-actin filaments, lower number of filopodia, and lower protein levels of F-actin polymerization regulators in brain endothelial cells exposed to serum or fetal plasma of offspring from preeclampsia. CONCLUSIONS: Offspring from preeclampsia exhibited diminished brain cortex angiogenesis, associated with lower circulating VEGF/PlGF/KDR protein levels, impaired brain endothelial migration, and dysfunctional assembly of F-actin filaments. These alterations may predispose to structural and functional alterations in long-term brain development.

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Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation

Chen,

Luo,

Deng

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Preeclampsia-induced alterations in brain and liver gene expression and DNA methylation patterns in fetal mice

Cited by 3 publications

References 23 publications

DNA methylation landscape in pregnancy-induced hypertension: progress and challenges

DNA methylation landscape in pregnancy-induced hypertension: progress and challenges

Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome

Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation

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